Exatecan Intermediate 6

Cat. No.: HY-44369 Purity: 98.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

For research use only. We do not sell to patients.

Exatecan Intermediate 6 Chemical Structure

CAS No. : 143655-58-7

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
250 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
1 g	USD 60	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Camptothecins

Molecular Weight

235.25

Formula

C₁₃H₁₄FNO₂

CAS No.

143655-58-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(NC(C=C(F)C(C)=C1CCC2)=C1C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (106.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2508 mL	21.2540 mL	42.5080 mL
5 mM	0.8502 mL	4.2508 mL	8.5016 mL
10 mM	0.4251 mL	2.1254 mL	4.2508 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.92%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (251 KB) HNMR (218 KB) RP-HPLC (215 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998 A. 2020-07-31.

[2]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2508 mL	21.2540 mL	42.5080 mL	106.2699 mL
	5 mM	0.8502 mL	4.2508 mL	8.5016 mL	21.2540 mL
	10 mM	0.4251 mL	2.1254 mL	4.2508 mL	10.6270 mL
	15 mM	0.2834 mL	1.4169 mL	2.8339 mL	7.0847 mL
	20 mM	0.2125 mL	1.0627 mL	2.1254 mL	5.3135 mL
	25 mM	0.1700 mL	0.8502 mL	1.7003 mL	4.2508 mL
	30 mM	0.1417 mL	0.7085 mL	1.4169 mL	3.5423 mL
	40 mM	0.1063 mL	0.5313 mL	1.0627 mL	2.6567 mL
	50 mM	0.0850 mL	0.4251 mL	0.8502 mL	2.1254 mL
	60 mM	0.0708 mL	0.3542 mL	0.7085 mL	1.7712 mL
	80 mM	0.0531 mL	0.2657 mL	0.5313 mL	1.3284 mL
	100 mM	0.0425 mL	0.2125 mL	0.4251 mL	1.0627 mL