1. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  2. ADC Cytotoxin Topoisomerase
  3. Exatecan Intermediate 6

Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

For research use only. We do not sell to patients.

Exatecan Intermediate 6 Chemical Structure

Exatecan Intermediate 6 Chemical Structure

CAS No. : 143655-58-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 33 In-stock
Solution
10 mM * 1 mL in DMSO USD 33 In-stock
Solid
250 mg USD 30 In-stock
1 g USD 60 In-stock
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Description

Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

IC50 & Target

Camptothecins

 

Molecular Weight

235.25

Formula

C13H14FNO2

CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

CC(NC(C=C(F)C(C)=C1CCC2)=C1C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (106.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2508 mL 21.2540 mL 42.5080 mL
5 mM 0.8502 mL 4.2508 mL 8.5016 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.92%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2508 mL 21.2540 mL 42.5080 mL 106.2699 mL
5 mM 0.8502 mL 4.2508 mL 8.5016 mL 21.2540 mL
10 mM 0.4251 mL 2.1254 mL 4.2508 mL 10.6270 mL
15 mM 0.2834 mL 1.4169 mL 2.8339 mL 7.0847 mL
20 mM 0.2125 mL 1.0627 mL 2.1254 mL 5.3135 mL
25 mM 0.1700 mL 0.8502 mL 1.7003 mL 4.2508 mL
30 mM 0.1417 mL 0.7085 mL 1.4169 mL 3.5423 mL
40 mM 0.1063 mL 0.5313 mL 1.0627 mL 2.6567 mL
50 mM 0.0850 mL 0.4251 mL 0.8502 mL 2.1254 mL
60 mM 0.0708 mL 0.3542 mL 0.7085 mL 1.7712 mL
80 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.3284 mL
100 mM 0.0425 mL 0.2125 mL 0.4251 mL 1.0627 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Exatecan Intermediate 6
Cat. No.:
HY-44369
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