1. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  2. ADC Cytotoxin Topoisomerase
  3. Exatecan intermediate 9

Exatecan intermediate 9 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).

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Exatecan intermediate 9 Chemical Structure

Exatecan intermediate 9 Chemical Structure

CAS No. : 2290562-59-1

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Description

Exatecan intermediate 9 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].

IC50 & Target

Camptothecins

 

Molecular Weight

477.48

Formula

C26H24FN3O5

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OC1)[C@](O)(CC)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C(C(NC(C)=O)CC6)=C4C3)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.80%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Exatecan intermediate 9
Cat. No.:
HY-43565
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