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Results for "

Protein cross-linker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Drug-Linker Conjugates for ADC (1) E3 Ligase Ligand-Linker Conjugates (1) Antibiotic (3) Apoptosis (2) Bacterial (3) Biochemical Assay Reagents (18) DNA Alkylator/Crosslinker (2) Endogenous Metabolite (2) Fluorescent Dye (2)
By Research Areas:	Cancer (10) Infection (4) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (2)
Click Chemistry:	PROTAC Synthesis (1) Azide (5) Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: ADC Linker Target Protein Ligand-Linker Conjugates PROTAC-Linker Conjugates for PAC Drug-Linker Conjugates for ADC E3 Ligase Ligand-Linker Conjugates

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157414

Azide-A-DSBSO crosslinker	Others	Others
Azide-A-DSBSO crosslinker is a mass spectrometry (MS)-cleavable, membrane-permeable, homobifunctional, azide-labeled, acid-cleavable cross-linked peptide. Azide-A-DSBSO crosslinker enables the study of protein-protein interactions via cross-linking mass spectrometry (XL-MS) .

HY-W041994

GMBS	Biochemical Assay Reagents	Cancer
GMBS is a heterobifunctional cross-linker. GMBS can be used in chemical cross-linking of proteins coupled with mass spectrometry (CXMS) to study protein folding and to map the interfaces between interacting proteins .

HY-123740

Disuccinimidyl sulfoxide DSSO	Biochemical Assay Reagents	Others
Disuccinimidyl sulfoxide (DSSO) is a mass spectrometry (MS)-cleavable cross-linker that is applicable for model peptides and proteins and a multisubunit protein complex. Disuccinimidyl sulfoxide contains two symmetric collision-induced dissociation (CID)-cleavable sites for identification of DSSO-cross-linked peptides based their distinct fragmentation patterns .

HY-W010756

FMOC-AM	Others	Others
FMOC-AM is a protein cross-linking agent.

HY-W074785

Carboxyl diazirine alkyne	Biochemical Assay Reagents	Others
Carboxyl diazirine alkyne is a protein cross-linking compound .

HY-W017831

2-Maleimido acetic acid	Others	Others
2-Maleimido acetic acid is a protein cross-linking agent.

HY-W096122

DTSSP Crosslinker disodium	Others	Others
DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .

HY-137251

Sulfo-MBS sodium	Biochemical Assay Reagents	Others
Sulfo-MBS sodium is a heterobifunctional crosslinker with a maleimide group and an N-hydroxysuccinimide (NHS) ester group, which can react with cysteine residues and lysine residues on proteins. Sulfo-MBS sodium be used for protein cross-linking studies .

HY-W009034

Fmoc-Suberol	Others	Others
Fmoc-Suberol is a protein cross-linking agent.

HY-159008

NHSF	Biochemical Assay Reagents	Others
NHSF is a protein cross-linking agent .

HY-148140

Cross-linked dextran G 25 1 Publications Verification	Others	Others
Cross-linked dextran G 25 is a dextran chromatography medium. Cross-linked dextran G 25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins .

HY-W040113

6-(N-Boc)caproic acid NHS	Others	Others
6-(N-Boc)caproic acid NHS is a protein cross-linking agent.

HY-135066

Triallyl pentaerythritol Pentaerythritol triallyl ether	Others	Others
Triallyl pentaerythritol (PEATA), a crosslinker, decreases the protein rejection compared to membranes functionalized with MBAA or without any crosslinker .

HY-76214

Dibenzyl hydrazodicarboxylate Dibenzyl hydrazine-1,2-dicarboxylate	Others	Others
Dibenzyl hydrazodicarboxylate (Dibenzyl hydrazine-1,2-dicarboxylate) is a protein cross-linking agent.

HY-W013538

1,2-Bis(maleimido)ethane N,N'-Ethylenedimaleimide	Others	Others
1,2-Bis(maleimido)ethane (N,N'-Ethylenedimaleimide) is a protein cross-linking agent.

HY-W264744

3-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
3-Maleimidobenzoic acid is a protein crosslinker .

HY-W012166

N-Succinimidyl bromoacetate NHS-Bromoacetate	Biochemical Assay Reagents	Others
N-Succinimidyl bromoacetate is a heterobifunctional cross-linking reagent can be used to prepare peptide-protein immunogens .

HY-W008575

N-Fmoc-N-methoxy-3-aminopropionic acid	Others	Others
N-Fmoc-N-methoxy-3-aminopropionic acid, a Weinreb amide linker, is a protein cross-linking agent .

HY-W332335

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium	Biochemical Assay Reagents	Others
Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium is a protein crosslinker, and is a biotinylation reagentcan for labeling cell surface proteins .

HY-138560

Cross-linked dextran G 50 1 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-W104848

4-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers .

HY-W123005

Dimethyl pimelimidate dihydrochloride	Biochemical Assay Reagents	Others
Dimethyl pimelimidate dihydrochloride (DMP) is a protein crosslinker that can be used in chromatin immunoprecipitation experiments (ChIP) to enhance signal .

HY-42360

SMCC	ADC Linker	Cancer
SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses .

HY-148139

Cross-linked dextran G 75	Biochemical Assay Reagents	Others
Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da) .

HY-D0853

DiAzKs 1 Publications Verification H-L-Photo-lysine	Fluorescent Dye	Others
DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe .

HY-D0853A

DiAzKs hydrochloride 1 Publications Verification H-L-Photo-lysine hydrochloride	Fluorescent Dye	Others
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe .

HY-117080

Sulfo-EGS	Biochemical Assay Reagents	Others
Sulfo-EGS is a homobifunctional, amine-reactive chemical crosslinker. Sulfo-EGS is used to study protein-protein or protein-peptide interactions, which can determine the spatial proximity of amino acid residues in a protein complex, without relying on standards .

HY-129380

Fructosyl-lysine Fructoselysine	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-129380A

Fructosyl-lysine dihydrochloride Fructoselysine dihydrochloride	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-48999A

FSK hydrochloride	Others	Cancer
FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chain that can reach protein sites that are difficult to reach by covalent linkage. FSK hydrochloride is a modified nanomolecule that targets the epidermal growth factor receptor (EGFR), creating a covalent binding that results in irreversible binding. FSK hydrochloride captures unknown enzyme-substrate interactions in living cells through genetically encoded chemical cross-linking, targeting residues beyond Cys, and cross-linking at the binding periphery. FSK hydrochloride enables the construction of bioreactive SuFEx systems for creating covalent bonds in different proteins in vitro and in vivo .

HY-B0245

Busulfan Maximum Cited Publications 13 Publications Verification	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-141522

Cross-linked dextran G 100	Biochemical Assay Reagents	Others
Cross-linked dextran G 100 is a gel filtration medium that can be used for protein purification (Sphere protein separation range: 4K-150K Da; Polysaccharide separation range: 1K-100K Da) .

HY-E70393H

Human Factor XIIIa	Others	Others
Human Factor XIIIa is a transglutaminase, which catalyzes the cross-linking of proteins and stabilizes the blood clots. Human Factor XIIIa protects the clots from degradation by fibrinolytic enzymes, which is important for maintaining hemostasis and preventing excessive bleeding .

HY-W319374

2-(Methylsulfonyl)ethyl n-succinimidyl carbonate	Biochemical Assay Reagents	Others
2-(Methylsulfonyl)ethyl n-succinimidyl carbonate is a protein crosslinker. 2-(Methylsulfonyl)ethyl n-succinimidyl carbonate has amino protective function .

HY-W074006

Tris(2-cyanoethyl)phosphine	Biochemical Assay Reagents	Others
Tris(2-cyanoethyl)phosphine is a protein crosslinker. Tris(2-cyanoethyl)phosphine can be used to synthesis copper(I) complexes which shows antitumour activity .

HY-113033

Pentosidine	Others	Neurological Disease Metabolic Disease
Pentosidine is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-113033A

Pentosidine TFA	Others	Neurological Disease Metabolic Disease
Pentosidine TFA is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine TFA is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease .

HY-142740

Rha-PEG3-SMCC	Drug-Linker Conjugates for ADC	Cancer
Rha-PEG3-SMCC (compound 13) is a agent-linker conjugate for ADC with potent antitumor activity by using SMCC (a protein crosslinker), linked via the noncleavable ADC linker Rha-PEG3.

HY-157232

AC Antibody purification resin 2	Others	Others
AC Antibody purification resin 2 is based on spherical, highly cross-linked agarose beads with a narrow size distribution and high mechanical stability. Used for the separation and purification of complex antibodies such as monoclonal antibody, double antibody, multi-antibody and Fc fusion protein . Substrate: highly crosslinked agarose microspheres; Particle size: 65μm; Ligand: alkali-resistant recombinant Protein A; ADC purified resin.

HY-157235

AC Antibody affinity resin	Others	Inflammation/Immunology
AC Antibody affinity resin is AC commonly used packing. AC Antibody affinity resin has highly cross-linked agarose matrix with 85 μm of average particle size. AC Antibody affinity resin has alkali-resistant protein A derivative (E. coli) ligand. AC Antibody affinity resin can be used for antibody affinity chromatography .

HY-W043748

2,5-Dioxopyrrolidin-1-yl acrylate N-Succinimidyl acrylate	Biochemical Assay Reagents	Others
2,5-Dioxopyrrolidin-1-yl acrylate (N-Succinimidyl acrylate) is a protein crosslinker. 2,5-Dioxopyrrolidin-1-yl acrylate can react with a monoclonal anti-horseradish peroxidase IgG antibody (anti-HRP) to modify lysine residues .

HY-13588

Cefsulodin sodium SCE-129 sodium	Bacterial Antibiotic	Infection
Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM .

HY-13588B

Cefsulodin sodium hydrate SCE-129 sodium hydrate	Antibiotic Bacterial	Infection
Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM .

HY-150014

AMT-NHS	Others	Others
AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells .

HY-13588R

Cefsulodin sodium (Standard)	Bacterial Antibiotic	Infection
Cefsulodin (sodium) (Standard) is the analytical standard of Cefsulodin (sodium). This product is intended for research and analytical applications. Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM .

HY-W127719

Photobiotin acetate	Biochemical Assay Reagents	Others
Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151792

Pomalidomid-C6-PEG3-butyl-N3	E3 Ligase Ligand-Linker Conjugates	Metabolic Disease Inflammation/Immunology Cancer
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3	ADC Linker	Others
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-106024A

Alagebrium bromide ALT711 bromide	Others	Infection
Alagebrium bromide is a cross-link breaker. This study investigated the role of advanced glycation end products (AGEs) in mediating protein kinase C (PKC) isoform expression in diabetic nephropathy. In vitro, vascular smooth muscle cells cultured in high glucose (25-mmol/l) showed increased translocation and expression of PKC-α compared with cells cultured in low glucose (5-mmol/l). Coculture with ALT-711 more effectively attenuated the increased expression and translocation of PKC-α compared with aminoguanidine, an inhibitor of AGE formation. Streptozotocin-induced diabetic rats were randomized to no treatment, ALT-711 treatment, or aminoguanidine treatment. Diabetes induced an increase in PKC-α as well as -βI, -βII, and -ε isoforms. ALT-711 and aminoguanidine treatment, both of which attenuated renal AGE accumulation, abolished these increases in PKC expression. However, only ALT-711 reduced the translocation of phosphorylated PKC-α from the cytoplasm to the membrane. ALT-711 treatment attenuated the expression of vascular endothelial growth factor (VEGF) and extracellular matrix proteins (fibronectin and laminin) and was associated with a reduction in albuminuria. Aminoguanidine had no effect on VEGF expression, although a reduction in fibronectin and laminin was observed. These findings suggest that AGEs are important stimulators of PKC activation, particularly PKC-α, in patients with diabetic nephropathy, which can be directly inhibited by ALT-711.

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library

1,348 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,348 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-D0853

DiAzKs 1 Publications Verification H-L-Photo-lysine	Fluorescent Dyes/Probes
DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe .

HY-D0853A

DiAzKs hydrochloride 1 Publications Verification H-L-Photo-lysine hydrochloride	Fluorescent Dyes/Probes
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe .

Cat. No.	Product Name	Type

HY-W074785

Carboxyl diazirine alkyne	Biochemical Assay Reagents
Carboxyl diazirine alkyne is a protein cross-linking compound .

HY-138560

Cross-linked dextran G 50 1 Publications Verification	Filter Medium
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-148139

Cross-linked dextran G 75	Filter Medium
Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da) .

HY-141522

Cross-linked dextran G 100	Filter Medium
Cross-linked dextran G 100 is a gel filtration medium that can be used for protein purification (Sphere protein separation range: 4K-150K Da; Polysaccharide separation range: 1K-100K Da) .

HY-156045B

Cross-linked dextran G 150	Filter Medium
Cross-linked dextran G 150 is a hydrophilic gel that can be used as a gel filter filler (Particle size range: 40-120 μm; Sphere protein separation range: 5k-300k Da) .

HY-156045C

Cross-linked dextran G 200	Filter Medium
Cross-linked dextran G 200 is a hydrophilic gel that can be used as a gel filter filler (Particle size range: 40-120 μm; Sphere protein separation range: 5k-600k Da) .

HY-156045

Cross-linked dextran G 15	Filter Medium
Cross-linked dextran G 15 is a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: ＜1500 Da; Polysaccharide separation range: ＜1500 Da) .

HY-156045A

Cross-linked dextran G 10	Filter Medium
Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: ＜700 Da; Polysaccharide separation range: ＜700 Da) .

HY-W127719

Photobiotin acetate

Biochemical Assay Reagents

Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name

HY-K0213

Protein A Agarose 1 Publications Verification
MCE Protein A Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein A, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG, IgE, IgM.

HY-K0215

Protein L Agarose
MCE Protein L Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein L, effectively purifies mammalian monoclonal and polyclonal antibodies which have kappa light chain.

HY-K0211

Glutathione Agarose 2 Publications Verification
MCE Glutathione Agarose, a 4% highly cross-linked agarose reagent, enables high-yield, high-purity purification of GST-tagged proteins.

HY-K0214

Protein G Agarose 2 Publications Verification
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

HY-K0210

Ni-NTA His-Tag Purification Agarose Maximum Cited Publications 11 Publications Verification
MCE Ni-NTA His-Tag Purification Agarose, a 6% highly cross-linked agarose reagent, enables high-yield, high-purity purification of his-tagged proteins.

HY-K0219

High-Affinity Iodoacetyl Agarose
MCE High-Affinity Iodoacetyl Agarose, a 4% highly cross-linked agarose reagent coupled with a derivative of iodoacetic acid, is ideal for conjugating sulfhydryl-containing peptide or protein for subsequent affinity purification.

Cat. No.	Product Name	Target	Research Area

HY-P99306

Modotuximab DS 1024; Sym 004	Inhibitory Antibodies	Cancer
Modotuximab (Anti-Human EGFR Recombinant Antibody) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab contains a portion of Futuximab that binds to two independent, non-overlapping epitopes on EGFR. Modotuximab promotes cross-linking of EGFR on the cell surface and promotes EGFR cellular internalization and degradation. Modotuximab has antitumor activity in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-129380

Fructosyl-lysine Fructoselysine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-129380A

Fructosyl-lysine dihydrochloride Fructoselysine dihydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-P99306

Modotuximab DS 1024; Sym 004	Classification of Application Fields Disease Research Fields Cancer	Others
Modotuximab (Anti-Human EGFR Recombinant Antibody) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab contains a portion of Futuximab that binds to two independent, non-overlapping epitopes on EGFR. Modotuximab promotes cross-linking of EGFR on the cell surface and promotes EGFR cellular internalization and degradation. Modotuximab has antitumor activity in vivo .

HY-113033

Pentosidine	Structural Classification Natural Products Source classification Disease markers Endogenous metabolite	Others
Pentosidine is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

Cat. No.	Product Name		Classification

HY-W074785

Carboxyl diazirine alkyne		Alkynes
Carboxyl diazirine alkyne is a protein cross-linking compound .

HY-111434

UAA crosslinker 1		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111434A

UAA crosslinker 1 hydrochloride		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W127719

Photobiotin acetate		Azide
Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		PROTAC Synthesis Azide
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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