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  4. FSK hydrochloride

FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chain that can reach protein sites that are difficult to reach by covalent linkage. FSK hydrochloride is a modified nanomolecule that targets the epidermal growth factor receptor (EGFR), creating a covalent binding that results in irreversible binding. FSK hydrochloride captures unknown enzyme-substrate interactions in living cells through genetically encoded chemical cross-linking, targeting residues beyond Cys, and cross-linking at the binding periphery. FSK hydrochloride enables the construction of bioreactive SuFEx systems for creating covalent bonds in different proteins in vitro and in vivo.

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FSK hydrochloride Chemical Structure

FSK hydrochloride Chemical Structure

CAS No. : 3033987-42-4

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5 mg USD 120 In-stock
10 mg USD 195 In-stock
25 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chain that can reach protein sites that are difficult to reach by covalent linkage. FSK hydrochloride is a modified nanomolecule that targets the epidermal growth factor receptor (EGFR), creating a covalent binding that results in irreversible binding. FSK hydrochloride captures unknown enzyme-substrate interactions in living cells through genetically encoded chemical cross-linking, targeting residues beyond Cys, and cross-linking at the binding periphery. FSK hydrochloride enables the construction of bioreactive SuFEx systems for creating covalent bonds in different proteins in vitro and in vivo[1].

Molecular Weight

384.81

Formula

C13H18ClFN2O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCC[C@H](N)C(O)=O)C1=CC=C(OS(F)(=O)=O)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (162.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5987 mL 12.9934 mL 25.9869 mL
5 mM 0.5197 mL 2.5987 mL 5.1974 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5987 mL 12.9934 mL 25.9869 mL 64.9671 mL
5 mM 0.5197 mL 2.5987 mL 5.1974 mL 12.9934 mL
10 mM 0.2599 mL 1.2993 mL 2.5987 mL 6.4967 mL
15 mM 0.1732 mL 0.8662 mL 1.7325 mL 4.3311 mL
20 mM 0.1299 mL 0.6497 mL 1.2993 mL 3.2484 mL
25 mM 0.1039 mL 0.5197 mL 1.0395 mL 2.5987 mL
30 mM 0.0866 mL 0.4331 mL 0.8662 mL 2.1656 mL
40 mM 0.0650 mL 0.3248 mL 0.6497 mL 1.6242 mL
50 mM 0.0520 mL 0.2599 mL 0.5197 mL 1.2993 mL
60 mM 0.0433 mL 0.2166 mL 0.4331 mL 1.0828 mL
80 mM 0.0325 mL 0.1624 mL 0.3248 mL 0.8121 mL
100 mM 0.0260 mL 0.1299 mL 0.2599 mL 0.6497 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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FSK hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSK3033987-42-4OthersInhibitorinhibitorinhibit

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FSK hydrochloride
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