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ROS-IN-1

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

1

Fluorescent Dye

2

Peptides

8

Natural
Products

2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153591
    ROS-IN-1

    		Reactive Oxygen Species Infection Neurological Disease Inflammation/Immunology Cancer
    ROS-IN-1 is a mitochondrial ROS inhibitor. ROS-IN-1 can reduce oxidative stress or inhibit reactive oxygen species (ROS) production .
    ROS-IN-1
  • HY-148228
    ROS kinases-IN-1

    		ROS Kinase Cancer
    ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity [1].
    ROS kinases-IN-1
  • HY-W040143
    2',7'-Dichlorofluorescein

    		Reactive Oxygen Species Cancer
    2',7'-Dichlorofluorescein acts as a fluorescent probe (Ex=496 nm and Em=525 nm) for reactive oxygen species (ROS) measurement .
    2',7'-Dichlorofluorescein
  • HY-121026
    DMNQ
    4 Publications Verification

    		 Reactive Oxygen Species ROS Kinase Cardiovascular Disease
    DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production .
    DMNQ
  • HY-163200
    Cu(I) chelator 1

    		Cuproptosis Neurological Disease
    Cu(I) chelator 1 (Compound LH2) is a chelator which targets the Cu(I) redox state. Cu(I) chelator 1 prevents ROS production .
    Cu(I) chelator 1
  • HY-119502
    Camalexin
    2 Publications Verification

    		 Reactive Oxygen Species Fungal Bacterial Infection Cancer
    Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production .
    Camalexin
  • HY-N3096
    Penduletin

    		Apoptosis Reactive Oxygen Species Cancer
    Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through ROS generation .
    Penduletin
  • HY-155644
    ROS inducer 1

    		Bacterial Reactive Oxygen Species Infection
    ROS inducer 1 (compound I29) is a fungicide, with EC50 against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Pseudomonas syringae pv. actinidiae (Psa) of 5.73, 6.62 and 9.05 μg/mL. ROS inducer 1 can effectively induce the production of ROS in Xanthomonas cells and inhibit rice bacterial blight. ROS inducer 1 has the potential to study bacterial infection in crops [1].
    ROS inducer 1
  • HY-N8724
    Lamalbid

    		ROS Kinase Others
    Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .
    Lamalbid
  • HY-W009253
    Lophine

    2,4,5-Triphenylimidazole

    		 Fluorescent Dye Others
    Lophine is a traditional chemiluminescent and fluorescent probe. Lophine and its derivatives are widely applied for reactive oxygen species (ROS) detection .
    Lophine
  • HY-23119
    Sodium thiocyanate, GR, 99%

    Thiocyanate sodium

    		 Interleukin Related Reactive Oxygen Species Inflammation/Immunology
    Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of ROS formation .
    Sodium thiocyanate, GR, 99%
  • HY-121423
    Dimethachlor

    		Apoptosis Reactive Oxygen Species Metabolic Disease
    Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .
    Dimethachlor
  • HY-W654078
    Bisphenol AF-13C12

    BPAF-13C12; 4,4'-(Perfluoropropane-2,2-diyl)diphenol-13C12

    		 Isotope-Labeled Compounds Others
    Bisphenol AF- 13C12 is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels .
    Bisphenol AF-13C12
  • HY-120723
    (Rac)-Phox-I1

    		Others Others
    (Rac)-Phox-I1 is a racemic isomer of Phox-I1. Phox-I1 is a p67 phox inhibitor. Phox-I1 inhibits ROS production .
    (Rac)-Phox-I1
  • HY-155023
    Apoptosis inducer 13

    		Apoptosis Reactive Oxygen Species Cancer
    Apoptosis inducer 13 (Compound Ru4) can induce cancer cell apoptosis, and inhibits cancer cell migration and invasion. Apoptosis inducer 13 converts coenzyme NADH to NAD +, and increases intracellular ROS levels .
    Apoptosis inducer 13
  • HY-116506
    Bigelovin

    		RAR/RXR Reactive Oxygen Species Apoptosis Autophagy Cancer
    Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .
    Bigelovin
  • HY-108992
    Deoxynyboquinone

    		Apoptosis Reactive Oxygen Species Cancer
    Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .
    Deoxynyboquinone
  • HY-P5553
    cPcAMP1/26

    		Bacterial Infection
    cPcAMP1/26 is an antimicrobial peptide. cPcAMP1/26 effectively kills A.hydrophila and S. aureus. cPcAMP1/26 induces depolarization of the bacterial plasma membrane, and increases intracellular ROS levels .
    cPcAMP1/26
  • HY-N6884
    Bixin
    1 Publications Verification

    		 Reactive Oxygen Species Cardiovascular Disease Inflammation/Immunology Cancer
    Bixin (BX), isolated from the seeds of Bixa orellana, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation .
    Bixin
  • HY-159111
    KS124

    		Aldehyde Dehydrogenase (ALDH) Apoptosis Reactive Oxygen Species Cancer
    KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production .
    KS124
  • HY-121423R
    Dimethachlor (Standard)

    		Apoptosis Reactive Oxygen Species Metabolic Disease
    Dimethachlor (Standard) is the analytical standard of Dimethachlor. This product is intended for research and analytical applications. Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .
    Dimethachlor (Standard)
  • HY-126905
    ZMC3

    NSC328784

    		 Reactive Oxygen Species Cancer
    ZMC3 (NSC328784) is a zinc chelator. ZMC3 shows Zinc metallochaperone properties. ZMC3 shows enhanced sensitivity in p53-R175H mutant cells. ZMC3 increases the cell ROS level .
    ZMC3
  • HY-W015913S
    Sodium 2-oxopropanoate-13C3

    Sodium pyruvate-13C3

    		 Reactive Oxygen Species Endogenous Metabolite Metabolic Disease
    Sodium 2-oxopropanoate- 13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].
    Sodium 2-oxopropanoate-13C3
  • HY-119576
    Phox-I2

    		NADPH Oxidase Reactive Oxygen Species Inflammation/Immunology
    Phox-I2 is a selective inhibitor of p67 phox-Rac1 interaction, binds to p67 phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production .
    Phox-I2
  • HY-162364
    p38-α MAPK-IN-7

    		p38 MAPK Neurological Disease
    p38-α MAPK-IN-7 (compound 4) is a p38α-MAPK inhibitor with an IC50 value of 98.7 nM. p38-α MAPK-IN-7 protects neuronal cells from dexamethasone-induced ROS production .
    p38-α MAPK-IN-7
  • HY-135897
    Urolithin C
    4 Publications Verification

    		 Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite Metabolic Disease
    Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca 2+ channel opener and enhances Ca 2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .
    Urolithin C
  • HY-146063
    Anticancer agent 54

    		Apoptosis Cancer
    Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation .
    Anticancer agent 54
  • HY-128784
    PK11007

    		MDM-2/p53 Reactive Oxygen Species Cancer
    PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .
    PK11007
  • HY-122614
    S29434
    2 Publications Verification

    NMDPEF

    		 Autophagy Neurological Disease
    S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production .
    S29434
  • HY-146617
    GLS1 Inhibitor-4

    		Glutaminase Apoptosis Cancer
    GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM. GLS1 Inhibitor-4 shows antiproliferative activity, good metabolic stability, robust GLS1 binding affinity. GLS1 Inhibitor-4 blocks the glutamine metabolism and induce the production of ROS. GLS1 Inhibitor-4 induces apoptosis and shows antitumor activity [1].
    GLS1 Inhibitor-4
  • HY-147548
    Keap1-Nrf2-IN-10

    		Others Others
    Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice [1].
    Keap1-Nrf2-IN-10
  • HY-135425
    10,12-Tricosadiynoic acid
    3 Publications Verification

    		 Acyltransferase Metabolic Disease
    10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism . 10,12-Tricosadiynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    10,12-Tricosadiynoic acid
  • HY-120387
    SMU-B

    		ROS Kinase Anaplastic lymphoma kinase (ALK) TAM Receptor c-Met/HGFR Cancer
    SMU-B is the orally active inhibitor for ALK (IC50<0.5 nM), c-ros oncogene 1 (ROS1), c-MET (IC50=1.87 nM) and AXL (IC50=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC50s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models [1] .
    SMU-B
  • HY-B0215R
    Acetylcysteine (Standard)

    		Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis Infection Neurological Disease Cancer
    Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities . In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .
    Acetylcysteine (Standard)
  • HY-149127
    Rosolutamide

    ASC-JM17; ALZ-003

    		 Keap1-Nrf2 Androgen Receptor HSP Mitophagy Metabolic Disease
    Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby activating the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels .
    Rosolutamide
  • HY-159147
    SIA​​IS039

    		PROTACs ROS Kinase Apoptosis Cancer
    SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC50s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) [1].
    SIA​​IS039

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