2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase Anaplastic lymphoma kinase (ALK) TAM Receptor c-Met/HGFR
  4. SMU-B

SMU-B is the orally active inhibitor for ALK (IC50<0.5 nM), c-ros oncogene 1 (ROS1), c-MET (IC50=1.87 nM) and AXL (IC50=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC50s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models.

For research use only. We do not sell to patients.

SMU-B Chemical Structure

SMU-B Chemical Structure

CAS No. : 1253286-90-6

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SMU-B Related Antibodies

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Description

SMU-B is the orally active inhibitor for ALK (IC50<0.5 nM), c-ros oncogene 1 (ROS1), c-MET (IC50=1.87 nM) and AXL (IC50=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC50s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models[1][2].

IC50 & Target

IC50: <5 nM (ALK); 1.87 nM (c-MET); 28.9 nM (AXL)
Molecular Weight

515.41

Formula

C26H25Cl2FN4O2
CAS No.
SMILES

O=C1NC2=C(C=CC(C3=CC(O[C@@H](C4=C(Cl)C=CC(F)=C4Cl)C)=C(N)N=C3)=C2)C15CCN(C)CC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMU-B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMU-B1253286-90-6ROS KinaseAnaplastic lymphoma kinase (ALK)TAM Receptorc-Met/HGFRAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Tyro3AxlMernon small cell lung cancerNSCLCGTL-16MKN45H1993H441U87MGBALB/c mouseInhibitorinhibitorinhibit

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