2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. NADPH Oxidase Reactive Oxygen Species
  4. Phox-I2

Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.

For research use only. We do not sell to patients.

Phox-I2 Chemical Structure

Phox-I2 Chemical Structure

CAS No. : 353495-22-4

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1 mg USD 95 In-stock
5 mg USD 250 In-stock
10 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

Phox-I2 Related Antibodies

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Description

Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].

IC50 & Target

Kd: 150 nM (p67phox)[1]
In Vitro

Phox-I2 is effective in inhibiting NOX2-mediated superoxide production dose-dependently in dHL-60 cells and primary human neutrophils without detectable toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phox-I2 Related Antibodies
Molecular Weight

337.33

Formula

C18H15N3O4
CAS No.
Appearance

Solid

Color

Light green to green

SMILES

O=[N+]([O-])C1=CC(C2NC3=C(C4C2CC=C4)C=C(C=C3)[N+]([O-])=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (741.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9645 mL 14.8223 mL 29.6446 mL
5 mM 0.5929 mL 2.9645 mL 5.9289 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9645 mL 14.8223 mL 29.6446 mL 74.1114 mL
5 mM 0.5929 mL 2.9645 mL 5.9289 mL 14.8223 mL
10 mM 0.2964 mL 1.4822 mL 2.9645 mL 7.4111 mL
15 mM 0.1976 mL 0.9882 mL 1.9763 mL 4.9408 mL
20 mM 0.1482 mL 0.7411 mL 1.4822 mL 3.7056 mL
25 mM 0.1186 mL 0.5929 mL 1.1858 mL 2.9645 mL
30 mM 0.0988 mL 0.4941 mL 0.9882 mL 2.4704 mL
40 mM 0.0741 mL 0.3706 mL 0.7411 mL 1.8528 mL
50 mM 0.0593 mL 0.2964 mL 0.5929 mL 1.4822 mL
60 mM 0.0494 mL 0.2470 mL 0.4941 mL 1.2352 mL
80 mM 0.0371 mL 0.1853 mL 0.3706 mL 0.9264 mL
100 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7411 mL
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Phox-I2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phox-I2353495-22-4NADPH OxidaseReactive Oxygen SpeciesNOXNOX2ROSp67phoxRac1inflammationInhibitorinhibitorinhibit

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