2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 54

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation.

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Anticancer agent 54 Chemical Structure

Anticancer agent 54 Chemical Structure

CAS No. : 2933882-99-4

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Anticancer agent 54 Related Antibodies

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Description

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation[1].

In Vitro

Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC50s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively[1].
Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner[1].
Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 54 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G0/G1 phases in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: The level of the apoptotic cells increased from 7.62% to 29.33% and the population of living cells decreased from 92.01% to 55.27% at 5 µM.
Molecular Weight

516.68

Formula

C33H36N6
CAS No.
SMILES

CCCCCCCCCCN1C=C(N=N1)C2=CC=C(C=C2)C3=CC(C4=NC=CC=C4)=NC(C5=CC=CC=N5)=C3
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Room temperature in continental US; may vary elsewhere.
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References
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Anticancer agent 54 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 542933882-99-4Anticancer agent54Anticancer agent-54ApoptosisMCF-7 cellsapoptosisG0/G1ROSDNA intercalationanticancerantiproliferativeInhibitorinhibitorinhibit

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