2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. Aldehyde Dehydrogenase (ALDH) Apoptosis Reactive Oxygen Species
  4. KS124

KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production.

For research use only. We do not sell to patients.

KS124 Chemical Structure

KS124 Chemical Structure

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KS124 Related Antibodies

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Description

KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production[1].

In Vitro

KS124 (compound 3) (3 µM; 24, 48 h) induces apoptosis in a time-dependent manner in HCT-116 cells[1].
KS124 (3 µM; 48 h) increases ROS production in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KS124 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Inhibited cell viability with IC50s of 2.2, 3.8, 2.1, 8.7, 7.1 µM for HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells, respectively.

Apoptosis Analysis[1]

Cell Line: HCT-116 cells
Concentration: 3 µM
Incubation Time: 24 h, 48 h
Result: Induced apoptosis with the late apoptotic cell populations of 12.30%, 15.45% at 24, 48 h, respectively.
Molecular Weight

564.14

Formula

C21H12Br2N2O7
SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)OCC2=CC=C(CN3C(C(C4=C3C(Br)=CC(Br)=C4)=O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KS124 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS124KS 124KS-124Aldehyde Dehydrogenase (ALDH)ApoptosisReactive Oxygen SpeciesγH2AXHCT-116 cellsROSapoptosisantiproliferativeInhibitorinhibitorinhibit

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