2. NF-κB Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage Autophagy
  3. Keap1-Nrf2 Androgen Receptor HSP Mitophagy
  4. Rosolutamide

Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels.

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Rosolutamide Chemical Structure

Rosolutamide Chemical Structure

CAS No. : 1039760-91-2

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Rosolutamide Related Antibodies

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Description

Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels[1][2].

IC50 & Target[1][2]

HSF1

 

Molecular Weight

464.55

Formula

C28H32O6
CAS No.
SMILES

COC(C=C1/C=C/C(C(C(/C=C/C2=CC(OC)=C(C=C2)OC)=O)CC3CCC3)=O)=C(C=C1)OC
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Purity & Documentation
References
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Rosolutamide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosolutamide1039760-91-2ASC-JM17 ALZ-003ALZ003ALZ 003ALZ-003Keap1-Nrf2Androgen ReceptorHSPMitophagyHeat shock proteinsMitochondrial AutophagyOrallyNrf1Nrf2Hsf1antioxidant enzymemolecular chaperonespolyglutaminepolyQubiquitin-proteasomemotorspinal and bulbar muscular atrophySBMAInhibitorinhibitorinhibit

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