2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species
  4. Penduletin

Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through ROS generation.

For research use only. We do not sell to patients.

Penduletin Chemical Structure

Penduletin Chemical Structure

CAS No. : 569-80-2

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Based on 1 publication(s) in Google Scholar

Penduletin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through ROS generation[1][2].

Cellular Effect
Cell Line Type Value Description References
A2780 ADR IC50
15 μM
Compound: 15
Inhibition of P-gp expressed in A2780adr cells by calcein AM accumulation assay
Inhibition of P-gp expressed in A2780adr cells by calcein AM accumulation assay
[PMID: 21354800]
MCF7 IC50
2 μM
Compound: 15
Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining
Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining
[PMID: 21354800]
MDCK IC50
1.2 μM
Compound: 15
Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining
Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining
[PMID: 21354800]
MDCK IC50
14 μM
Compound: 15
Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometry
Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometry
[PMID: 21354800]
In Vitro

Penduletin (0-100 µg/mL, 48 h) shows antiproliferative activity against HepG2 and MCF-7 cell lines, with IC50 values of 25.8, and 6.4 µM, respectively[1].
Penduletin exhibits an enhanced ability to induce the cleavage of procaspase‐3 in HepG2 and both procaspase‐3 and procaspase‐8 in MCF-7 cells line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penduletin Related Antibodies
Molecular Weight

344.32

Formula

C18H16O7
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC=C(O)C=C3)=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

Ethanol : 5 mg/mL (14.52 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9043 mL 14.5214 mL 29.0428 mL
5 mM 0.5809 mL 2.9043 mL 5.8085 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.9043 mL 14.5214 mL 29.0428 mL 72.6069 mL
5 mM 0.5809 mL 2.9043 mL 5.8086 mL 14.5214 mL
10 mM 0.2904 mL 1.4521 mL 2.9043 mL 7.2607 mL
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Penduletin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penduletin569-80-2ApoptosisReactive Oxygen SpeciesAnticancerHepG2MCF-7Inhibitorinhibitorinhibit

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