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SHP-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SHP2 (72) Akt (1) Apoptosis (8) Autophagy (1) Bacterial (2) Casein Kinase (2) CDK (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (2) ERK (2) HDAC (1) Isotope-Labeled Compounds (1) Phosphatase (38) PROTACs (3) Reactive Oxygen Species (2)
By Research Areas:	Cancer (64) Cardiovascular Disease (2) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: SHP2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145703

SHP2 protein degrader-2	SHP2 PROTACs Phosphatase	Cancer
SHP2 protein degrader-2 (SHP2-D26) is a *SHP2* protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells .

HY-145159

SHP2 protein degrader-1	SHP2 PROTACs Phosphatase Apoptosis	Cancer
SHP2 protein degrader-1 is a potent allosteric inhibitor of *SHP2. SHP2* protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases .

HY-145162

SHP2-D26 1 Publications Verification	SHP2 PROTACs Phosphatase	Cancer
SHP2-D26 is a first, potent and effective *SHP2* degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent .

HY-125257

SHP2 inhibitor LY6 LY6	SHP2 Phosphatase	Cancer
SHP2 inhibitor LY6 (LY6) is potent and selective inhibitor of *SHP2, with an IC₅₀* of 9.8 µM. SHP2 inhibitor LY6 can inhibits SHP2-mediated cell signaling and proliferation .

HY-164427

SHP2-IN-31	SHP2 ERK	Cancer
SHP2-IN-31 is a *SHP2* inhibitor, with IC₅₀s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models .

HY-130631

SHP2-IN-5	SHP2	Cancer
SHP2-IN-5 (compound 1) is an inhibitor of SHP2 (IC₅₀: 97 nM). SHP2 is a non-receptor protein tyrosine phosphatase associated with cell growth and proliferation. SHP2-IN-5 has the potential to inhibit cancer and SHP2-related human diseases .

HY-162755

SHP2-IN-30	SHP2 Apoptosis	Cancer
SHP2-IN-30 (compound 14i) is an allosteric *SHP2* inhibitor with an IC₅₀ of 104 nM. SHP2-IN-30 shows low inhibitory effect on SHP2-PTP. SHP2-IN-30 induces cell apoptosis and arrests the cell cycle at the G0/G1 phase .

HY-155272

SHP2-IN-16	SHP2	Cancer
SHP2-IN-16 (compound 222) is a *SHP2* inhibitor with an IC₅₀ value of 1 nM. SHP2-IN-16 can be used for glioblastoma research .

HY-155273

SHP2-IN-17	SHP2	Cancer
SHP2-IN-17 (compound 192) is a *SHP2* inhibitor with an IC₅₀ value of 2 nM. SHP2-IN-17 can be used for glioblastoma research .

HY-155274

SHP2-IN-18	SHP2	Cancer
SHP2-IN-18 (compound 183) is a *SHP2* inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-18 can be used for glioblastoma research .

HY-155275

SHP2-IN-19	SHP2	Cancer
SHP2-IN-19 (compound 183) is a *SHP2* inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-19 can be used for glioblastoma research .

HY-155276

SHP2-IN-20	SHP2	Cancer
SHP2-IN-20 (compound 193) is a *SHP2* inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-20 can be used for glioblastoma research .

HY-155277

SHP2-IN-21	SHP2	Cancer
SHP2-IN-21 (compound 208) is a *SHP2* inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-21 can be used for glioblastoma research .

HY-162233

SHP2-IN-25	SHP2 Phosphatase	Cancer
SHP2-IN-25 (Compound 6) is a *SHP2* allosteric inhibitor, with an IC₅₀ of 225 nM. SHP2-IN-25 can be used for the research of cancer .

HY-144396

SHP2-IN-8	SHP2 Phosphatase Akt Apoptosis	Cancer
SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric *SHP2* inhibitor with IC₅₀ value of 23 nM and K_i of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 ℃. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells .

HY-115925

SHP2-IN-9	SHP2 Phosphatase	Cancer
SHP2-IN-9 is a specific *SHP2* inhibitor (IC₅₀ =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo .

HY-149241

SHP2-IN-13	SHP2	Cancer
SHP2-IN-13 is a highly selective and orally active SHP2 “tunnel site” allosteric inhibitor with an IC50 of 83.0 nM. SHP2-IN-13 has the potential for cancers bearing RTK oncogenic drivers and SHP2-related diseases research.

HY-162476

SHP2-IN-28	SHP2	Cancer
SHP2-IN-28 (Compound 7188-0011) is an inhibitor of *SHP2* (IC₅₀=54.31 μM). SHP2-IN-28 exerts its inhibitory effect by binding to the variable site of SHP2 with high selectivity .

HY-157888

SHP2-IN-26	SHP2 Phosphatase	Cancer
SHP2-IN-26 (Compound 4b) is a highly selective *SHP2* allosteric inhibitor with a IC₅₀ value of 3.2 nM. SHP2-IN-26 inhibits the phosphorylation of ERK and AKT in NCI-H358 cells. SHP2-IN-26 has antitumor activity .

HY-169111

SHP2-IN-32	SHP2	Cancer
SHP2-IN-32 (compound C6) is an orally active, allosteric *SHP2* inhibitor with an IC₅₀ value of 0.13 nM. SHP2-IN-32 exhibits antitumor activity .

HY-149607

SHP2-IN-22	SHP2	Cancer
SHP2-IN-22 is *SHP2* allosteric inhibitor with an IC₅₀ value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research .

HY-114460

SHP2-IN-1	SHP2 Phosphatase	Others
SHP2-IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC₅₀ of 3 nM.

HY-149759

SHP2-IN-23	SHP2 ERK	Cancer
SHP2-IN-23 (compound 30) is an orally active *SHP2* inhibitor (IC₅₀=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC₅₀=5 nM .

HY-151464

SHP2/HDAC-IN-1	SHP2 Phosphatase HDAC	Inflammation/Immunology Cancer
SHP2/HDAC-IN-1 is a dual allosteric *SHP2/HDAC* inhibitor with IC₅₀ values of 20.4 nM (SHP2) and 25.3 nM (HDAC1) respectively. SHP2/HDAC-IN-1 triggers efficient antitumor immunity by activating T cells, enhancing the antigen presentation function and promoting cytokine secretion. SHP2/HDAC-IN-1 can be used in the research of cancer immunoresearch .

HY-N12915

SHP2-IN-29	SHP2 Phosphatase	Metabolic Disease Cancer
SHP2-IN-29 (Compound 3) is a potent *SHP2* inhibitor with an IC₅₀ value of 0.18 μM. SHP2-IN-29 also has inhibitory activity against PTP1B and TCPTP, with IC₅₀ values of 4.27 and 4.74 μM, respectively.

HY-157535

SHP2-IN-24	SHP2	Cancer
SHP2-IN-24 (compound 111675) is a potent *SHP2* inhibitor with an IC₅₀ value of 0.878 µM and a K_i value of 0.118 µM .

HY-153699

SHP2-IN-14	SHP2	Cancer
SHP2-IN-14 (compound 27) is an orally active and potent *SHP2* allosteric inhibitor (IC₅₀=7 nM) with anti-tumor activity. SHP2-IN-14 inhibits tumor progression in NCI-H358 tumor bearing mice, exhibits good pharmacokinetic characteristics and safty .

HY-150609

SHP2/CDK4-IN-1	SHP2 Phosphatase CDK	Cancer
SHP2/CDK4-IN-1 (compound 10) is an orally active and potent *SHP2* and CDK4 dual inhibitor, with IC₅₀ values of 4.3 and 18.2 nM, respectively. SHP2/CDK4-IN-1 effectively induces G0/G1 arrest to prevent the proliferation of TNBC cell lines. SHP2/CDK4-IN-1 shows significant antitumor efficacy in the EMT6 syngeneic mouse model. SHP2/CDK4-IN-1 can be used for triple-negative breast cancer (TNBC) research .

HY-162355

SHP2-IN-27	SHP2	Cancer
SHP2-IN-27 (compound 28) is an allosteric inhibitor of tyrosine phosphatase *SH2* .

HY-131132

JAB-3068 SHP2-IN-6	SHP2 Phosphatase	Cancer
JAB-3068 (SHP2-IN-6) is a potent *SHP2* inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC₅₀ of 25.8 nM .

HY-131132A

JAB-3068 hydrochloride SHP2-IN-6 hydrochloride	SHP2 Phosphatase	Cancer
JAB-3068 (SHP2-IN-6) hydrochloride is a potent *SHP2* inhibitor with an IC₅₀ of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7 .

HY-141523

Vociprotafib RMC-4630; SHP2-IN-7	SHP2 Phosphatase	Cancer
Vociprotafib (RMC-4630) is an orally active, selective and potent phosphatase *SHP2* inhibitor, which blocks activation of the RAS-RAF-MEK-ERK signaling pathway with antitumor activity. Vociprotafib accelerates the time to, and increases the magnitude of, tumor regressions in Osimertinib (HY-15772)-sensitive EGFR-mutant tumors of mice ^[2] .

HY-125259

SHP504	SHP2 Phosphatase	Cancer
SHP504 is a SHP2 phosphatase inhibitor, with an IC₅₀ of 21 μM for SHP2 ^1–525 .

HY-121879

SHP836 1 Publications Verification	SHP2 Phosphatase	Cancer
SHP836 is a *SHP2* allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2 .

HY-114453

SHP389	SHP2 Phosphatase	Others
SHP389 is an allosteric *SHP2* inhibitor, with an IC₅₀ of 36 nM for both SHP2 and p-ERK .

HY-100388

SHP099 Maximum Cited Publications 60 Publications Verification	SHP2 Phosphatase	Cancer
SHP099 is an allosteric *SHP2* inhibitor, with IC₅₀s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2 ^D61Y, SHP2E69K, SHP2 ^A72V, SHP2 ^E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC₅₀: 0.32 and 1.73 μM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth ^[2].

HY-125108

PHPS1 sodium 2 Publications Verification	SHP2 Phosphatase	Cardiovascular Disease Cancer
PHPS1 sodium is a potent and selective *Shp2* inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .

HY-112368

PHPS1 2 Publications Verification	SHP2 Phosphatase	Cardiovascular Disease Cancer
PHPS1 is a potent and selective *Shp2* inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .

HY-141524

RMC-3943	SHP2 Phosphatase	Cancer
RMC-3943 is an allosteric *SHP2* inhibitor (inhibition of full-length SHP2 in biochemical assay, IC₅₀ = 2.19 nM) .

HY-112478

PTP Inhibitor IV	Phosphatase SHP2	Cancer
PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an ₅₀ of 5.21 μM . PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with ₅₀s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively ^[2].

HY-125260

SHP844	SHP2	Cancer
SHP844 is a SHP2 inhibitor with the IC₅₀ of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival .

HY-152208

BPDA2	SHP2	Cancer
BPDA2 is a highly selective and competitive active site *SHP2* inhibitor with IC₅₀s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes .

HY-N10079

Suchilactone Jatrophan	SHP2	Cancer
Suchilactone (Jatrophan) is a lignan extracted from Monsonia angustifolia E.Mey. Suchilactone binds to *SHP2* and inhibits SHP2 activation, thereby inhibiting ERK-mediated cell proliferation. Suchilactone can be ued in acute myeloid leukaemia (AML) .

HY-144903

Migoprotafib GDC-1971	SHP2 Phosphatase	Cancer
Migoprotafib (GDC-1971) (compound 199) is a *SHP2* inhibitor .

HY-101964

SPI-112	SHP2 Phosphatase	Cancer
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for *SHP2*, protein tyrosine phosphatase (PTP) and PTP1B, respectively ^[2].

HY-120901

II-B08	SHP2	Cancer
II-B08 is a reversible and noncompetitive *SHP2* inhibitor (IC₅₀: 5.5 μM, 15.7, 14.3 μM for SHP2, SHP1, PTP1B). II-B08 can be used for cancer research .

HY-100388A

SHP099 monohydrochloride Maximum Cited Publications 60 Publications Verification	SHP2 Phosphatase	Cancer
SHP099 hydrochloride is a potent, selective and orally available *SHP2* inhibitor with an IC₅₀ of 70 nM .

HY-116009

RMC-4550 4 Publications Verification	SHP2 Phosphatase	Cancer
RMC-4550 is a potent, selective and allosteric inhibitor of *SHP2, with an IC₅₀* of 0.583 nM.

HY-114397

SHP394 1 Publications Verification	SHP2 Phosphatase	Cancer
SHP394 is an orally active, selective and allosteric inhibitor of *SHP2, with an IC₅₀* of 23 nM .

HY-132901

IACS-15414	SHP2 Phosphatase	Cancer
IACS-15414 is a potent and orally bioavailable *SHP2* inhibitor with an IC₅₀ value of 122 nM.

Cat. No.	Product Name	Target	Research Area

HY-P3410

Trichomide A	SHP2 Phosphatase	Inflammation/Immunology
Trichomide A is a potent activator of *SHP2*. Trichomide A is a natural cyclodepsipeptide. Trichomide A displays immunosuppressive activity against activated T lymphocyte–mediated immune responses in Con A-activated T cells. Trichomide A have the potential for the research of immune-related skin diseases .

HY-P3444

CD31 PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of *SHP2* and to inhibit TCR-induced T-cell activation ^- .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of *SHP2* and to inhibit TCR-induced T-cell activation ^- .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0183

Ellagic acid 10+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Casein Kinase Reactive Oxygen Species Endogenous Metabolite SHP2
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of *CK2* and *SHP2, with an IC₅₀* of 40 nM and a K_i of 20 nM.

HY-N12915

SHP2-IN-29	Structural Classification Monophenols Microorganisms Source classification Phenols	SHP2 Phosphatase
SHP2-IN-29 (Compound 3) is a potent *SHP2* inhibitor with an IC₅₀ value of 0.18 μM. SHP2-IN-29 also has inhibitory activity against PTP1B and TCPTP, with IC₅₀ values of 4.27 and 4.74 μM, respectively.

HY-N10079

Suchilactone Jatrophan	Structural Classification Polygala chinensis Linnaeus Source classification Polygalaceae Lignans Phenylpropanoids Plants	SHP2
Suchilactone (Jatrophan) is a lignan extracted from Monsonia angustifolia E.Mey. Suchilactone binds to *SHP2* and inhibits SHP2 activation, thereby inhibiting ERK-mediated cell proliferation. Suchilactone can be ued in acute myeloid leukaemia (AML) .

HY-B0183R

Ellagic acid (Standard)	Structural Classification Microorganisms other families Source classification Phenols Polyphenols Plants Endogenous metabolite	Casein Kinase Reactive Oxygen Species Endogenous Metabolite SHP2
Ellagic acid (Standard) is the analytical standard of Ellagic acid. This product is intended for research and analytical applications. Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC50 of 40 nM and a Ki of 20 nM.

HY-N12177

Cryptosporioptide A	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Phosphatase
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

Recombinant Proteins Recommended:

SHP-2

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74549

	SHP-2 Protein, Mouse (HEK293, His) Tyrosine-protein phosphatase non-receptor type 11; SH-PTP2; SHP-2; Ptpn11	Mouse	HEK293
	SHP-2 Protein functions downstream of diverse receptor and cytoplasmic tyrosine kinases, participating in signal transduction from the cell surface to the nucleus.It positively regulates the MAPK pathway and dephosphorylates key proteins like GAB1, ARHGAP35, EGFR, ROCK2, CDC73, and SOX9.Additionally, SHP-2 dephosphorylates NEDD9/CAS-L to modulate cellular processes.SHP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SHP-2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700618

	SHP-2 Protein, Human (T253M, Q257L, His) protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433	Human	E. coli
	The SHP-2 protein is a key player downstream of the receptor and cytoplasmic protein tyrosine kinases, facilitating signal transduction from the cell surface to the nucleus. It actively regulates the MAPK pathway and dephosphorylates key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 ("Tyr-722"), and CDC73. SHP-2 Protein, Human (T253M, Q257L, His) is the recombinant human-derived SHP-2 protein, expressed by E. coli , with N-6*His labeled tag and T253M, Q257L, , , mutation. The total length of SHP-2 Protein, Human (T253M, Q257L, His) is 592 a.a., with molecular weight of 70-75 kDa.

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HY-B0183S

Ellagic acid-13C12
Ellagic acid- ¹³C₁₂ is ¹³ C-labeled Ellagic acid (HY-B0183). Ellagic acid is a natural antioxidant and acts as a potent and ATP-competitive inhibitor of *CK2* and *SHP2, with an IC₅₀* of 40 nM and a K_i of 20 nM ^[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81898

	SHP2 Antibody (YA1643) PTPN11; PTP2C; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; SHP2; SH-PTP3	WB, IHC-P, IP	Human
	SHP2 Antibody (YA1643) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1643), targeting SHP2, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). SHP2 Antibody (YA1643) can be used for WB, IHC-P, IP experiment in human background.

HY-P80513

	*Phospho-SHP2* (Tyr542) Antibody**	WB, ICC/IF, IP	Mouse
	Phospho-SHP2 (Tyr542) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 68 kDa, targeting to Phospho-SHP2(Y542). It can be used for WB,ICC,IP assays with tag free, in the background of Mouse.

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SHP-2

Inhibitors & Agonists

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