1. Protein Tyrosine Kinase/RTK
  2. SHP2
  3. BPDA2

BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes.

For research use only. We do not sell to patients.

BPDA2 Chemical Structure

BPDA2 Chemical Structure

CAS No. : 2907659-86-1

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Description

BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes[1].

In Vitro

BPDA2 (0.2-3.2 μM) inhibits basal activation of Akt and ERK1/2 in a concentration dependent manner[1].
BPDA2 (0.25-4.0 μM; for 10 days) suppresses the anchorage independent growth and cancer stem cell properties of breast cancer cells in a concentration dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: JIMT-1, MDA-MB468 cell
Concentration: 0.2, 0.4, 0.8, 1.6, 3.2 μM
Incubation Time:
Result: Inhibited basal activation of Akt and ERK1/2 in a concentration dependent manner.
Molecular Weight

398.49

Formula

C24H30O5

CAS No.
SMILES

CCCCCCCCCOC1=CC=C(C=C1C(O)=O)C2=CC=C(C=C2)CC(O)=O

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BPDA2
Cat. No.:
HY-152208
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