2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. CNBCA

CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study.

For research use only. We do not sell to patients.

CNBCA Chemical Structure

CNBCA Chemical Structure

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CNBCA Related Antibodies

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Description

CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study[1].

IC50 & Target

0.87 μM (SHP2)[1]
In Vitro

CNBCA (0.25, 0.50, 1, 2 μM, 48 h) inhibits SHP2 mediated Akt and ERK1/2 activation in the BT474 and MDA-MB468 cells with an approximate IC50 of 1.0 μM[1].
CNBCA (500 nM, 24-72 h) inhibits cell growth in the BT474 and MDA-MB468 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CNBCA Related Antibodies

Western Blot Analysis[1]

Cell Line: BT474 and MDA-MB468 cells
Concentration: 0.25, 0.50, 1, 2 μM
Incubation Time: 48 h
Result: Inhibited SHP2 mediated Akt and ERK1/2 activation.
Molecular Weight

426.55

Formula

C26H34O5
SMILES

OC(CCCC1=C(OCCCCCCCCC)C=CC(C2=CC=C(C(O)=O)C=C2)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CNBCA Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CNBCASHP2Src homology phosphatase 2PTPN11breast cancerpAktpERK1/2BT474MDA-MB468Inhibitorinhibitorinhibit

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