3-Azetidinemethanol hydrochloride

Name: 3-Azetidinemethanol hydrochloride
Brand: MedChemExpress
SKU: HY-21336
Rating: 4.5 (1 reviews)

Cat. No.: HY-21336 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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3-Azetidinemethanol hydrochloride, a medical intermediate, can be used in the synthesis of SHP2 inhibitor.

For research use only. We do not sell to patients.

3-Azetidinemethanol hydrochloride Chemical Structure

CAS No. : 928038-44-2

Size	Price	Stock	Quantity
250 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Purity & Documentation
References
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Description

3-Azetidinemethanol hydrochloride, a medical intermediate, can be used in the synthesis of SHP2 inhibitor^[1].

Molecular Weight

123.58

Formula

C₄H₁₀ClNO

CAS No.

928038-44-2

Appearance

Solid

Color

White to light yellow

SMILES

OCC1CNC1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (809.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.0919 mL	40.4596 mL	80.9192 mL
5 mM	1.6184 mL	8.0919 mL	16.1838 mL
10 mM	0.8092 mL	4.0460 mL	8.0919 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (20.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (20.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (20.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (392 KB)

COA (246 KB) HNMR (131 KB)

Handling Instructions (2659 KB)

References

[1]. Yi L, et, al. Substituted pyrazine compound, pharmaceutical composition comprising same, and use thereof. WO2021259077A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.0919 mL	40.4596 mL	80.9192 mL	202.2981 mL
	5 mM	1.6184 mL	8.0919 mL	16.1838 mL	40.4596 mL
	10 mM	0.8092 mL	4.0460 mL	8.0919 mL	20.2298 mL
	15 mM	0.5395 mL	2.6973 mL	5.3946 mL	13.4865 mL
	20 mM	0.4046 mL	2.0230 mL	4.0460 mL	10.1149 mL
	25 mM	0.3237 mL	1.6184 mL	3.2368 mL	8.0919 mL
	30 mM	0.2697 mL	1.3487 mL	2.6973 mL	6.7433 mL
	40 mM	0.2023 mL	1.0115 mL	2.0230 mL	5.0575 mL
	50 mM	0.1618 mL	0.8092 mL	1.6184 mL	4.0460 mL
	60 mM	0.1349 mL	0.6743 mL	1.3487 mL	3.3716 mL
	80 mM	0.1011 mL	0.5057 mL	1.0115 mL	2.5287 mL
	100 mM	0.0809 mL	0.4046 mL	0.8092 mL	2.0230 mL