JAB-3068 hydrochloride (Synonyms: SHP2-IN-6 hydrochloride)

Name: JAB-3068 hydrochloride
Brand: MedChemExpress
SKU: HY-131132A
Rating: 4.5 (1 reviews)

Cat. No.: HY-131132A Purity: 98.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC₅₀ of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7.

For research use only. We do not sell to patients.

JAB-3068 hydrochloride Chemical Structure

CAS No. : 2169223-49-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 181	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 181	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 960	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of JAB-3068 hydrochloride:

JAB-3068 Get quote

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Description

JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC₅₀ of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7^[1].

In Vitro

JAB-3068 hydrochloride inhibits the proliferation of KYSE-520 cells with an IC₅₀ of 2.17 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

513.00

Formula

C₂₂H₂₇ClF₂N₆O₂S

CAS No.

2169223-49-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(N1CC(F)(F)C2=C1C=CC=C2SC3=NC=C(N(CC4)CCC54[C@H](N)COC5)N=C3N)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 115 mg/mL (224.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9493 mL	9.7466 mL	19.4932 mL
5 mM	0.3899 mL	1.9493 mL	3.8986 mL
10 mM	0.1949 mL	0.9747 mL	1.9493 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5.75 mg/mL (11.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (57.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5.75 mg/mL (11.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (57.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.88%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (256 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Cunbo Ma, et al. Novel heterocyclic derivatives useful as shp2 inhibitors. WO2017211303A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9493 mL	9.7466 mL	19.4932 mL	48.7329 mL
	5 mM	0.3899 mL	1.9493 mL	3.8986 mL	9.7466 mL
	10 mM	0.1949 mL	0.9747 mL	1.9493 mL	4.8733 mL
	15 mM	0.1300 mL	0.6498 mL	1.2995 mL	3.2489 mL
	20 mM	0.0975 mL	0.4873 mL	0.9747 mL	2.4366 mL
	25 mM	0.0780 mL	0.3899 mL	0.7797 mL	1.9493 mL
	30 mM	0.0650 mL	0.3249 mL	0.6498 mL	1.6244 mL
	40 mM	0.0487 mL	0.2437 mL	0.4873 mL	1.2183 mL
	50 mM	0.0390 mL	0.1949 mL	0.3899 mL	0.9747 mL
	60 mM	0.0325 mL	0.1624 mL	0.3249 mL	0.8122 mL
	80 mM	0.0244 mL	0.1218 mL	0.2437 mL	0.6092 mL
	100 mM	0.0195 mL	0.0975 mL	0.1949 mL	0.4873 mL

JAB-3068 hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAB-30682169223-49-6SHP2-IN-6JAB3068JAB 3068SHP2PhosphataseSrc homology phosphatase 2PTPN11non-receptorproteintyrosinephosphatasecancerInhibitorinhibitorinhibit

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JAB-3068 hydrochloride (Synonyms: SHP2-IN-6 hydrochloride)

Customer Review

Other Forms of JAB-3068 hydrochloride:

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Biological Activity

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References

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Complete Stock Solution Preparation Table

JAB-3068 hydrochloride Related Classifications

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