2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. SHP2 Phosphatase
  4. Migoprotafib

Migoprotafib  (Synonyms: GDC-1971)

Cat. No.: HY-144903 Purity: 98.06%
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Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor.

For research use only. We do not sell to patients.

Migoprotafib Chemical Structure

Migoprotafib Chemical Structure

CAS No. : 2377352-49-1

Size Price Stock Quantity
1 mg USD 168 In-stock
5 mg USD 420 In-stock
10 mg USD 670 In-stock
25 mg USD 1350 In-stock
50 mg USD 2150 In-stock
100 mg USD 3500 In-stock
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Based on 1 publication(s) in Google Scholar

Migoprotafib Related Antibodies

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Description

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor[1].

Clinical Trial
Molecular Weight

454.53

Formula

C25H26N8O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N[C@H]1C2(CCN(C3=CN=C(C(N4C5=CC=CN=C5CCC4)=NN6)C6=N3)CC2)OC7=CC=CC=C71
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2001 mL 11.0004 mL 22.0007 mL
5 mM 0.4400 mL 2.2001 mL 4.4001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2001 mL 11.0004 mL 22.0007 mL 55.0019 mL
5 mM 0.4400 mL 2.2001 mL 4.4001 mL 11.0004 mL
10 mM 0.2200 mL 1.1000 mL 2.2001 mL 5.5002 mL
15 mM 0.1467 mL 0.7334 mL 1.4667 mL 3.6668 mL
20 mM 0.1100 mL 0.5500 mL 1.1000 mL 2.7501 mL
25 mM 0.0880 mL 0.4400 mL 0.8800 mL 2.2001 mL
30 mM 0.0733 mL 0.3667 mL 0.7334 mL 1.8334 mL
40 mM 0.0550 mL 0.2750 mL 0.5500 mL 1.3750 mL
50 mM 0.0440 mL 0.2200 mL 0.4400 mL 1.1000 mL
60 mM 0.0367 mL 0.1833 mL 0.3667 mL 0.9167 mL
80 mM 0.0275 mL 0.1375 mL 0.2750 mL 0.6875 mL
100 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5500 mL
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Migoprotafib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Migoprotafib2377352-49-1GDC-1971GDC1971GDC 1971SHP2PhosphataseSrc homology phosphatase 2PTPN11Inhibitorinhibitorinhibit

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