2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. SHP2 Phosphatase
  4. JAB-3068

JAB-3068  (Synonyms: SHP2-IN-6)

Cat. No.: HY-131132 Purity: 99.44%
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JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM.

For research use only. We do not sell to patients.

JAB-3068 Chemical Structure

JAB-3068 Chemical Structure

CAS No. : 2169223-48-5

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5 mg USD 160 In-stock
10 mg USD 250 In-stock
25 mg USD 460 In-stock
50 mg USD 690 In-stock
100 mg USD 960 In-stock
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Based on 1 publication(s) in Google Scholar

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JAB-3068 Related Antibodies

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Description

JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM[1].

In Vitro

JAB-3068 (SHP2-IN-6) inhibits the proliferation of KYSE-520 cells with an IC50 of 2.17 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JAB-3068 Related Antibodies
Molecular Weight

476.54

Formula

C22H26F2N6O2S
CAS No.
Appearance

Solid

SMILES

CC(N1CC(F)(F)C2=C1C=CC=C2SC3=NC=C(N(CC4)CCC54[C@H](N)COC5)N=C3N)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (244.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0985 mL 10.4923 mL 20.9846 mL
5 mM 0.4197 mL 2.0985 mL 4.1969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0985 mL 10.4923 mL 20.9846 mL 52.4615 mL
5 mM 0.4197 mL 2.0985 mL 4.1969 mL 10.4923 mL
10 mM 0.2098 mL 1.0492 mL 2.0985 mL 5.2461 mL
15 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4974 mL
20 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6231 mL
25 mM 0.0839 mL 0.4197 mL 0.8394 mL 2.0985 mL
30 mM 0.0699 mL 0.3497 mL 0.6995 mL 1.7487 mL
40 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3115 mL
50 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0492 mL
60 mM 0.0350 mL 0.1749 mL 0.3497 mL 0.8744 mL
80 mM 0.0262 mL 0.1312 mL 0.2623 mL 0.6558 mL
100 mM 0.0210 mL 0.1049 mL 0.2098 mL 0.5246 mL
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JAB-3068 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAB-30682169223-48-5SHP2-IN-6JAB3068JAB 3068SHP2PhosphataseSrc homology phosphatase 2PTPN11non-receptorproteintyrosinephosphatasecancerInhibitorinhibitorinhibit

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