2. Protein Tyrosine Kinase/RTK PROTAC Metabolic Enzyme/Protease
  3. SHP2 PROTACs Phosphatase
  4. SHP2 protein degrader-2

SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells.

For research use only. We do not sell to patients.

SHP2 protein degrader-2 Chemical Structure

SHP2 protein degrader-2 Chemical Structure

CAS No. : 2740582-16-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 2553 In-stock
Solution
10 mM * 1 mL in DMSO USD 2553 In-stock
Solid
1 mg USD 650 In-stock
5 mg USD 1300 In-stock
10 mg USD 2080 In-stock
25 mg USD 4380 In-stock
50 mg USD 7000 In-stock
100 mg USD 11200 In-stock
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Based on 1 publication(s) in Google Scholar

SHP2 protein degrader-2 Related Antibodies

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Description

SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].

In Vitro

SHP2 protein degrader-2 (SHP2-D26) achieves excellent degradation of SHP2 with the DC50 (the concentration where 50% of the protein has been degraded) values of 2.6 nM and 6.0 nM for MV4;11 and KYSE520 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SHP2 protein degrader-2 Related Antibodies
Molecular Weight

1115.89

Formula

C56H79ClN12O6S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (89.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8961 mL 4.4807 mL 8.9615 mL
5 mM 0.1792 mL 0.8961 mL 1.7923 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8961 mL 4.4807 mL 8.9615 mL 22.4036 mL
5 mM 0.1792 mL 0.8961 mL 1.7923 mL 4.4807 mL
10 mM 0.0896 mL 0.4481 mL 0.8961 mL 2.2404 mL
15 mM 0.0597 mL 0.2987 mL 0.5974 mL 1.4936 mL
20 mM 0.0448 mL 0.2240 mL 0.4481 mL 1.1202 mL
25 mM 0.0358 mL 0.1792 mL 0.3585 mL 0.8961 mL
30 mM 0.0299 mL 0.1494 mL 0.2987 mL 0.7468 mL
40 mM 0.0224 mL 0.1120 mL 0.2240 mL 0.5601 mL
50 mM 0.0179 mL 0.0896 mL 0.1792 mL 0.4481 mL
60 mM 0.0149 mL 0.0747 mL 0.1494 mL 0.3734 mL
80 mM 0.0112 mL 0.0560 mL 0.1120 mL 0.2800 mL
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SHP2 protein degrader-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP2 protein degrader-22740582-16-3SHP2PROTACsPhosphataseSrc homology phosphatase 2PTPN11KYSE520MV4;11anticancerInhibitorinhibitorinhibit

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SHP2 protein degrader-2
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