2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway
  3. SHP2 ERK
  4. SHP2-IN-31

SHP2-IN-31 is a SHP2 inhibitor, with IC50s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models.

For research use only. We do not sell to patients.

SHP2-IN-31 Chemical Structure

SHP2-IN-31 Chemical Structure

CAS No. : 2411321-35-0

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SHP2-IN-31 Related Antibodies

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Description

SHP2-IN-31 is a SHP2 inhibitor, with IC50s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models[1].

Molecular Weight

437.36

Formula

C21H26Cl2N4O2
CAS No.
SMILES

N[C@H]1C2(CO[C@H]1C)CCN(C3=C(C(N(C4=C(C(Cl)=CC=C4)Cl)C(C)=N3)=O)C)CC2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SHP2-IN-31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP2-IN-312411321-35-0SHP2ERKSrc homology phosphatase 2PTPN11Extracellular signal regulated kinasesInhibitorinhibitorinhibit

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