STAT5b

Isoforms Recommended:	STAT5

By Targets:	Apoptosis (2) PROTACs (1) Small Interfering RNA (siRNA) (3) STAT (7)
By Research Areas:	Cancer (6)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112648

Stafib-2	STAT	Others
Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC₅₀ of 82 nM and 1.7 μM for *STAT5b* and *STAT5a*, respectively. Stafib-2 exhibits poor cell permeability .

HY-112647

Stafib-1	STAT	Cancer
Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a K_i of 44 nM and an IC₅₀ of 154 nM .

HY-112649

Pomstafib-2	STAT Apoptosis	Cancer
Pomstafib-2 is a potent and selective *STAT5b* inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis .

HY-136546

Stafia-1 1 Publications Verification	STAT	Cancer
Stafia-1 is a potent *STAT5a* inhibitor (K_i=10.9 μM, IC₅₀=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members .

HY-19527

IST5-002 N6-Benzyladenosine-5'-phosphate	STAT Apoptosis	Cancer
IST5-002, a potent *Stat5a/b* inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC₅₀s: 1.5 μM for Stat5a, 3.5 μM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML) .

HY-148813

AK-2292	PROTACs STAT	Cancer
AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC₅₀ of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models . AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS13893

STAT5B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT5B Human Pre-designed siRNA Set A contains three designed siRNAs for STAT5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT5B Human Pre-designed siRNA Set A STAT5B Human Pre-designed siRNA Set A

HY-RS13894

Stat5b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat5b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat5b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat5b Mouse Pre-designed siRNA Set A Stat5b Mouse Pre-designed siRNA Set A

HY-RS13895

Stat5b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat5b Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat5b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat5b Rat Pre-designed siRNA Set A Stat5b Rat Pre-designed siRNA Set A

HY-170837

STAT5-IN-3	STAT	Cancer
STAT5-IN-3 (Compound 14a) is a *STAT5* inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of *STAT5A/5B* at the Y694/699 sites and significantly reduces the expression of *STAT5B* protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance .

Cat. No.	Product Name

HY-L008

*JAK/STAT* Compound Library**	523 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 523 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

523 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 523 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Compare	Product Name	Species	Source

HY-P71336

	STAT5B Protein, Human (His) Signal Transducer and Activator of Transcription 5b; STAT5b	Human	E. coli
	The STAT5B protein plays dual roles in signal transduction and transcriptional activation in response to KITLG/SCF and growth factors. STAT5B Protein, Human (His) is the recombinant human-derived STAT5B protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT5B Protein, Human (His) is 321 a.a., with molecular weight of ~38.0 kDa.

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HY-P80346

	STAT5b Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	STAT5b Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 90 kDa, targeting to STAT5b. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

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Cat. No.	Product Name		Classification

HY-RS13893

STAT5B Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
STAT5B Human Pre-designed siRNA Set A contains three designed siRNAs for STAT5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13894

Stat5b Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Stat5b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat5b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13895

Stat5b Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Stat5b Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat5b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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