1. Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  2. STAT Apoptosis
  3. Pomstafib-2

Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis.

For research use only. We do not sell to patients.

Pomstafib-2 Chemical Structure

Pomstafib-2 Chemical Structure

CAS No. : 2332841-83-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

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Description

Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2].

In Vitro

Pomstafib-2 (compound 8) (0-10 µM; 4 h) decreases the expression of pSTAT5b in a dose-dependent manner in STAT5b-GFP-transfected K562 cells[1].
Pomstafib-2 (0, 10, 20, 40, 60, 80 µM; 48 h) induces apoptosis in a dose-dependent manner in STAT5-dependent K562 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: K562 leukaemia cells
Concentration: 0, 0.3, 1, 3, 10 µM
Incubation Time: 4 h
Result: Decreased the expression of pSTAT5b in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: K562, MDA-MB-231 cells
Concentration: 0, 10, 20, 40, 60, 80 µM
Incubation Time: 48 h
Result: Induced apoptosis in a dose-dependent manner in K562 cells, does not increased the apoptotic rate of STAT5-independent MDA-MB-231 cells.
Molecular Weight

1101.03

Formula

C52H66N2O20P2

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NCC1=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)=C1)COC2=CC=C(C(NC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (158.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9082 mL 4.5412 mL 9.0824 mL
5 mM 0.1816 mL 0.9082 mL 1.8165 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9082 mL 4.5412 mL 9.0824 mL 22.7060 mL
5 mM 0.1816 mL 0.9082 mL 1.8165 mL 4.5412 mL
10 mM 0.0908 mL 0.4541 mL 0.9082 mL 2.2706 mL
15 mM 0.0605 mL 0.3027 mL 0.6055 mL 1.5137 mL
20 mM 0.0454 mL 0.2271 mL 0.4541 mL 1.1353 mL
25 mM 0.0363 mL 0.1816 mL 0.3633 mL 0.9082 mL
30 mM 0.0303 mL 0.1514 mL 0.3027 mL 0.7569 mL
40 mM 0.0227 mL 0.1135 mL 0.2271 mL 0.5677 mL
50 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.4541 mL
60 mM 0.0151 mL 0.0757 mL 0.1514 mL 0.3784 mL
80 mM 0.0114 mL 0.0568 mL 0.1135 mL 0.2838 mL
100 mM 0.0091 mL 0.0454 mL 0.0908 mL 0.2271 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pomstafib-2
Cat. No.:
HY-112649
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