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Results for "

channel-activation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (4) Potassium Channel (33) Sodium Channel (7) TRP Channel (15) Autophagy (13) Cannabinoid Receptor (9) Cholinesterase (ChE) (1) Endogenous Metabolite (10) Isotope-Labeled Compounds (5) Mitochondrial Metabolism (2) Na+/K+ ATPase (1) Parasite (5)
By Research Areas:	Cancer (4) Cardiovascular Disease (22) Endocrinology (1) Infection (5) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (29)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: FAP LAG-3 Chloride Channel Calcium Channel HCN Channel CRAC Channel TRP Channel Sodium Channel Potassium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14290A

Pinacidil monohydrate 2 Publications Verification P-1134 monohydrate	Potassium Channel	Others
Pinacidil (P-1134) monohydrate, an antihypertensive agent, is a potassium channel activator.

HY-N2164

3-Deoxyaconitine	Sodium Channel	Others
3-Deoxyaconitine a diterpenoid alkaloid, is a sodium channel activator .

HY-B1140

Diazoxide 3 Publications Verification Sch-6783; SRG-95213	Potassium Channel Autophagy	Cardiovascular Disease Cancer
Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.

HY-13103

NS 11021 1 Publications Verification	Potassium Channel	Others
NS 11021 is a potent and specific Ca ²⁺-activated big-conductance K ⁺ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials .

HY-P5174

MitTx	Sodium Channel	Neurological Disease
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC₅₀ values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation .

HY-146173

*KCa1.1 channel* activator-1**	Potassium Channel Calcium Channel	Cardiovascular Disease
KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular K_Ca1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays Ca_V1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity .

HY-146174

*KCa1.1 channel* activator-2**	Potassium Channel	Cardiovascular Disease
KCa1.1 channel activator-2 (compound 3F), a Quercetin hybrid derivative, is a selective vascular K_Ca1.1 channel stimulator. KCa1.1 channel activator-2 exhibits potent myorelaxant activity .

HY-113654

AMG 7905	Others	Others
AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin .

HY-N8716

Grayanotoxin I	Sodium Channel	Cardiovascular Disease
Grayanotoxin I is a voltage-gated sodium channel activator that can be isolated from Pieris japonica .

HY-118172

PD-307243	Potassium Channel	Cardiovascular Disease
PD-307243 is a hERG channel activator. PD-307243 can be used for research of arrhythmias .

HY-107301

Dehydrosoyasaponin I Soyasaponin Be; DHS-I	Potassium Channel	Neurological Disease
Dehydrosoyasaponin I (Soyasaponin Be;DHS-I), a triterpene glycoside, is a potent and reversible calcium-activated potassium (maxi-K) channels activator .

HY-B1140S

Diazoxide-d3 Sch-6783-d₃; SRG-95213-d₃	Isotope-Labeled Compounds Potassium Channel Autophagy	Cardiovascular Disease
Diazoxide-d₃ is deuterium labeled Diazoxide. Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.

HY-B0887C

1R-cis-Permethrin 1R-cis-NRDC-143	Parasite	Infection
1R-cis-Permethrin is an insecticide and neurotoxin. 1R-cis-Permethrin affects neuron membranes by prolonging sodium channel activation .

HY-B1140R

Diazoxide (Standard)	Potassium Channel Autophagy	Cardiovascular Disease Cancer
Diazoxide (Standard) is the analytical standard of Diazoxide. This product is intended for research and analytical applications. Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.

HY-101069

Y-26763 1 Publications Verification	Potassium Channel	Cardiovascular Disease
Y-26763 is a K ⁺ channel opener and active metabolite of Y-27152 . Y-26763 is an ATP-sensitive K ⁺ (K_ATP) channel activator .

HY-108594

PD-118057	Potassium Channel	Metabolic Disease
PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability .

HY-B0887S1

Permethrin-d9 NRDC-143-d₉	Isotope-Labeled Compounds Parasite	Infection
Permethrin-d₉ is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.

HY-116759

VU0405601	Potassium Channel	Cardiovascular Disease
VU0405601 is a potent KV11.1 channel activator. VU0405601 protects cardiac tissue from dofetilide (HY-B0232)-induced ventricular tachycardia .

HY-B0887R

Permethrin (Standard)	Parasite Mitochondrial Metabolism	Infection Neurological Disease
Permethrin (Standard) is the analytical standard of Permethrin. This product is intended for research and analytical applications. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.

HY-116119

BDF 9148	Sodium Channel	Cardiovascular Disease
BDF 9148 is a *sodium-channel* activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing human hearts. BDF 9148 is promising for research of myocardial failure .

HY-110153

NS19504	Potassium Channel	Neurological Disease
NS19504 is a Ca ²⁺-activated K ⁺ channel (BK channel, KCa1.1 channel) activator (EC₅₀=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions .

HY-N2433

Paederosidic acid methyl ester	Potassium Channel	Neurological Disease
Paederosidic acid methyl ester is a ATP‐sensitive K ⁺ channel activator, isolated from P. scandens. Paederosidic acid methyl ester exhibits significant central analgesic activity, and enhances the threshold of pain by activating ATP‐sensitive K ⁺ channel in the brain and spinal cord level .

HY-U00280

*Potassium Channel* Activator 1**	Others	Neurological Disease
Potassium Channel Activator 1 is an agent for treating, one or more disorders or conditions wherein the dopaminergic system is disrupted, such as one or more disorders or conditions independently selected from the group consisting of: schizophrenia and other psychotic states; mood disorders ADHD; aggression; movement disorders.

HY-B0887S

Permethrin-d5 NRDC-143-d₅	Parasite	Infection
Permethrin-d₅ (NRDC-143-d5) is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation[1][2].

HY-107757

GMQ	Sodium Channel	Neurological Disease
GMQ is a ASIC (acid-sensing ion) channel activator with an EC₅₀ value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research .

HY-B0341

Nicorandil SG-75	Potassium Channel	Cardiovascular Disease
Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K ⁺ channels and cardiac ATP-sensitive K ⁺ channels (K_ATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

HY-113673

A-935142	Potassium Channel	Cardiovascular Disease
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization .

HY-12550

GW542573X	Potassium Channel	Neurological Disease
GW542573X is a potent and selective Ca ²⁺-activated K ⁺ 2 (SK2) channels activator. GW542573X induces the Ca ²⁺-response curve of hSK1 that left-shifted from an EC₅₀ (Ca ²⁺) value of 410 nM to 240 nM .

HY-122024

AZSMO-23	Potassium Channel	Cardiovascular Disease
AZSMO-23 is a potent hERG K ⁺ channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC₅₀ values of 28.6, 11.2 µM, respectively. AZSMO-23 has the potential for the research of long QT syndrome .

HY-12343

ML277 CID-53347902	Potassium Channel	Cardiovascular Disease
ML277 (CID-53347902) is a potent and selective activator of K(v)7.1 (KCNQ1) potassium channel activator (EC₅₀=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes .

HY-100345

AMTB hydrochloride 1 Publications Verification	TRP Channel	Neurological Disease Cancer
AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC₅₀ of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (Na_V) .

HY-100973A

Adenosine 5′-diphosphoribose sodium 2 Publications Verification ADP ribose sodium	TRP Channel Autophagy	Metabolic Disease Endocrinology Cancer
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .

HY-129445

SG-209	Potassium Channel	Cardiovascular Disease
SG-209 is a Nicorandil (HY-B0341) derivative that produces relaxation through potassium channel activation, while this action contributes to the vasodilating action of Nicorandil (HY-B0341) at higher concentrations. SG-209 dilates tracheal smooth muscle and increases tracheal blood flow in anesthetized dogs .

HY-109545

Isopropyl unoprostone Unoprostone isopropyl ester; UF-021	Potassium Channel	Others
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca ²⁺-activated K ⁺ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity .

HY-19216

KR-30450 SKP 450	Potassium Channel	Cardiovascular Disease
KR-30450 (SKP 450) is a potent K ⁺_ATP opener, and a potassium channel activator. KR-30450 exerts more potent cardioprotective effects than Lemakalim (HY-14255). KR-30450 significantly improves reperfusion cardiac function. KR-30450 significantly attenuates reperfusion contracture and lactate dehydrogenase release .

HY-B0341R

Nicorandil (Standard)	Potassium Channel	Cardiovascular Disease
Nicorandil (Standard) is the analytical standard of Nicorandil. This product is intended for research and analytical applications. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K ⁺ channels and cardiac ATP-sensitive K ⁺ channels (K_ATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

HY-108591

L-364,373 R-L3	Potassium Channel	Cardiovascular Disease
L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .

HY-108587

ICA 110381	Potassium Channel	Neurological Disease
ICA 110381 is an orally active Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC₅₀=0.38 μM) as well as KCNQ1 antagonist (IC₅₀=15 μM) .

HY-B0887

Permethrin 1 Publications Verification NRDC-143	Parasite Mitochondrial Metabolism Sodium Channel Na+/K+ ATPase	Infection Neurological Disease
Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes) .

HY-B0341S

Nicorandil-d4	Isotope-Labeled Compounds Potassium Channel	Cardiovascular Disease
Nicorandil-d₄ (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].

HY-111655

SKA-31 3 Publications Verification	Potassium Channel	Cardiovascular Disease
SKA-31 is a potent potassium channel activator with EC_50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure .

HY-164417

Kv7.2/Kv7.3 activator-1	Potassium Channel	Neurological Disease
Kv7.2/Kv7.3 activator-1 (compound 517) is a potent Kv7.2/Kv7.3 channel activator with an EC₅₀ value of ＜1 µM. Kv7.2/Kv7.3 activator-1 has the potential for the research of neurological diseases .

HY-124702

ICA-105574	Potassium Channel	Cardiovascular Disease
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC₅₀ value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2 .

HY-108573

P-1075 1 Publications Verification	Potassium Channel	Cardiovascular Disease
P-1075 is a potent activator of *sulfonylurea receptor 2-associated ATP-sensitive potassium channels* (SUR2-K_IR6), with an EC₅₀** value of 45 nM for SUR2B-K_IR6 channel activation . P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts .

HY-117931

NS004	Potassium Channel	Neurological Disease
NS004 is a potassium (BK) channel activator that increases Iberiotoxin (HY-P0190) or Tetraethylammonium (HY-B1793)-sensitive whole-cell efflux currents. NS004 also significantly increased the activity of individual GH3 cell BK channels and rat brain BK channels reorganized into planar lipid bilayers, causing an increase in channel mean open time, a decrease in intermittent time, and an increase in channel voltage/calcium sensitivity .

HY-B0151

Pregnenolone 2 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-B1739

Pregnenolone monosulfate 3β-Hydroxy-5-pregnen-20-one monosulfate	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication . Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-110189

Pregnenolone monosulfate sodium 2 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺?channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

HY-101396

ICA-069673 2 Publications Verification	Potassium Channel	Neurological Disease
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC₅₀s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells .

Cat. No.	Product Name	Target	Research Area

HY-P5174

MitTx	Sodium Channel	Neurological Disease
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC₅₀ values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation .

HY-P5808

Iota-conotoxin RXIA	Peptides	Neurological Disease
lota-conotoxin RXIA is an agonist of voltage-gated sodium channels (Na_v1.2, 1.6, 1.7). Iota-conotoxin RXIA can induce repetitive action potential and seizure in motor axons of frogs after intracranial injection in mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2164

3-Deoxyaconitine	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Ranunculaceae Source classification Other Diseases Aconitum carmichaeli Debx. Plants Disease Research Fields	Sodium Channel
3-Deoxyaconitine a diterpenoid alkaloid, is a sodium channel activator .

HY-N2433

Paederosidic acid methyl ester	Iridoids Terpenoids Paederia scandens (Lour.) Merr. Source classification Rubiaceae Plants	Potassium Channel
Paederosidic acid methyl ester is a ATP‐sensitive K ⁺ channel activator, isolated from P. scandens. Paederosidic acid methyl ester exhibits significant central analgesic activity, and enhances the threshold of pain by activating ATP‐sensitive K ⁺ channel in the brain and spinal cord level .

HY-B0151

Pregnenolone 2 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Anti-aging Source classification Endogenous metabolite Disease Research Fields Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-110189

Pregnenolone monosulfate sodium 2 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Structural Classification Source classification Endogenous metabolite Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-12545

Brevetoxin-3 PbTx-3	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Sodium Channel
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺?channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

HY-116330A

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	Structural Classification Natural Products Guttiferae Source classification Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-B0151R

Pregnenolone (Standard) 2 Publications Verification 3β-Hydroxy-5-pregnen-20-one (Standard)	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Endogenous metabolite Disease Research Fields Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-N8716

Grayanotoxin I	Structural Classification Terpenoids Source classification Diterpenoids Kalmia latifolia L. Plants Ericaceae	Sodium Channel
Grayanotoxin I is a voltage-gated sodium channel activator that can be isolated from Pieris japonica .

HY-107301

Dehydrosoyasaponin I Soyasaponin Be; DHS-I	Structural Classification Polysaccharides Leguminosae Source classification Plants Saccharides Medicago sativa L.	Potassium Channel
Dehydrosoyasaponin I (Soyasaponin Be;DHS-I), a triterpene glycoside, is a potent and reversible calcium-activated potassium (maxi-K) channels activator .

HY-B1739

Pregnenolone monosulfate 3β-Hydroxy-5-pregnen-20-one monosulfate	Structural Classification Source classification Endogenous metabolite Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication . Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .

HY-116330

Hyperforin	Structural Classification Anti-inflammation/Immunoregulatory Antibiotics Guttiferae Source classification Hyperlcurn perforatum L. Disease Research Plants Anticancer	Calcium Channel TRP Channel
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-116330AR

Hyperforin dicyclohexylammonium salt (Standard)	Structural Classification Natural Products Guttiferae Source classification Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin (dicyclohexylammonium salt) (Standard) is the analytical standard of Hyperforin (dicyclohexylammonium salt). This product is intended for research and analytical applications. Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

Cat. No.	Product Name	Chemical Structure

HY-B0887S

Permethrin-d5
Permethrin-d₅ (NRDC-143-d5) is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation[1][2].

HY-B0341S

Nicorandil-d4
Nicorandil-d₄ (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].

HY-B0151S2

Pregnenolone-d4-1

Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

HY-B1140S

Diazoxide-d3
Diazoxide-d₃ is deuterium labeled Diazoxide. Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.

HY-B0887S1

Permethrin-d9
Permethrin-d₉ is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.

HY-B0151S1

Pregnenolone-13C2,d2

Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[1][2][3][4].

HY-B0151S

Pregnenolone-d4

Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

HY-110189S1

Pregnenolone monosulfate-d4 sodium

Pregnenolone monosulfate-d₄ (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

HY-110189S

Pregnenolone monosulfate sodium-13C2,d2

Pregnenolone monosulfate (sodium)- ¹³C₂,d₂ is the ¹³C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

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