2. GPCR/G Protein Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease Autophagy
  3. Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
  4. Pregnenolone-d4-1

Pregnenolone-d4-1  (Synonyms: 3β-Hydroxy-5-pregnen-20-one-d4-1)

Cat. No.: HY-B0151S2 Purity: 99%
SDS COA Handling Instructions

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Pregnenolone-d4-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

For research use only. We do not sell to patients.

Pregnenolone-d<sub>4</sub>-1 Chemical Structure

Pregnenolone-d4-1 Chemical Structure

CAS No. : 61574-54-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 484 In-stock
Solution
10 mM * 1 mL in DMSO USD 484 In-stock
Solid
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5 mg USD 440 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pregnenolone-d4-1:

Pregnenolone-d4-1 Related Antibodies

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View All Cannabinoid Receptor Isoform Specific Products:

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CB1 CB2

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TRPC TRPM TRPV TRPA TRPML

  • Biological Activity

  • Purity & Documentation

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Description

Pregnenolone-d4-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pregnenolone-d4-1 Related Antibodies
Molecular Weight

320.50

Formula

C21H28D4O2
CAS No.
Unlabeled CAS

145-13-1
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([2H])C(C([2H])([2H])[2H])=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (97.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1201 mL 15.6006 mL 31.2013 mL
5 mM 0.6240 mL 3.1201 mL 6.2402 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99%

SDS (252 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1201 mL 15.6006 mL 31.2012 mL 78.0031 mL
5 mM 0.6240 mL 3.1201 mL 6.2402 mL 15.6006 mL
10 mM 0.3120 mL 1.5601 mL 3.1201 mL 7.8003 mL
15 mM 0.2080 mL 1.0400 mL 2.0801 mL 5.2002 mL
20 mM 0.1560 mL 0.7800 mL 1.5601 mL 3.9002 mL
25 mM 0.1248 mL 0.6240 mL 1.2480 mL 3.1201 mL
30 mM 0.1040 mL 0.5200 mL 1.0400 mL 2.6001 mL
40 mM 0.0780 mL 0.3900 mL 0.7800 mL 1.9501 mL
50 mM 0.0624 mL 0.3120 mL 0.6240 mL 1.5601 mL
60 mM 0.0520 mL 0.2600 mL 0.5200 mL 1.3001 mL
80 mM 0.0390 mL 0.1950 mL 0.3900 mL 0.9750 mL
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Pregnenolone-d4-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pregnenolone-d4-161574-54-73β-Hydroxy-5-pregnen-20-one-d4-1Cannabinoid ReceptorTRP ChannelEndogenous MetaboliteAutophagyTransient receptor potential channelsInhibitorinhibitorinhibit

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