2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. NS004

NS004 is a potassium (BK) channel activator that increases Iberiotoxin (HY-P0190) or Tetraethylammonium (HY-B1793)-sensitive whole-cell efflux currents. NS004 also significantly increased the activity of individual GH3 cell BK channels and rat brain BK channels reorganized into planar lipid bilayers, causing an increase in channel mean open time, a decrease in intermittent time, and an increase in channel voltage/calcium sensitivity.

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NS004 Chemical Structure

NS004 Chemical Structure

CAS No. : 141797-92-4

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Based on 1 publication(s) in Google Scholar

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Description

NS004 is a potassium (BK) channel activator that increases Iberiotoxin (HY-P0190) or Tetraethylammonium (HY-B1793)-sensitive whole-cell efflux currents. NS004 also significantly increased the activity of individual GH3 cell BK channels and rat brain BK channels reorganized into planar lipid bilayers, causing an increase in channel mean open time, a decrease in intermittent time, and an increase in channel voltage/calcium sensitivity[1].

Molecular Weight

328.67

Formula

C14H8ClF3N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=C(C=C2N1)C(F)(F)F)C3=CC(Cl)=CC=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (380.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0426 mL 15.2128 mL 30.4257 mL
5 mM 0.6085 mL 3.0426 mL 6.0851 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0426 mL 15.2128 mL 30.4257 mL 76.0641 mL
5 mM 0.6085 mL 3.0426 mL 6.0851 mL 15.2128 mL
10 mM 0.3043 mL 1.5213 mL 3.0426 mL 7.6064 mL
15 mM 0.2028 mL 1.0142 mL 2.0284 mL 5.0709 mL
20 mM 0.1521 mL 0.7606 mL 1.5213 mL 3.8032 mL
25 mM 0.1217 mL 0.6085 mL 1.2170 mL 3.0426 mL
30 mM 0.1014 mL 0.5071 mL 1.0142 mL 2.5355 mL
40 mM 0.0761 mL 0.3803 mL 0.7606 mL 1.9016 mL
50 mM 0.0609 mL 0.3043 mL 0.6085 mL 1.5213 mL
60 mM 0.0507 mL 0.2535 mL 0.5071 mL 1.2677 mL
80 mM 0.0380 mL 0.1902 mL 0.3803 mL 0.9508 mL
100 mM 0.0304 mL 0.1521 mL 0.3043 mL 0.7606 mL
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NS004 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS004141797-92-4NS 004NS-004Potassium ChannelKcsAInhibitorinhibitorinhibit

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