2. Signaling Pathways
  3. Immunology/Inflammation
  4. FAP

FAP

Fibroblast activation protein

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137331
    FAPI-46
    		98.57%
    FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.
    FAPI-46
  • HY-101801
    Ac-Gly-BoroPro
    		≥98.0%
    Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
    Ac-Gly-BoroPro
  • HY-128643
    FAPI-4
    		98.42%
    FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios.
    FAPI-4
  • HY-147057
    FAP-2286
    		99.54%
    FAP-2286 is a potent and selective FAP-binding peptide coupled to a radionuclide chelator with a mean IC50 value of 2.7 nM for binding to FAP. FAP-2286 can chelate radionuclides for imaging or therapeutic applications and has a strong effect on FAP-positive tumors. FAP-2286 can be used for FAP-positive tumor research.
    FAP-2286
  • HY-P99269
    Sibrotuzumab
    Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targets fibroblast activation protein (FAP). Sibrotuzumab can be used for the research of colorectal cancer and non-small cell lung cancer (NSCLC).
    Sibrotuzumab
  • HY-164364A
    DOTAGA.(SA.FAPi)2 TFA
    		Inhibitor
    DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi). DOTAGA.(SA.FAPi)2 TFA has the potential for cancer diagnosis research.
    DOTAGA.(SA.FAPi)2 TFA
  • HY-164725
    FAPI-mFS
    		Inhibitor 99.78%
    FAPI-mFS is an irreversible fibroblast activation protein (FAP) inhibitor, that enhances the uptake and retention time in cancer cells through its covalent binding property for FAP. FAPI-mFS can be used for cancer imaging the therapy, when labeled with radioactive 68Ga or 177Lu. FAPI-mFS can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    FAPI-mFS
  • HY-D2363
    DOTA.SA.FAPi TFA
    		Inhibitor 99.26%
    DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC50 of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC50 of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with 68Ga, and used for research about cancer. DOTA.SA.FAPi (TFA) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    DOTA.SA.FAPi TFA
  • HY-145983
    Suc-Gly-Pro-AMC
    		99.16%
    Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP)-specific substrate. Suc-Gly-Pro-AMC can be used to study the activity of FAP.
    Suc-Gly-Pro-AMC
  • HY-153552A
    NH2-UAMC1110 TFA
    		Inhibitor 99.89%
    NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors.
    NH2-UAMC1110 TFA
  • HY-145938
    OncoFAP
    		99.77%
    OncoFAP is an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential.
    OncoFAP
  • HY-100684
    UAMC-1110
    		Inhibitor 99.58%
    UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM; also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.
    UAMC-1110
  • HY-147173
    FAPI-74
    		99.84%
    FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP). FAPI-74 can be used for FAP-positive tumor research.
    FAPI-74
  • HY-47979A
    FAP-IN-2 TFA
    		Inhibitor 99.92%
    FAP-IN-2 TFA is a 99mTc-labeled isonitrile-containing FAP inhibitor derivative that can be used for tumor imaging.
    FAP-IN-2 TFA
  • HY-P10131
    3BP-3940
    		99.96%
    3BP-3940 is a highly potent fibroblast activation protein (FAP)-targeting peptide for theranostics. 3BP-3940 is often coupled with radionuclides for tumor diagnosis and treatment. 3BP-3940 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    3BP-3940
  • HY-136641
    NOTA-FAPI
    		Inhibitor 99.26%
    NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI can be used as a probe for FAP-targeted tumour imaging. NOTA-FAPI has good tumour detection efficacy and excellent imaging quality.
    NOTA-FAPI
  • HY-47979
    FAP-IN-2
    		Inhibitor 99.82%
    FAP-IN-2 is a derivative of 99mTc-labeled isonitrile-containing fibroblast activation protein (FAPI) inhibitor, that can be used for tumor imaging.
    FAP-IN-2
  • HY-164316
    FT-FAPI-12_9
    FT-FAPI-12_9 is a FAP-binding moiety, which can be used for synthesis of FAP-targeted radiotracer FAPI-46 (HY-137331).
    FT-FAPI-12_9
  • HY-139401
    FAPI-34
    		99.67%
    FAPI-34 is a fibroblast-activating protein (FAP) inhibitor with favorable pharmacokinetic and biochemical properties. (patent WO2019154886A1).
    FAPI-34
  • HY-128642
    FAPI-2
    		98.94%
    FAPI-2 is a type of small molecule fibroblast activation protein inhibitor (FAPI) that targets the fibroblast activation protein (FAP) and has an inhibitory effect. This specific targeting ability makes FAPI-2 an effective tumor imaging agent, which can be used in cancer research. FAPI-2 can be used to synthesize 68Ga-FAPI-2 (a PET tracer).
    FAPI-2
Cat. No. Product Name / Synonyms Application Reactivity