2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPC6-PAM-C20

TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals.

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TRPC6-PAM-C20 Chemical Structure

TRPC6-PAM-C20 Chemical Structure

CAS No. : 667427-75-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 605 In-stock
Solution
10 mM * 1 mL in DMSO USD 605 In-stock
Solid
1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 910 In-stock
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Based on 1 publication(s) in Google Scholar

TRPC6-PAM-C20 Related Antibodies

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Description

TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1].

IC50 & Target

EC50: 2.37 μM (TRPC6-expressing HEK293 cells)[1]
Molecular Weight

363.41

Formula

C22H21NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C2=NC(C)(C)CC3=C2C=C(OC)C(OC)=C3)=CC4=CC=CC=C4O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (91.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7517 mL 13.7586 mL 27.5171 mL
5 mM 0.5503 mL 2.7517 mL 5.5034 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7517 mL 13.7586 mL 27.5171 mL 68.7928 mL
5 mM 0.5503 mL 2.7517 mL 5.5034 mL 13.7586 mL
10 mM 0.2752 mL 1.3759 mL 2.7517 mL 6.8793 mL
15 mM 0.1834 mL 0.9172 mL 1.8345 mL 4.5862 mL
20 mM 0.1376 mL 0.6879 mL 1.3759 mL 3.4396 mL
25 mM 0.1101 mL 0.5503 mL 1.1007 mL 2.7517 mL
30 mM 0.0917 mL 0.4586 mL 0.9172 mL 2.2931 mL
40 mM 0.0688 mL 0.3440 mL 0.6879 mL 1.7198 mL
50 mM 0.0550 mL 0.2752 mL 0.5503 mL 1.3759 mL
60 mM 0.0459 mL 0.2293 mL 0.4586 mL 1.1465 mL
80 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8599 mL
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TRPC6-PAM-C20 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPC6-PAM-C20667427-75-0TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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