2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. A-935142

A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization.

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A-935142 Chemical Structure

A-935142 Chemical Structure

CAS No. : 1031335-85-9

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Based on 1 publication(s) in Google Scholar

A-935142 Related Antibodies

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Description

A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization[1][2].

In Vitro

A-935142 shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers[1].
A-935142 shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner. A-935142 (60μM) increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation. A-935142 significantly reduces the time constants τ of hERG channel activation at two example voltages (-10 mV: tau=100+/-17 ms vs. 164+/-24 ms, n=6, P<0.01; +30 mV: tau=16.7+/-1.8 ms vs. 18.9+/-1.8 ms, n=5, P<0.05) and shifts the voltage-dependence for hERG activation in the hyperpolarizing direction by 9 mV[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A-935142 Related Antibodies
Molecular Weight

352.35

Formula

C18H19F3N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C[C@H]1CC[C@H](C2=CC=C(C3=NNC(C(F)(F)F)=C3)C=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (354.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8381 mL 14.1904 mL 28.3809 mL
5 mM 0.5676 mL 2.8381 mL 5.6762 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8381 mL 14.1904 mL 28.3809 mL 70.9522 mL
5 mM 0.5676 mL 2.8381 mL 5.6762 mL 14.1904 mL
10 mM 0.2838 mL 1.4190 mL 2.8381 mL 7.0952 mL
15 mM 0.1892 mL 0.9460 mL 1.8921 mL 4.7301 mL
20 mM 0.1419 mL 0.7095 mL 1.4190 mL 3.5476 mL
25 mM 0.1135 mL 0.5676 mL 1.1352 mL 2.8381 mL
30 mM 0.0946 mL 0.4730 mL 0.9460 mL 2.3651 mL
40 mM 0.0710 mL 0.3548 mL 0.7095 mL 1.7738 mL
50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4190 mL
60 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1825 mL
80 mM 0.0355 mL 0.1774 mL 0.3548 mL 0.8869 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7095 mL
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A-935142 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-9351421031335-85-9A935142A 935142Potassium ChannelKcsAcurrentamplitudevoltagecomplexInhibitorinhibitorinhibit

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