AZSMO-23

Cat. No.: HY-122024 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

AZSMO-23 is a potent hERG K⁺ channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC₅₀ values of 28.6, 11.2 µM, respectively. AZSMO-23 has the potential for the research of long QT syndrome.

For research use only. We do not sell to patients.

AZSMO-23 Chemical Structure

CAS No. : 496793-75-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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References
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Description

In Vitro

AZSMO-23 blocks hKv4.3-hKChIP2.2, hCav3.2 and hKv1.5 and activats hCav1.2/β2/α2δ channels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

348.79

Formula

C₁₉H₁₃ClN₄O

CAS No.

496793-75-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=CN=C1)NC2=CC=C(Cl)C(C3=NC4=CC=CC=C4N3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5.83 mg/mL (16.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8671 mL	14.3353 mL	28.6705 mL
5 mM	0.5734 mL	2.8671 mL	5.7341 mL
10 mM	0.2867 mL	1.4335 mL	2.8671 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (251 KB) HNMR (259 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Mannikko R, et al. Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel. Br J Pharmacol. 2015 Jun;172(12):3112-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8671 mL	14.3353 mL	28.6705 mL	71.6764 mL
	5 mM	0.5734 mL	2.8671 mL	5.7341 mL	14.3353 mL
	10 mM	0.2867 mL	1.4335 mL	2.8671 mL	7.1676 mL
	15 mM	0.1911 mL	0.9557 mL	1.9114 mL	4.7784 mL

AZSMO-23 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZSMO-23496793-75-0AZSMO23AZSMO 23Potassium ChannelKcsAlong QT syndromepre-pulsetail currentInhibitorinhibitorinhibit

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