2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. ICA-105574

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2.

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ICA-105574 Chemical Structure

ICA-105574 Chemical Structure

CAS No. : 316146-57-3

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Description

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2[1].

Molecular Weight

334.33

Formula

C19H14N2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (747.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9911 mL 14.9553 mL 29.9106 mL
5 mM 0.5982 mL 2.9911 mL 5.9821 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9911 mL 14.9553 mL 29.9106 mL 74.7764 mL
5 mM 0.5982 mL 2.9911 mL 5.9821 mL 14.9553 mL
10 mM 0.2991 mL 1.4955 mL 2.9911 mL 7.4776 mL
15 mM 0.1994 mL 0.9970 mL 1.9940 mL 4.9851 mL
20 mM 0.1496 mL 0.7478 mL 1.4955 mL 3.7388 mL
25 mM 0.1196 mL 0.5982 mL 1.1964 mL 2.9911 mL
30 mM 0.0997 mL 0.4985 mL 0.9970 mL 2.4925 mL
40 mM 0.0748 mL 0.3739 mL 0.7478 mL 1.8694 mL
50 mM 0.0598 mL 0.2991 mL 0.5982 mL 1.4955 mL
60 mM 0.0499 mL 0.2493 mL 0.4985 mL 1.2463 mL
80 mM 0.0374 mL 0.1869 mL 0.3739 mL 0.9347 mL
100 mM 0.0299 mL 0.1496 mL 0.2991 mL 0.7478 mL
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ICA-105574 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICA-105574316146-57-3ICA105574ICA 105574Potassium ChannelKcsAhERG channelactivatorcurrent amplitudesInhibitorinhibitorinhibit

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