Pinacidil monohydrate (Synonyms: P-1134 monohydrate)

Name: Pinacidil monohydrate
Brand: MedChemExpress
SKU: HY-14290A
Rating: 5.0 (4 reviews)

Cat. No.: HY-14290A Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pinacidil (P-1134) monohydrate, an antihypertensive agent, is a potassium channel activator.

For research use only. We do not sell to patients.

Pinacidil monohydrate Chemical Structure

CAS No. : 85371-64-8

Size	Price	Stock	Quantity
5 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 56	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 157	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 235	In-stock	Estimated Time of Arrival: December 31
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Based on 4 publication(s) in Google Scholar

Other Forms of Pinacidil monohydrate:

Pinacidil Get quote

4 Publications Citing Use of MCE Pinacidil monohydrate

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Description

Pinacidil (P-1134) monohydrate, an antihypertensive agent, is a potassium channel activator.

In Vitro

Pinacidil monohydrate is a potassium channel activator^[1]. Pinacidil hydrate is an antihypertensive drug of the class of agents called "potassium channel openers"^[2]. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with K_i values of 104 and 251 nM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

263.34

Formula

C₁₃H₂₁N₅O

CAS No.

85371-64-8

Appearance

Solid

Color

White to off-white

SMILES

[H]O[H].CC(C)(C)C(N/C(NC#N)=N/C1=CC=NC=C1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (379.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (189.87 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7974 mL	18.9869 mL	37.9737 mL
5 mM	0.7595 mL	3.7974 mL	7.5947 mL
10 mM	0.3797 mL	1.8987 mL	3.7974 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 4

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.83 mg/mL (6.95 mM); Clear solution

This protocol yields a clear solution of ≥ 1.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (18.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 5

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.83 mg/mL (6.95 mM); Clear solution

This protocol yields a clear solution of ≥ 1.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (18.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 6

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.83 mg/mL (6.95 mM); Clear solution

This protocol yields a clear solution of ≥ 1.83 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (18.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (252 KB) HNMR (383 KB) RP-HPLC (207 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86. [Content Brief]

[2]. Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5. [Content Brief]

[3]. Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	3.7974 mL	18.9869 mL	37.9737 mL	94.9343 mL
	5 mM	0.7595 mL	3.7974 mL	7.5947 mL	18.9869 mL
	10 mM	0.3797 mL	1.8987 mL	3.7974 mL	9.4934 mL
	15 mM	0.2532 mL	1.2658 mL	2.5316 mL	6.3290 mL
	20 mM	0.1899 mL	0.9493 mL	1.8987 mL	4.7467 mL
	25 mM	0.1519 mL	0.7595 mL	1.5189 mL	3.7974 mL
	30 mM	0.1266 mL	0.6329 mL	1.2658 mL	3.1645 mL
	40 mM	0.0949 mL	0.4747 mL	0.9493 mL	2.3734 mL
	50 mM	0.0759 mL	0.3797 mL	0.7595 mL	1.8987 mL
	60 mM	0.0633 mL	0.3164 mL	0.6329 mL	1.5822 mL
	80 mM	0.0475 mL	0.2373 mL	0.4747 mL	1.1867 mL
	100 mM	0.0380 mL	0.1899 mL	0.3797 mL	0.9493 mL

Pinacidil monohydrate Related Classifications

Cardiovascular Disease Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinacidil85371-64-8P-1134P1134P 1134Potassium ChannelKcsAInhibitorinhibitorinhibit

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Pinacidil monohydrate (Synonyms: P-1134 monohydrate)

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Other Forms of Pinacidil monohydrate:

Pinacidil monohydrate Related Antibodies

4 Publications Citing Use of MCE Pinacidil monohydrate

Featured Recommendations

•Related Screening Libraries:

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•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Pinacidil monohydrate Related Antibodies

Molarity Calculator

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Complete Stock Solution Preparation Table

Pinacidil monohydrate Related Classifications

Keywords:

Your Recently Viewed Products:

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