Search Result
Results for "
mycotoxin
" in MedChemExpress (MCE) Product Catalog:
17
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-103447
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mycotoxin F2; Toxin F2
|
Estrogen Receptor/ERR
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Others
|
Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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-
-
- HY-103447R
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mycotoxin F2(Standard); Toxin F2 (Standard)
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Estrogen Receptor/ERR
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Others
|
Zearalenone (Standard) is the analytical standard of Zearalenone. This product is intended for research and analytical applications. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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-
-
- HY-103447S1
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mycotoxin F2-13C18; Toxin F2-13C18
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Isotope-Labeled Compounds
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Others
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Zearalenone- 13C18 (Mycotoxin F2- 13C18; Toxin F2- 13C18) is the 13C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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-
-
- HY-W585866
-
|
Fungal
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Cancer
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Alternariol, methyl ether is a common mycotoxin found in spoiled grains and is mutagenic and carcinogenic in vitro .
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-
-
- HY-N6799
-
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Others
|
Infection
|
Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .
|
-
-
- HY-125523
-
-
-
- HY-129208
-
|
Antibiotic
Fungal
|
Infection
|
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
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-
-
- HY-N8267
-
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Others
|
Others
|
Territrem A is a shock-causing mycotoxin isolated from Aspergillus terreus .
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-
-
- HY-125666
-
|
Others
|
Infection
|
Agistatin B, isolated from fungus, is a mycotoxin. Agistatin B inhibits cholesterol synthesis .
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-
-
- HY-117313
-
-
-
- HY-N1320
-
|
Fungal
|
Infection
|
Sambutoxin is a mycotoxin. Sambutoxin can be isolated from wheat culture of Fusarium sambucinum .
|
-
-
- HY-100385
-
Cyclo(L-Pro-L-Trp)
|
PI3K
Bacterial
|
Infection
|
Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC50 of 4.8 μM .
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-
-
- HY-N7780
-
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Others
|
Neurological Disease
|
Aflatrem is a mycotoxin that can be isolated from Aspergillus flavus. Aflatrem has acute neurotoxic effects and can be ued in neurological disease .
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-
-
- HY-N6799R
-
|
Others
|
Infection
|
Neosolaniol (Standard) is the analytical standard of Neosolaniol. This product is intended for research and analytical applications. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .
|
-
-
- HY-N6793
-
|
Microtubule/Tubulin
|
Cancer
|
Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin .
|
-
-
- HY-108385
-
|
Others
|
Cancer
|
Ochratoxin A-D4 is the deuterium labeled Ochratoxin A. Ochratoxin A, a mycotoxin produced by several fungal species, causes nephrotoxicity and renal tumors in a variety of animal species .
|
-
-
- HY-N6684
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Vomitoxin
|
Others
|
Metabolic Disease
|
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .
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-
-
- HY-N6779
-
Patulin
3 Publications Verification
Terinin
|
Bacterial
Apoptosis
Autophagy
Antibiotic
|
Infection
|
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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-
-
- HY-N6779R
-
|
Bacterial
Apoptosis
Autophagy
Antibiotic
|
Infection
|
Patulin (Standard) is the analytical standard of Patulin. This product is intended for research and analytical applications. Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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-
-
- HY-N6685
-
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Others
|
Cardiovascular Disease
|
3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .
|
-
-
- HY-101905
-
-
-
- HY-W018582
-
|
Fungal
|
Infection
|
N-Phenylacrylamide is a special polymer showing high affinity with Ochratoxin A, a colorless and crystalline mycotoxin compound. N-Phenylacrylamide can be applied in the field of mycotoxin extraction, and be used for the security research of agricultural commodities and foods made from cereals and grapes .
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-
-
- HY-N6685R
-
|
Others
|
Cardiovascular Disease
|
3-Acetyldeoxynivalenol (Standard) is the analytical standard of 3-Acetyldeoxynivalenol. This product is intended for research and analytical applications. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .
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-
-
- HY-N6685S1
-
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
3-Acetyldeoxynivalenol- 13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685) . 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .
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-
-
- HY-N6726
-
|
Fungal
|
Infection
Cancer
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Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
|
-
-
- HY-N12908
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Verrucarin H
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Antibiotic
|
Infection
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Roridin H (Verrucarin H) is an antibiotic and can be isolated from Myrothecium verrucaria .
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-
-
- HY-125699
-
|
Fungal
|
Infection
|
Ochratoxin C is the ethyl ester analog of ochratoxin A, a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant.
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-
-
- HY-126657
-
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Fungal
|
Infection
|
Fumigaclavine A, a clavine alkaloid, is a Mycotoxin produced by Aspergillus fumigatus. A. fumigatus can be isolated from contaminating moldy silage .
|
-
-
- HY-129384
-
|
Others
|
Cancer
|
Rubratoxin B is a hepatotoxic mycotoxin that can be found in Penicillium rubrum Stoll. Rubratoxin B shows antitumor activity .
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-
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- HY-N6689
-
|
Antibiotic
|
Infection
Cancer
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Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .
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-
-
- HY-N6695
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Aflatoxin R0
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Others
|
Cancer
|
Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp , and is mutagenic and carcinogenic mycotoxin .
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-
-
- HY-122373
-
|
Others
|
Others
|
Coprine is a mycotoxin isolated from Coprinopsis atramentaria. Coprine is an acetaldehyde dehydrogenase inhibitor that causes the buildup of acetaldehyde, causing the alcohol flushing reaction .
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-
-
- HY-N6724
-
Dihydroalterperylenol
|
Others
|
Metabolic Disease
|
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication .
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-
-
- HY-129247
-
|
Others
|
Others
|
Versicolorin A, a precursor of aflatoxin B1 (AFB1), can serve as an early indicator of aflatoxin (AF) contamination, even when AFs themselves are present at undetectable levels .
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-
-
- HY-N6702
-
-
-
- HY-N6741
-
|
Others
|
Infection
Endocrinology
|
β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .
|
-
-
- HY-N6723
-
|
Acyltransferase
|
Infection
|
Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .
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-
-
- HY-N6770
-
(S)-Curvularin
|
NO Synthase
|
Infection
Inflammation/Immunology
|
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM .
|
-
-
- HY-N6710
-
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Estrogen Receptor/ERR
|
Inflammation/Immunology
|
α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER),
α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .
|
-
-
- HY-126730
-
|
Phosphatase
|
Cancer
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Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A) with an IC50 of 170 nM. Rubratoxin A causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts .
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-
-
- HY-N6726R
-
|
Fungal
|
Infection
Cancer
|
Fumonisin B3 (Standard) is the analytical standard of Fumonisin B3. This product is intended for research and analytical applications. Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
|
-
-
- HY-16928
-
Cytochalasin B
Maximum Cited Publications
29 Publications Verification
Phomin
|
Arp2/3 Complex
|
Cancer
|
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.
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-
-
- HY-N2563
-
|
Fungal
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Infection
|
Neocnidilide is an alkylphthalide, which has the activity of inhibiting the growth of mycotoxin-producing fungi. Neocnidilide also has larvicidal activity against D. melanogaster with a LC50 value of 9.9 μmol/mL .
|
-
-
- HY-N6681
-
|
Caspase
Bacterial
Apoptosis
Antibiotic
|
Infection
|
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3 .
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-
-
- HY-N6740
-
|
Apoptosis
|
Metabolic Disease
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Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
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-
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- HY-N6786
-
|
Endogenous Metabolite
|
Cancer
|
Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
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-
-
- HY-N6726S
-
|
Isotope-Labeled Compounds
|
Cancer
|
Fumonisin B3- 13C34 is the 13C labeled Fumonisin B3 (HY-N6726) . Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
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-
-
- HY-N6730
-
Aminopentol
|
Apoptosis
|
Neurological Disease
|
Hydrolyzed Fumonisin B1 (Aminopentol) is the backbone and main hydrolysis product of the mycotoxin Fumonisin B1 (HY-N6719). Hydrolyzed Fumonisin B1 can weakly inhibit ceramide synthase .
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-
-
- HY-N6777
-
|
Caspase
Bacterial
Apoptosis
Antibiotic
|
Infection
Cancer
|
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .
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-
-
- HY-135526
-
Desmethoxyviridiol
|
Others
|
Infection
|
Demethoxyviridiol is a mycotoxin originally isolated from N. hinnuleum. Demethoxyviridiol induces lethality in day-old cockerels (LD50=4.2 mg/kg). Demethoxyviridiol is also an inhibitor of phosphatidylinositol 3-kinase (PI3K).
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-
- HY-N6726S1
-
|
Isotope-Labeled Compounds
|
Others
|
Fumonisin B3-13C34-1 is the isotopic internal standard of Fumonisin B3 (HY-N6726). Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
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-
- HY-121234
-
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
Botryodiplodin is a mycotoxin isolated from Penicillium roqueforti. Botryodiplodin inhibits the growth of some Gram-positive and Gram-negative bacteria and can also induce DNA-protein cross-links in mammalian cells, inhibiting the synthesis of DNA, RNA, and protein .
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-
- HY-N6719
-
|
Acyltransferase
|
Infection
|
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .
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-
- HY-N6725
-
-
- HY-W014118S
-
|
Isotope-Labeled Compounds
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Cancer
|
α-Hexylcinnamaldehyde-d5 is deuterated labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .
|
-
- HY-W040790S
-
|
Isotope-Labeled Compounds
|
Others
|
2,6-Dimethylpyrazine-d6 is deuterated labeled Beauvericin (HY-N6739). Beauvericin is a Fusarium mycotoxin. Beauvericin inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 3 μM in an enzyme assay using rat liver microsomes .
|
-
- HY-N3806
-
|
Acyltransferase
ERK
|
Infection
Cardiovascular Disease
Cancer
|
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .
|
-
- HY-N6741R
-
|
Others
|
Infection
Endocrinology
|
β-Zearalenol (Standard) is the analytical standard of β-Zearalenol. This product is intended for research and analytical applications. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level .
|
-
- HY-N6710S
-
-
- HY-N6678
-
|
Estrogen Receptor/ERR
|
Endocrinology
|
Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
|
-
- HY-N6710R
-
|
Estrogen Receptor/ERR
|
Inflammation/Immunology
|
α-Zearalenol (Standard) is the analytical standard of α-Zearalenol. This product is intended for research and analytical applications. α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .
|
-
- HY-N11678
-
DON-3-β-D-glucoside; Deoxynivalenol 3-glucoside
|
Drug Metabolite
|
Metabolic Disease
|
Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo .
|
-
- HY-N6786R
-
|
Endogenous Metabolite
|
Cancer
|
Ochratoxin B (Standard) is the analytical standard of Ochratoxin B. This product is intended for research and analytical applications. Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
|
-
- HY-N6723S
-
|
Isotope-Labeled Compounds
|
Infection
|
Fumonisin B2- 13C34 is the 13C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .
|
-
- HY-103447S
-
|
Isotope-Labeled Compounds
|
Others
|
(Rac)-Zearalenone-d6 is the deuterium labled Zearalenone (HY-103447). Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
|
-
- HY-129209
-
|
Others
|
Infection
|
Myrotoxin B is a toxin produced by the fungus Myrothecium roridum that can induce necrotic lesions in mulberry leaves. Myrotoxin B can also promote the infection rate of Myrothecium roridum, acting as an infection factor, increasing the ability of the fungus to infect host plants. Myrotoxin B can be used in plant pathology and mycotoxin research .
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-
- HY-N6704
-
|
ERK
Apoptosis
|
Cancer
|
Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes .
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-
- HY-N6786S
-
|
Isotope-Labeled Compounds
|
Cancer
|
Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
|
-
- HY-N6740S
-
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
β-Zearalanol-d4 is a deuterium labeled Beta-Zearalanol (HY-N6740) . Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
|
-
- HY-N6725R
-
|
DNA/RNA Synthesis
Bacterial
Apoptosis
Antibiotic
Endogenous Metabolite
|
Infection
Cancer
|
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
|
-
- HY-N1952S
-
iso-Eugenol-d3
|
Bacterial
Isotope-Labeled Compounds
|
Infection
|
Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
|
-
- HY-126841
-
|
Others
|
Cancer
|
5-Methoxysterigmatocystin is a mycotoxin with cytotoxic and genotoxic properties. 5-Methoxysterigmatocystin exhibits cytotoxicity against cancer cells A549 and HepG2 (IC50 of 5.5 and 0.7 μM), and induces DNA damage. 5-Methoxysterigmatocystin is a photosensitizer, which utilizes the visible to generate singlet oxygen ( 1O2) .
|
-
- HY-N13025
-
Verrucarin L acetate
|
Fungal
|
Infection
|
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum .
|
-
- HY-N6778
-
|
Potassium Channel
Calcium Channel
|
Neurological Disease
|
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity .
|
-
- HY-N6678S
-
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Endocrinology
|
(Rac)-Zearalanone-d6 is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].
|
-
- HY-N6779S
-
Terinin-13C7
|
Isotope-Labeled Compounds
|
Infection
|
Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
|
-
- HY-N6719S
-
|
Isotope-Labeled Compounds
|
Infection
|
Fumonisin B1- 13C34 is the 13C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .
|
-
- HY-N1944S
-
|
Fungal
Endogenous Metabolite
Bacterial
Parasite
Isotope-Labeled Compounds
|
Cancer
|
Nerolidol-d4 is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor .
|
-
- HY-N6678R
-
|
Estrogen Receptor/ERR
|
Endocrinology
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Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
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- HY-107426
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Muconomycin A
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Apoptosis
Reactive Oxygen Species
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Cancer
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Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 .
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- HY-N6720
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Endogenous Metabolite
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Metabolic Disease
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T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t1/2λz), Peak plasma concentrations (Cmax) and Tmax values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .
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- HY-N3807
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Acyltransferase
ERK
NF-κB
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Infection
Cardiovascular Disease
Cancer
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Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .
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- HY-N6715
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Influenza Virus
Bacterial
Enterovirus
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Infection
Cancer
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Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor that can act as a potential herbicide. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid induces fungal poisoning in mice. Tenuazonic acid has an inhibitory effect on skin cancer .
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- HY-N6714
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Topoisomerase
Androgen Receptor
Estrogen Receptor/ERR
Apoptosis
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Infection
Cancer
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Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .
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- HY-N6715R
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Influenza Virus
Bacterial
Enterovirus
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Infection
Cancer
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Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor that can act as a potential herbicide. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid induces fungal poisoning in mice. Tenuazonic acid has an inhibitory effect on skin cancer .
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- HY-N7432
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Antibiotic
Bacterial
Fungal
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Infection
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DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .
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- HY-N6727
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Aspergillin
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Apoptosis
PKA
NF-κB
Bacterial
Fungal
Antibiotic
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Infection
Inflammation/Immunology
Cancer
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Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .
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- HY-N6746
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NSC 186
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Bacterial
Fungal
Endogenous Metabolite
Apoptosis
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Infection
Neurological Disease
Cancer
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Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
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- HY-N6746S1
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NSC 186-13C13
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Isotope-Labeled Compounds
Apoptosis
Bacterial
Autophagy
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Infection
Neurological Disease
Cancer
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Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
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- HY-N8501
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Others
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Infection
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Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s=3.94, 0.6, 2.21, 4.55, and 2.21 μg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50=5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 μg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-N6689
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Antibiotic
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Infection
Cancer
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Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities .
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-103447S1
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Zearalenone- 13C18 (Mycotoxin F2- 13C18; Toxin F2- 13C18) is the 13C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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- HY-N6685S1
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3-Acetyldeoxynivalenol- 13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685) . 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .
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- HY-N6726S
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Fumonisin B3- 13C34 is the 13C labeled Fumonisin B3 (HY-N6726) . Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
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- HY-N6726S1
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Fumonisin B3-13C34-1 is the isotopic internal standard of Fumonisin B3 (HY-N6726). Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
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- HY-W014118S
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α-Hexylcinnamaldehyde-d5 is deuterated labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .
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- HY-W040790S
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2,6-Dimethylpyrazine-d6 is deuterated labeled Beauvericin (HY-N6739). Beauvericin is a Fusarium mycotoxin. Beauvericin inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 3 μM in an enzyme assay using rat liver microsomes .
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- HY-N6710S
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α-Zearalenol-d4 is a deuterated labeled α-Zearalenol . α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER),
α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .
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- HY-N6723S
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Fumonisin B2- 13C34 is the 13C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .
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- HY-103447S
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(Rac)-Zearalenone-d6 is the deuterium labled Zearalenone (HY-103447). Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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- HY-N6786S
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Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
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- HY-N6740S
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β-Zearalanol-d4 is a deuterium labeled Beta-Zearalanol (HY-N6740) . Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .
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- HY-N1952S
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Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
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- HY-N6678S
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(Rac)-Zearalanone-d6 is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].
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- HY-N6779S
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Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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- HY-N6719S
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Fumonisin B1- 13C34 is the 13C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .
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- HY-N1944S
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Nerolidol-d4 is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor .
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- HY-N6746S1
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Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
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