Fumonisin B1-¹³C₃₄

Cat. No.: HY-N6719S: FAQs
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Fumonisin B1-¹³C₃₄ is the ¹³C labeled Fumonisin B1 (HY-N6719). Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.

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Fumonisin B1-<sup>13</sup>C<sub>34</sub> Chemical Structure

Fumonisin B1-¹³C₃₄ Chemical Structure

CAS No. : 1217458-62-2

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30 μg (33.08 μM * 1.2 mL in Acetonitrile)	USD 1100	Ask For Quote & Lead Time

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Other Forms of Fumonisin B1-¹³C₃₄:

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Purity & Documentation
References
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Description	Fumonisin B1-¹³C₃₄ is the ¹³C labeled Fumonisin B1 (HY-N6719)^[1]. Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin^[2]^[3].
IC₅₀ & Target	Sphingosine N-acyltransferase^[2]
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Fumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells^[2]. Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Fumonisin B1-¹³C₃₄ Related Antibodies
Molecular Weight	755.58
Formula	¹³C₃₄H₅₉NO₁₅
CAS No.	1217458-62-2
Unlabeled CAS	116355-83-0
SMILES	O[13C]([13CH2][13C@@H]([13C](O)=O)[13CH2][13C](O[13C@@H]([13CH2][13C@@H]([13CH3])[13CH2][13C@H](O)[13CH2][13CH2][13CH2][13CH2][13C@@H](O)[13CH2][13C@H](O)[13C@@H](N)[13CH3])[13C@@H]([13C@H]([13CH3])[13CH2][13CH2][13CH2][13CH3])O[13C]([13CH2][13C@H]([13C](O)=O)[13CH2][13C](O)=O)=O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (276 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220. [Content Brief] [2]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. [Content Brief] [3]. Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7(6):1970-6. [Content Brief]