Moniliformin sodium salt

Name: Moniliformin sodium salt
Brand: MedChemExpress
SKU: HY-101905
Rating: 4.5 (1 reviews)

Cat. No.: HY-101905 Purity: 99.50%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Moniliformin sodium salt is a potent mycotoxin isolate from Fusarium moniliforme.

For research use only. We do not sell to patients.

Moniliformin sodium salt Chemical Structure

CAS No. : 71376-34-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 396	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 396	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 570	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

Moniliformin sodium salt is a potent mycotoxin isolate from Fusarium moniliforme.

In Vitro

Fusarium moniliforme NRRL 6322 produces about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. Several strains of Fusarium moniliforme produce in laboratory culture more than 800 mg of moniliformin per kg of growth substrate^[1]. Monocytes-derived macrophages exposed to moniliformin during the differentiation process present a decrease of endocytosis ability, and a decrease of CD71 and HLA-DR expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Moniliformin is less toxic to mice, with an LD₅₀ of 20.9 mg per kg for the females and 29.1 mg per kg of body weight for the males. As in the case of the chicks, mice surviving the toxin demonstrated no ill effects; the mice or chicks that died became recumbent in 4 to 6 h after treatment and died within 24 h. In 4-day-old chicken embryos, a sharp LD₅₀ of 2.8 μg per embryo is obtained with no overt gross teratogenic effects in the survivors^[1]. Rats treated with the highest dose of moniliformin show decreased activity followed by acute heart failure and death. The rats of the lower doses (<9mg/kg b.w.) show no signs of toxicity. The daily intake of moniliformin strongly reduces the phagocytic activity of neutrophils in all dose groups. The decrease continued in the satellite group during the follow-up period, indicating a severe impact on the immune system and a LOAEL value of 3mg/kg b.w. for moniliformin. Moniliformin is rapidly excreted into urine, ranging between 20.2 and 31.5% daily and shows no signs of accumulation. The concentration of moniliformin in faeces is less than 2%, which suggests efficient absorption from the gastrointestinal tract^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

120.04

Formula

C₄HNaO₃

CAS No.

71376-34-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C(O[Na])=C1)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Fusarium moniliforme

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (833.06 mM; Need ultrasonic)

DMSO : ≥ 45 mg/mL (374.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.3306 mL	41.6528 mL	83.3056 mL
5 mM	1.6661 mL	8.3306 mL	16.6611 mL
10 mM	0.8331 mL	4.1653 mL	8.3306 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (277.66 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.50%

Select Batch:

Data Sheet (276 KB) SDS (420 KB)

COA (249 KB) RP-HPLC (259 KB)

Handling Instructions (2659 KB)

References

[1]. Burmeister HR, et al. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Appl Environ Microbiol. 1979 Jan;37(1):11-3. [Content Brief]

[2]. Ficheux AS, et al. Effects of beauvericin, enniatin b and moniliformin on human dendritic cells and macrophages: an in vitro study. Toxicon. 2013 Sep;71:1-10. [Content Brief]

[3]. Jonsson M, et al. Repeated dose 28-day oral toxicity study of moniliformin in rats. Toxicol Lett. 2015 Feb 17;233(1):38-44. [Content Brief]

Animal Administration
^[1]^[3]

Rats: Moniliformin is prepared in water. In this experiment, 5 dose groups (3, 6, 9, 12 and 15 mg/kg moniliformin b.w.) of test animals are exposed to moniliformin for 28 days. Each group consists of 5 male Sprague-Dawley rats. The dose groups are determined based on our acute toxicity study of MON in rats. In addition, a control group administered with filtered tap water and two satellite groups (dosed 12 and 15 mg/kg b.w. moniliformin) are used. The two satellite groups are kept alive for an additional 14 days without treatment to detect possible delayed toxic effects and to follow up recovery^[3].

Mice: Sterile aqueous solutions of moniliformin are injected intraperitoneally (0.2 mL) into five female and five male white mice, weighing about 25 g each, at concentrations equivalent to 0, 20, 25, 30, and 35 mg per kg of body weight. The mice are observed over a 4-day period, and LD₅₀ values are determined^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Burmeister HR, et al. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Appl Environ Microbiol. 1979 Jan;37(1):11-3. [Content Brief]

[2]. Ficheux AS, et al. Effects of beauvericin, enniatin b and moniliformin on human dendritic cells and macrophages: an in vitro study. Toxicon. 2013 Sep;71:1-10. [Content Brief]

[3]. Jonsson M, et al. Repeated dose 28-day oral toxicity study of moniliformin in rats. Toxicol Lett. 2015 Feb 17;233(1):38-44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	8.3306 mL	41.6528 mL	83.3056 mL	208.2639 mL
	5 mM	1.6661 mL	8.3306 mL	16.6611 mL	41.6528 mL
	10 mM	0.8331 mL	4.1653 mL	8.3306 mL	20.8264 mL
	15 mM	0.5554 mL	2.7769 mL	5.5537 mL	13.8843 mL
	20 mM	0.4165 mL	2.0826 mL	4.1653 mL	10.4132 mL
	25 mM	0.3332 mL	1.6661 mL	3.3322 mL	8.3306 mL
	30 mM	0.2777 mL	1.3884 mL	2.7769 mL	6.9421 mL
	40 mM	0.2083 mL	1.0413 mL	2.0826 mL	5.2066 mL
	50 mM	0.1666 mL	0.8331 mL	1.6661 mL	4.1653 mL
	60 mM	0.1388 mL	0.6942 mL	1.3884 mL	3.4711 mL
	80 mM	0.1041 mL	0.5207 mL	1.0413 mL	2.6033 mL
	100 mM	0.0833 mL	0.4165 mL	0.8331 mL	2.0826 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.