Citrinin-¹³C₁₃  (Synonyms: NSC 186-¹³C₁₃₎

Citrinin-¹³C₁₃ (NSC 186-¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin shows significant antitumor effects in a mouse model of breast cancer induced by DMBA (HY-W011845). Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. In addition, Citrinin has antibacterial and neuroprotective activities^{[1][2][3][4][5]}.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

263.15

¹³C₁₃H₁₄O₅

518-75-2

O=[13C]1[13C]([13CH3])=[13C]2[13C@@H]([13CH3])[13C@H]([13CH3])O[13CH]=[13C]2[13C](O)=[13C]1[13C](O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220.  [Content Brief]

  [2]. de Oliveira Filho JWG, et al, A comprehensive review on biological properties of citrinin. Food Chem Toxicol. 2017 Dec;110:130-141.  [Content Brief]

  [3]. Čulig B, et al. PRESENCE OF CITRININ IN GRAINS AND ITS POSSIBLE HEALTH EFFECTS. Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):22-30  [Content Brief]

  [4]. Islam MR, et al. Immune modulatory effects of the foodborne contaminant citrinin in mice. Food Chem Toxicol. 2012 Oct;50(10):3537-47.  [Content Brief]

  [5]. de Oliveira Filho JWG, et al. Citrinin against breast cancer: A cytogenotoxicological study. Phytother Res. 2021 Jan;35(1):504-516.  [Content Brief]