Curvularin (Synonyms: (S)-Curvularin)

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Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC₅₀ of 9.5 µM.

For research use only. We do not sell to patients.

Curvularin Chemical Structure

CAS No. : 10140-70-2

Size		Stock
10 mg		Get quote	Estimated Time of Arrival: December 31
25 mg		Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
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Description

Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC₅₀ of 9.5 µM^[1]^[2].

IC₅₀ & Target

iNOS

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	34.2 μM Compound: (S)-Curvularin	Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after	[PMID: 25537529]
HepG2	IC₅₀	86.4 μM Compound: (S)-Curvularin	Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay	[PMID: 25537529]

Molecular Weight

292.33

Formula

C₁₆H₂₀O₅

CAS No.

10140-70-2

SMILES

O=C(O[C@@H](C)CCCCC1)CC2=CC(O)=CC(O)=C2C1=O

Structure Classification

Initial Source

Microorganisms

fungus Eupenicillium sp

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. [Content Brief]

[2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91. [Content Brief]

Curvularin Related Classifications

Inflammation/Immunology Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Curvularin10140-70-2(S)-CurvularinNO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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