2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Phomopsin A

Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin.

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Phomopsin A Chemical Structure

Phomopsin A Chemical Structure

CAS No. : 64925-80-0

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Description

Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1].

Molecular Weight

789.23

Formula

C36H45ClN6O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](N1)[C@](C)(OC2=CC([C@H](O)[C@H](NC)C(N[C@@H](C(C)=C)C1=O)=O)=CC(Cl)=C2O)CC)N3[C@@H](C=CC3)C(N/C(C(N/C(C(O)=O)=C/C(O)=O)=O)=C(C)/CC)=O
Structure Classification
Initial Source

Phomopsis leptostomiformis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (12.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2671 mL 6.3353 mL 12.6706 mL
5 mM 0.2534 mL 1.2671 mL 2.5341 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2671 mL 6.3353 mL 12.6706 mL 31.6764 mL
5 mM 0.2534 mL 1.2671 mL 2.5341 mL 6.3353 mL
10 mM 0.1267 mL 0.6335 mL 1.2671 mL 3.1676 mL
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Phomopsin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phomopsin A64925-80-0Microtubule/TubulinCyclichexapeptidemycotoxinPhomopsisleptostomiformisradiolabeledvincristinetubulinInhibitorinhibitorinhibit

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