Enniatin A

Cat. No.: HY-N6702: FAQs
Data Sheet Handling Instructions

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Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes.

For research use only. We do not sell to patients.

Enniatin A Chemical Structure

CAS No. : 2503-13-1

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ACAT1 ACAT2 MGAT2 ACAT

Biological Activity
Purity & Documentation
References
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Description

Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes^[1].

IC₅₀ & Target^[1]

ACAT

In Vitro

Enniatin A exhibits cytotoxic effects in HeLa cell lines with IC₅₀s of 1.15 μM concentration for 24 h and 0.57 μM concentration for 48 h^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

681.90

Formula

C₃₆H₆₃N₃O₉

CAS No.

2503-13-1

SMILES

CC[C@@H]([C@]1([H])N(C([C@H](OC(C(N(C([C@@H](C(C)C)OC([C@@]([C@@H](C)CC)([H])N(C)C([C@](C(C)C)([H])OC1=O)=O)=O)=O)C)[C@@H](C)CC)=O)C(C)C)=O)C)C

Structure Classification

Initial Source

Microorganisms

Fusarium sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32. [Content Brief]

[2]. Mamur S, et al. Assessment of cytotoxic and genotoxic effects of enniatin-A in vitro. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Aug;35(8):1633-1644. [Content Brief]

Enniatin A Related Classifications

Infection Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enniatin A2503-13-1AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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