3-Acetyldeoxynivalenol-¹³C₁₇ 

3-Acetyldeoxynivalenol-¹³C₁₇ is the ¹³C labeled 3-Acetyldeoxynivalenol (HY-N6685)^[1]. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative^[2], is a blood-brain barrier (BBB) permeable mycotoxin^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

355.23

¹³C₁₇H₂₂O₇

1217476-81-7

50722-38-8

Liquid

Colorless to light yellow

[13CH3][13C@]12[13C@@]3([13C@@]([H])([13C@H](O[13C]([13CH3])=O)[13CH2]2)O[13C@]4([13C@]1([13CH2]O)[13C@H](O)[13C]([13C]([13CH3])=[13CH]4)=O)[H])[13CH2]O3

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, protect from light, 2 years

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220.  [Content Brief]

  [2]. Kadota T, et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenolon intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol In Vitro. 2013 Sep;27(6):1888-95.  [Content Brief]

  [3]. Behrens M, et al. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One. 2015 Nov 23;10(11):e0143640.  [Content Brief]