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Results for "

orphan disease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROR (6) Cannabinoid Receptor (1) Endogenous Metabolite (1) GPR109A (1) GPR55 (1) LIM Kinase (LIMK) (1) Neuropeptide Y Receptor (1) p38 MAPK (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Targets Recommended: Orphan Receptor ROR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151539

TH470	LIM Kinase (LIMK)	Neurological Disease
TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC₅₀=9.8 nM; LIMK2 IC₅₀=13 nM), and can be used in orphan disease research .

HY-107580

GPR109 receptor agonist-1	GPR109A	Cardiovascular Disease Metabolic Disease
GPR109 receptor agonist-1 (Compound 3a) is a highly selective agonist of the human orphan G-protein-coupled receptor GPR109b, with the pEC₅₀ of 6.4. GPR109 receptor agonist-1 can be used for the research of cardio-metabolic diseases .

HY-132810

Bevurogant BI 730357	ROR	Inflammation/Immunology
Bevurogant (BI 730357) is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases .

HY-111323

ASN06917370	ROR	Neurological Disease
ASN06917370 is a former orphan receptor GPR17 ligand for the study of neurodegenerative diseases. ASN06917370 has an EC₅₀ of 268 pM in [35S]GTPyS experiments .

HY-P1438

Neuropeptide S(Rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease .

HY-128128

ASN04421891	Others	Neurological Disease
ASN04421891 is a potent GPR17 receptor modulator, with an EC₅₀ of 3.67 nM in [35S]GTPγS binding assay. ASN04421891 can be used for neurodegenerative diseases research .

HY-120785

SR1555	ROR	Inflammation/Immunology
SR1555 is a specific *retinoic acid receptor-related orphan* nuclear receptor γ (RORγ) inverse agonist with an IC₅₀** value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases .

HY-113342

7-Ketocholesterol 1 Publications Verification	Endogenous Metabolite p38 MAPK	Cardiovascular Disease Metabolic Disease
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-142936

RORγt modulator 3	ROR	Neurological Disease Inflammation/Immunology Cancer
RORγt modulator 3 (Compound 23) is a modulator of retinoid-related orphan receptor γt (RORγt). RORγt modulator 3 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer .

HY-142935

RORγt modulator 2	ROR	Neurological Disease Inflammation/Immunology Cancer
RORγt modulator 2 (Compound 21) is a modulator of retinoid-related orphan receptor γt (RORγt) with the IC₅₀ of <50 nM. RORγt modulator 2 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer .

HY-120785A

SR1555 hydrochloride	ROR	Inflammation/Immunology
SR1555 hydrochloride is the hydrochloride salt form of SR1555 (HY-120785). SR1555 hydrochloride is an inverse agonist for *retinoic acid receptor-related orphan* nuclear receptor γ (RORγ) with an IC₅₀** of 1 μM. SR1555 hydrochloride inhibits the development and function of pro-inflammatory TH17 cell, increases the frequency of anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride can be used for research about autoimmune diseases .

HY-125111

PSB-SB-487	GPR55 Cannabinoid Receptor	Neurological Disease Metabolic Disease Cancer
PSB-SB-487 is a potent GPR55 antagonist and CB₂ agonist with an IC₅₀ value of 0.113 µM for GPR55, and a K_i value of 0.292 µM for human CB₂. PSB-SB-487 can be used for researching diabetes, Parkinson’s disease, neuropathic pain, and cancer .

Cat. No.	Product Name

HY-L097

Animal Disease Model Inducer Library	51 compounds
Animal disease models are used in a variety of settings in basic research, such as studies on mechanisms of disease progression and evaluation new drugs. Animal models can be broadly classified into five categories: 1) experimental, 2) spontaneous, 3) negative, 4) orphan, 5) genetically engineered. Experimental models, which are induced artificially in the laboratory, are most common. Some small molecular compounds are usually used as inducers for animal models, such as Ceruletide for inflammatory model, Azoxymethane for tumor model. These inducers are useful tool in building animal models. MCE offers a unique collection of 51 animal model inducers, involving inflammatory model, tumor model, nervous disease model, etc. MCE Animal Disease Model library is a powerful tool for the establishment of animal disease models.

Animal Disease Model Inducer Library

51 compounds

Animal disease models are used in a variety of settings in basic research, such as studies on mechanisms of disease progression and evaluation new drugs. Animal models can be broadly classified into five categories: 1) experimental, 2) spontaneous, 3) negative, 4) orphan, 5) genetically engineered. Experimental models, which are induced artificially in the laboratory, are most common. Some small molecular compounds are usually used as inducers for animal models, such as Ceruletide for inflammatory model, Azoxymethane for tumor model. These inducers are useful tool in building animal models.

MCE offers a unique collection of 51 animal model inducers, involving inflammatory model, tumor model, nervous disease model, etc. MCE Animal Disease Model library is a powerful tool for the establishment of animal disease models.

HY-L102

Rare Diseases Drug Library	1,811 compounds
Rare diseases are an important public-health issue and a challenge for the medical community. Most rare diseases are genetic disorders, which are often severely disabling, substantially affect life expectancy, and impair physical and mental abilities. Currently, there are about 7,000 identified rare diseases, together affecting 10% of the population. However, fewer than 6% of all rare diseases have an approved treatment option, highlighting their tremendous unmet needs in drug development. The process of repurposing drugs for new indications, compared with the development of novel orphan drugs, is a time-saving and cost-efficient method resulting in higher success rates, which can therefore drastically reduce the risk of drug development for rare diseases. MCE carefully collects a unique of 1,811 compounds studied in preclinical, clinical trials or approved used in rare diseases treatment. MCE rare diseases drug library is a useful tool for the research of rare diseases. All compounds can provide corresponding indications for rare diseases.

Rare Diseases Drug Library

1,811 compounds

Rare diseases are an important public-health issue and a challenge for the medical community. Most rare diseases are genetic disorders, which are often severely disabling, substantially affect life expectancy, and impair physical and mental abilities. Currently, there are about 7,000 identified rare diseases, together affecting 10% of the population. However, fewer than 6% of all rare diseases have an approved treatment option, highlighting their tremendous unmet needs in drug development. The process of repurposing drugs for new indications, compared with the development of novel orphan drugs, is a time-saving and cost-efficient method resulting in higher success rates, which can therefore drastically reduce the risk of drug development for rare diseases.

MCE carefully collects a unique of 1,811 compounds studied in preclinical, clinical trials or approved used in rare diseases treatment. MCE rare diseases drug library is a useful tool for the research of rare diseases. All compounds can provide corresponding indications for rare diseases.

Cat. No.	Product Name	Target	Research Area

HY-P1438

Neuropeptide S(Rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113342

7-Ketocholesterol 1 Publications Verification	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite p38 MAPK
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

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