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prostaglandin E1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Prostaglandin Receptor (21) 15-PGDH (1) Apoptosis (1) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (13) Fluorescent Dye (1) Isotope-Labeled Compounds (4) P2Y Receptor (2) Phosphodiesterase (PDE) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (10) Endocrinology (11) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Prostaglandin Receptor PGE synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0131

Prostaglandin E1 Maximum Cited Publications 11 Publications Verification Alprostadil; PGE1	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-114942

Prostaglandin E1 ethyl ester prostaglandin E1 Et ester; PGE1-EE	Prostaglandin Receptor	Cardiovascular Disease
Prostaglandin E1 ethyl ester (Prostaglandin E1 Et ester) is the esterified form of Prostaglandin E1 (PGE1; HY-B0131). Prostaglandin E1 (Alprostadil) is a prostaglandin receptor ligand that induces vasodilation and inhibits platelet aggregation .

HY-138206

Prostaglandin E1 isopropyl ester PGE1 isopropyl ester	Prostaglandin Receptor	Cardiovascular Disease
Prostaglandin E1 isopropyl ester is an isopropyl ester form of prostaglandin E1 (HY-B0131). Prostaglandin E1 isopropyl ester exhibits a faster penetration flux than prostaglandin E1 .

HY-137133

Prostaglandin E1 alcohol	Prostaglandin Receptor	Inflammation/Immunology Cancer
Prostaglandin E1 alcohol (compound 89) is a prostaglandin analog .

HY-137567

Prostaglandin E1 ethanolamide	Prostaglandin Receptor	Cancer
Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth .

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-B0131S

Prostaglandin E1-d4	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

HY-B0131S2

Prostaglandin E1-d9 Alprostadil-d₉; PGE1-d₉	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-137117

15-keto-PGE1 15-keto prostaglandin E1	Drug Metabolite	Others
15-keto-PGE1 is an inactive Prostaglandin E1 (PGE1) metabolite. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation .

HY-168397

*tetranor-Prostaglandin* E1**	Prostaglandin Receptor	Endocrinology
tetranor-Prostaglandin E1 is metabolite of Prostaglandin E1 (HY-B0131) and Prostaglandin E2 (HY-101952) that is formed by β-oxidation .

HY-130226

11-epi-PGE1 11β-prostaglandin E1	Endogenous Metabolite Prostaglandin Receptor	Cardiovascular Disease Endocrinology Cancer
11-epi-PGE1 (11β-Prostaglandin E1) is a less potent isomer of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand .

HY-128043

*11-Deoxy prostaglandin* E1** AY-23578; Doproston B; 11-Deoxy-PGE1	Prostaglandin Receptor	Inflammation/Immunology
11-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs .

HY-116096

15-epi-PGE1 15(R)-prostaglandin E1; 15-Epiprostaglandin E1	15-PGDH	Others
15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1) is a stereoisomer of PGE1 (HY-B0131) but with less biological activity . 15-epi-PGE1 is a non-competitive inhibitor for human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) with an IC₅₀ of 170 μM .

HY-19167

Ecraprost AS 013; Lipo-pro-prostaglandin E1	Prostaglandin Receptor	Inflammation/Immunology
Ecraprost is a prodrug of prostaglandin E1. Ecraprost inhibits platelet adhesion, macrophage infiltration and proliferating cell nuclear antigen positive cell expression on the injured arterial walls .

HY-118094

*8-iso Prostaglandin* E1** Ovinonic acid; 8-iso-PGE1	Prostaglandin Receptor	Cardiovascular Disease
8-iso Prostaglandin E1 (Ovinonic acid; 8-iso-PGE1) is a spasmodic agent in canine pulmonary veins and can also cause vasodilation .

HY-114986

6-Keto-PGE1 1 Publications Verification 6-keto-prostaglandin E1	Endogenous Metabolite	Cardiovascular Disease
6-Keto-PGE1 (6-keto-Prostaglandin E1) is a bioactive derivative of PGE1. 6-Keto-PGE1 has hemodynamic and cytoprotective effects in traumatic shock .

HY-157925

Bicyclo-PGE1 Bicyclo prostaglandin E1	Endogenous Metabolite	Others
Bicyclo-PGE1 (Bicyclo Prostaglandin E1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo-PGE1 can be used to estimate the biosynthesis and metabolism of PGE1 in vivo .

HY-137574

*19(R)-Hydroxy prostaglandin* E1** 19(R)-Hydroxy PGE1	Prostaglandin Receptor	Others
19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations .

HY-137584

*1a,1b-Dihomo prostaglandin* E1** 1a,1b-Dihomo PGE1	Prostaglandin Receptor	Endocrinology
1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is a class of prostaglandin compound .

HY-120665

Prostaglandin B1 PGB1	Prostaglandin Receptor	Endocrinology
Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand .

HY-114862

*13,14-dihydro-15(R)-Prostaglandin* E1** 13,14-dihydro-15(R)-PGE1	Endogenous Metabolite	Others
13,14-dihydro-15(R)-Prostaglandin E1 (13,14-dihydro-15(R)- PGE1) is an analog of 13,14-dihydro- PGE1 which has the hydroxyl group at C-15 in the unnatural R configuration .

HY-113053

Prostaglandin A1	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Prostaglandin A1 is a dehydration derivate of Prostaglandin E1. Prostaglandin A1 exhibits inhibitory activities against tumor growth, inflammation, virus replication, platelet aggregation and excitotoxin-induced neurons apoptosis .

HY-139968S

*13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin* E1-d4**	Isotope-Labeled Compounds	Others
13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d₄ is the deuterium labeled 13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1[1].

HY-105126

Rioprostil TR4698	Prostaglandin Receptor	Others
Rioprostil (TR4698) is an orally effective analogue of prostaglandin E1, possessing potent antisecretory and anti-gastric lesion properties. Rioprostil can be utilized in mucosal protection research .

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Endogenous Metabolite	Inflammation/Immunology
Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects .

HY-157976

Dinorprostaglandin E1 dinor-PGE1	Endogenous Metabolite Prostaglandin Receptor	Others
Dinorprostaglandin E1 (dinor-PGE1) is the hepatocyte metabolite of prostaglandin E1 and prostaglandin E. Prostaglandin E1 and prostaglandin E inhibit glucagon, epinephrine, isoproterenol (beta-adrenergic agonist), or epinephrine-stimulated glycogenolysis when co-treated with Isoproterenol (HY-B0468) .

HY-106534

Gemeprost Preglandin; SC-37681	Prostaglandin Receptor	Endocrinology
Gemeprost (Preglandin), a Prostaglandin E1 (HY-B0131) analogue, is a potent antiprogestogen drug. Gemeprost has the potential for second trimester abortion research .

HY-113113S

13,14-Dihydro PGE1-d4 13,14-Dihydroprostaglandin E1-d₄; PGE0-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
13,14-Dihydro PGE1-d₄ (13,14-Dihydroprostaglandin E1-d₄) is deuterium labeled 13,14-Dihydro PGE1. 13,14-Dihydro PGE₁ is a metabolite of PGE₁ (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID₅₀ = 10.8 ng/mL platelet rich plasma) .

HY-113113

13,14-Dihydro PGE1 13,14-Dihydroprostaglandin E1	Endogenous Metabolite	Metabolic Disease
13,14-Dihydro PGE₁ is a metabolite of PGE₁ (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID₅₀ = 10.8 ng/mL platelet rich plasma) .

HY-105912

ONO 1082	Drug Derivative	Endocrinology
ONO 1082 is a Prostaglandin E1 (PGE1) (HY-B0131) derivative and increases cAMP level in hepatocytes. ONO 1082 competes with the action of the cholestatic factor through the increase in the cAMP level .

HY-118189

Misoprostol acid	Prostaglandin Receptor	Inflammation/Immunology
Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers . Misoprostol is an oral agent used to induce labor .

HY-118189S

Misoprostol acid-d5	Isotope-Labeled Compounds Prostaglandin Receptor	Inflammation/Immunology
Misoprostol acid-d₅ is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].

HY-124371

Amentoflavone hexaacetate	Phosphodiesterase (PDE)	Cardiovascular Disease
Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects .

HY-108648

2-MeS-ADP trisodium 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium	P2Y Receptor	Neurological Disease
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC₅₀s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC₅₀s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .

HY-108648A

2-MeSADP 2-Methylthioadenosine diphosphate; 2-Methylthio-ADP	P2Y Receptor	Neurological Disease
2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent purinergic P2Y receptors agonist, with EC₅₀s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-MeSADP has pEC₅₀s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-MeSADP induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .

HY-P4406

*Abz-AGLA-Nba*	Fluorescent Dye	Others
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .

Cat. No.	Product Name	Target	Research Area

HY-P4406

*Abz-AGLA-Nba*	Fluorescent Dye	Others
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0131

Prostaglandin E1 10+ Cited Publications Alprostadil; PGE1	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects .

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-120665

Prostaglandin B1 PGB1	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Prostaglandin Receptor
Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand .

HY-113053

Prostaglandin A1	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite Apoptosis
Prostaglandin A1 is a dehydration derivate of Prostaglandin E1. Prostaglandin A1 exhibits inhibitory activities against tumor growth, inflammation, virus replication, platelet aggregation and excitotoxin-induced neurons apoptosis .

HY-124371

Amentoflavone hexaacetate	Structural Classification Flavonoids Viburnaceae Source classification Plants Biflavones Viburnum lantana L.	Phosphodiesterase (PDE)
Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects .

Cat. No.	Product Name	Chemical Structure

HY-B0131S

Prostaglandin E1-d4

Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

HY-B0131S2

Prostaglandin E1-d9
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-139968S

*13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin* E1-d4**
13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d₄ is the deuterium labeled 13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1[1].

HY-113113S

13,14-Dihydro PGE1-d4
13,14-Dihydro PGE1-d₄ (13,14-Dihydroprostaglandin E1-d₄) is deuterium labeled 13,14-Dihydro PGE1. 13,14-Dihydro PGE₁ is a metabolite of PGE₁ (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID₅₀ = 10.8 ng/mL platelet rich plasma) .

HY-118189S

Misoprostol acid-d5

Misoprostol acid-d₅ is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].

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prostaglandin E1

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