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Results for "

tryptophan

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tryptophan Hydroxylase (20) 5-HT Receptor (5) Amino Acid Derivatives (7) Angiotensin-converting Enzyme (ACE) (4) Antibiotic (2) Apoptosis (11) Aryl Hydrocarbon Receptor (8) Autophagy (2) Bacterial (7) Biochemical Assay Reagents (6) Caspase (1) CXCR (4) DNA Methyltransferase (1) Endogenous Metabolite (67) Ferroptosis (1) Fluorescent Dye (1) Glucocorticoid Receptor (2) Glucosidase (1) GPR35 (4) HCV (2) iGluR (7) Indoleamine 2,3-Dioxygenase (IDO) (7) Interleukin Related (1) Isotope-Labeled Compounds (16) mGluR (2) Mitochondrial Metabolism (1) Necroptosis (2) Neurokinin Receptor (1) P-glycoprotein (1) STAT (3) Tau Protein (1) VEGFR (2)
By Research Areas:	Cancer (38) Cardiovascular Disease (14) Endocrinology (6) Infection (12) Inflammation/Immunology (31) Metabolic Disease (42) Neurological Disease (42)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Solubilizing Agents (1) Freeze-drying Protective Agents (1)

151

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Tryptophan Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0623R

*L-Tryptophan* (standard)** 4 Publications Verification tryptophan (standard); tryptophane (standard)	Others	Metabolic Disease
L-Tryptophan (standard) is the analytical standard of L-Tryptophan. L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels .

HY-N0623S

*L-Tryptophan-d5* tryptophan-d₅; tryptophane-d₅	Endogenous Metabolite	Metabolic Disease
L-Tryptophan-d₅ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S5

*L-Tryptophan-d8* tryptophan-d₈; tryptophane-d₈	Endogenous Metabolite	Metabolic Disease
L-Tryptophan-d₈ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S9

*L-Tryptophan-d3* tryptophan-d₃; tryptophane-d₃	Endogenous Metabolite	Metabolic Disease
L-Tryptophan-d₃ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S1

*L-Tryptophan-13C* tryptophan-¹³C; tryptophane-¹³C	Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹³C is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S7

*L-Tryptophan-15N* tryptophan-¹⁵N; tryptophane-¹⁵N	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹⁵N is the ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S3

*L-Tryptophan-1-13C* tryptophan-1-¹³C; tryptophane-1-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Tryptophan-1- ¹³C is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S2

*L-Tryptophan-13C11* tryptophan-¹³C₁₁; tryptophane-¹³C₁₁	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹³C₁₁ is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S8

*L-Tryptophan-15N2* tryptophan-¹⁵N₂; tryptophane-¹⁵N₂	Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹⁵N₂ is the ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S6

*L-Tryptophan-15N2,d8* tryptophan-¹⁵N₂,d₈; tryptophane-¹⁵N₂,d₈	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹⁵N₂,d₈ is the deuterium and ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S4

*L-Tryptophan-13C11,15N2* tryptophan-¹³C₁₁,¹⁵N₂; tryptophane-¹³C₁₁,¹⁵N₂	Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹³C₁₁, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-P2876

Tryptophanase	Bacterial	Infection
Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

HY-W050025

6-Chloro-L-tryptophan	Amino Acid Derivatives	Others
6-Chloro-L-tryptophan is a Tryptophan derivative. 6-Chloro-L-tryptophan can be used as a substrate for KtzQ .

HY-138815

(S)-N-(1H-Indole-3-acetyl)tryptophan	Glucosidase	Metabolic Disease
(S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .

HY-W077257

5-Bromo-DL-tryptophan	Endogenous Metabolite	Others
5-Bromo-DL-tryptophan is a natural product which can be obtained from Aspergillus fumigatus .

HY-20897A

5-Bromo-L-tryptophan	Endogenous Metabolite	Others
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

HY-W012480

DL-Tryptophan (±)-tryptophan	Endogenous Metabolite	Metabolic Disease
DL-Tryptophan is an endogenous metabolite.

HY-16724

Indoximod 5+ Cited Publications 1-Methyl-D-tryptophan; NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer .

HY-W012480S

*DL-Tryptophan-d3* (±)-tryptophan-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
DL-Tryptophan-d₃ is the deuterium labeled DL-Tryptophan. DL-Tryptophan is an endogenous metabolite.

HY-W012480S1

*DL-Tryptophan-d8* (±)-tryptophan-d₈	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
DL-Tryptophan-d₈ is the deuterium labeled DL-Tryptophan. DL-Tryptophan is an endogenous metabolite.

HY-W011978R

*N-Acetyl-L-tryptophan* (Standard)**	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-tryptophan (Standard) is the analytical standard of N-Acetyl-L-tryptophan. This product is intended for research and analytical applications. N-Acetyl-L-tryptophan is an endogenous metabolite.

HY-135597

N-Acetyl-5-methyl-L-tryptophan	Others	Others
N-Acetyl-5-methyl-L-tryptophan is a N-Acetyl-L-tryptophan analog.

HY-33228

5-Methyl-DL-tryptophan	Amino Acid Derivatives	Others
5-Methyl-DL-tryptophan is aamino acids and their derivatives.

HY-W142072

6-Methyl-DL-tryptophan	Biochemical Assay Reagents
6-Methyl-DL-tryptophan is a kind of biochemical reagent.

HY-W097167

N-Cbz-DL-tryptophan Z-DL-Trp-OH	Biochemical Assay Reagents	Others
N-Cbz-DL-tryptophan (Z-DL-Trp-OH) is the enantiomer of tryptophan derivative .

HY-126965

Lipid Y	Others	Others
Lipid Y is a potent monosaccharide which contains two bromines per chain. lipid Y binds to a tryptophan residue in a membrane protein and then quenches the fluorescence of the tryptophan residue .

HY-W011978

N-Acetyl-L-tryptophan	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related	Neurological Disease Inflammation/Immunology
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-142127S

*2-(α-D-Mannopyranosyl)-L-tryptophan-d4*	Isotope-Labeled Compounds Antibiotic	Others
2-(α-D-Mannopyranosyl)-L-tryptophan-d₄ is the deuterium labeled 2-(α-D-Mannopyranosyl)-L-tryptophan[1].

HY-128731

5-Methoxy-DL-tryptophan 1 Publications Verification DL-5-MTP	Endogenous Metabolite	Metabolic Disease
5-Methoxy-DL-tryptophan is an endogenous metabolite.

HY-W142073

7-Methyl-DL-tryptophan 7-Methyltryptophan	Amino Acid Derivatives	Infection
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .

HY-146628S

*5-Hydroxy-L-tryptophan-4,6,7-d3*	Isotope-Labeled Compounds	Infection
5-Hydroxy-L-tryptophan-4,6,7-d₃ is the deuterium labeled 5-Hydroxy-L-tryptophan-4,6,7[1].

HY-13642

RG108 5+ Cited Publications N-Phthalyl-L-tryptophan	DNA Methyltransferase	Cancer
RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC₅₀=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences .

HY-W012479

H-D-Trp-OH D-tryptophan	Endogenous Metabolite	Metabolic Disease
H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-33298

LM10	Others	Cancer
LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases .

HY-W142080

α-Methyl-DL-tryptophan α-Methyltryptophan	Amino Acid Derivatives	Others
α-Methyl-DL-tryptophan (α-Methyltryptophan) is atryptophan derivative.

HY-108681

680C91 1 Publications Verification	Others	Neurological Disease Inflammation/Immunology Cancer
680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a K_i of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease .

HY-20899

6-Bromo-L-tryptophan 6BrW	Others	Others
6-Bromo-L-tryptophan (6BrW) is a compound that can be incorporated into recombinant proteins by a specific system in bacterial cells, causing a blue shift in fluorescence emission and absorption maxima.

HY-N12125

Entadamide A	Others	Infection
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

HY-N10270

Verrucofortine	Endogenous Metabolite	Others
Verrucofortine, a fungal metabolite, is an alkaloid derived from tryptophan and leucine .

HY-W012479S

H-D-Trp-OH-d5 D-tryptophan-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
H-D-Trp-OH-d₅ (D-Tryptophan-d₅) is the deuterium labeled H-D-Trp-OH. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-W092533

6-Fluorotryptophan	Tryptophan Hydroxylase	Neurological Disease
6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes .

HY-W166764

5-Nitrotryptophan	Others	Neurological Disease
5-Nitrotryptophan is a Tryptophan derivative. 5-Nitrotryptophan can be used for the study of neurodegenerative diseases .

HY-N0707

(S)-Indoximod 1-Methyl-L-tryptophan; (S)-NLG-8189	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Cancer
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (K_i: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease .

HY-59208

4-Quinolinol Kynurine	Endogenous Metabolite	Neurological Disease Cancer
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-151223

D-Glyceraldehyde 3-phosphate Triose phosphate	Endogenous Metabolite	Metabolic Disease
D-Glyceraldehyde 3-phosphate (Triose phosphate) is a common molecule in living organisms and is an important intermediate in glycolysis and gluconeogenesis, as well as a sugar product of the Calvin cycle. D-Glyceraldehyde 3-phosphate is involved in the biosynthesis of tryptophan and thiamin .

HY-133897

(Rac)-Indoximod 1 Publications Verification 1-Methyl-DL-tryptophan; (Rac)-NLG-8189	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Inflammation/Immunology Cancer
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes .

HY-77839

Cortodoxone 2 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-134426

DL-β-Hydroxybutyryl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase .

HY-23460

p-Ethynylphenylalanine 1 Publications Verification 4-Ethynyl-L-phenylalanine	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-23460A

p-Ethynylphenylalanine hydrochloride 1 Publications Verification 4-Ethynyl-L-phenylalanine hydrochloride	Tryptophan Hydroxylase	Neurological Disease
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Type

HY-158779

Sulfane sulfur probe 4

SSP4

Fluorescent Dyes/Probes

Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

Cat. No.	Product Name	Type

HY-W008963

Fmoc-D-Trp-OH Nα-Fmoc-D-tryptophan; Fmoc-D-Trp-OH	Biochemical Assay Reagents
Fmoc-D-Trp-OH (Nα-Fmoc-D-tryptophan) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-134426

DL-β-Hydroxybutyryl coenzyme A lithium	Enzyme Substrates
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase .

HY-W016729

4-(Dimethylamino)cinnamaldehyde	Cell Assay Reagents
4-(Dimethylamino)cinnamaldehyde is a reagent used for determining indole products of tryptophan decarboxylase and tryptophanase, and can also be used for quantifying proanthocyanidins in cranberry powder.

HY-W014971

Tryptamine hydrochloride

1 Publications Verification

Biochemical Assay Reagents

Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

HY-Y1968A

Sterile 10 mM Histidine, pH 5.5 buffer

Biochemical Assay Reagents

Sterile 10 mM Histidine, pH 5.5 buffer is a multi-purpose buffer solution with important applications in many fields such as protein purification, vaccine preparation, drug development, cell culture and electrophoresis. Histidine is an amino acid with good buffering capacity. Sterile 10 mM Histidine, pH 5.5 buffer The sterility and specific pH conditions make it ideal for experiments that require precise control of environmental conditions. The histidine in Sterile 10 mM Histidine, pH 5.5 buffer derivatizes photosensitizers that accumulate and increase greatly upon exposure to light. Histidine-derived photosensitizers are also the primary mediators of tryptophan photooxidation .

HY-W142072

6-Methyl-DL-tryptophan	Cell Assay Reagents
6-Methyl-DL-tryptophan is a kind of biochemical reagent.

HY-W127746

Picrolonic acid	Biochemical Assay Reagents
Picrolonic acid is the reagent for the separation of amines as crystalline π-complexes. Pyrrolic acid is an analytical reagent for the determination of calcium, magnesium, lead, strontium and thorium. It is also used for the analysis of alkaloids, tryptophan and phenylalanine.

Cat. No.	Product Name	Target	Research Area

HY-W050025

6-Chloro-L-tryptophan	Amino Acid Derivatives	Others
6-Chloro-L-tryptophan is a Tryptophan derivative. 6-Chloro-L-tryptophan can be used as a substrate for KtzQ .

HY-20897A

5-Bromo-L-tryptophan	Endogenous Metabolite	Others
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

HY-33228

5-Methyl-DL-tryptophan	Amino Acid Derivatives	Others
5-Methyl-DL-tryptophan is aamino acids and their derivatives.

HY-W142080

α-Methyl-DL-tryptophan α-Methyltryptophan	Amino Acid Derivatives	Others
α-Methyl-DL-tryptophan (α-Methyltryptophan) is atryptophan derivative.

HY-138815

(S)-N-(1H-Indole-3-acetyl)tryptophan	Glucosidase	Metabolic Disease
(S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .

HY-W142073

7-Methyl-DL-tryptophan 7-Methyltryptophan	Amino Acid Derivatives	Infection
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .

HY-W142140

N-Methyl-DL-valine N-Methylvaline	Amino Acid Derivatives	Others
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .

HY-P10520

RWmix	Peptides	Others
RWmix is a synthetic cell-penetrating peptide. The secondary amphiphilic nature of RWmix promotes cellular uptake, mainly due to the alternating arrangement of arginine and tryptophan. The presence of tryptophan enhances the anchoring of the peptide to the cell membrane, thereby improving its ability to penetrate the cell membrane. RWmix can be used for gene therapy and siRNA delivery research .

HY-P4276

Arg-Trp	Bacterial	Infection
Arg-Trp is a dipeptide composed of arginine and tryptophan, and analogues of Arg-Trp-octyl ester show antibacterial activity .

HY-P4648

H-Trp-Trp-Trp-OH	Bacterial	Infection
H-Trp-Trp-Trp-OH is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity .

HY-13718

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	VEGFR HCV Endogenous Metabolite	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .

HY-W007223

D-5-Hydroxytryptophan D-5-HTP; 5-Hydroxy-D-tryptophan	5-HT Receptor	Neurological Disease
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range .

HY-P4227A

WRVYEKC(dnp)ALK tetraTFA	Peptides	Metabolic Disease
WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a 5-HT biosynthesis inhibitor. 4-Chloro-L-phenylalanine is also a nonspecific antagonist of both isoforms of tryptophan hydroxylase (TPH1 and TPH2) .

HY-P4716

Boc-D-Trp(For)-OH	Peptides	Inflammation/Immunology
Boc-D-Trp(For)-OH, containing the amino acid tryptophan, is synthesized by the ammonolysis of Boc-protected D-alanine, followed by cyclization to form a dipeptide with ninhydrin. Boc-D-Trp(For)-OH has pharmacological properties, including inhibition of growth hormone release, induction of sleep and antiinflammatory .

HY-P4641

H-Trp-Phe-OH	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice .

HY-P10456

[Leu144,Arg147]-PLP (139-151)	Peptides	Inflammation/Immunology
[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0623

L-Tryptophan 4 Publications Verification tryptophan; tryptophane	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Cancer	Others
L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels .

HY-N0623R

*L-Tryptophan* (standard)** 4 Publications Verification tryptophan (standard); tryptophane (standard)	Structural Classification Alkaloids Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
L-Tryptophan (standard) is the analytical standard of L-Tryptophan. L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels .

HY-20897A

5-Bromo-L-tryptophan	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

HY-W012480

DL-Tryptophan (±)-tryptophan	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DL-Tryptophan is an endogenous metabolite.

HY-W011978

N-Acetyl-L-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-128731

5-Methoxy-DL-tryptophan 1 Publications Verification DL-5-MTP	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Methoxy-DL-tryptophan is an endogenous metabolite.

HY-W012479

H-D-Trp-OH D-tryptophan	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-N12125

Entadamide A	Structural Classification Natural Products Petasites formosanus Kitam. Leguminosae Source classification Plants	Others
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

HY-W077257

5-Bromo-DL-tryptophan	Structural Classification Alkaloids Animals Source classification Indole Alkaloids	Endogenous Metabolite
5-Bromo-DL-tryptophan is a natural product which can be obtained from Aspergillus fumigatus .

HY-W011978R

*N-Acetyl-L-tryptophan* (Standard)**	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
N-Acetyl-L-tryptophan (Standard) is the analytical standard of N-Acetyl-L-tryptophan. This product is intended for research and analytical applications. N-Acetyl-L-tryptophan is an endogenous metabolite.

HY-N10270

Verrucofortine	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Endogenous Metabolite
Verrucofortine, a fungal metabolite, is an alkaloid derived from tryptophan and leucine .

HY-N0707

(S)-Indoximod 1-Methyl-L-tryptophan; (S)-NLG-8189	Structural Classification Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Abrus precatorius Linn. Plants Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO)
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (K_i: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease .

HY-59208

4-Quinolinol Kynurine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Quinoline Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-77839

Cortodoxone 2 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-77839R

Cortodoxone (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-W001171

3-Hydroxyanthranilic acid	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.

HY-113227

Oxoadipic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.

HY-B0863

Glyphosate	Microorganisms Source classification	Apoptosis Autophagy Necroptosis
Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .

HY-104026

L-Kynurenine Maximum Cited Publications 8 Publications Verification	Cardiovascular Disease Structural Classification Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields	Aryl Hydrocarbon Receptor Endogenous Metabolite
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-W011982

Ac-DL-Trp-OH N-Acetyl-DL-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Ac-DL-Trp-OH is an endogenous metabolite.

HY-141466

Crotonyl-CoA	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Crotonyl-CoA is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA is important in the metabolism of fatty acids and amino acids .

HY-113227R

Oxoadipic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite	Endogenous Metabolite
Oxoadipic acid (Standard) is the analytical standard of Oxoadipic acid. This product is intended for research and analytical applications. Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.

HY-40161

Indole-3-carboxylic acid	Alkaloids Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-W013046

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

HY-13718

Oglufanide H-Glu-Trp-OH; L-Glutamyl-L-tryptophan	Cardiovascular Disease Structural Classification Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	VEGFR HCV Endogenous Metabolite
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .

HY-N0122

5-Hydroxytryptophan 1 Publications Verification 5-HTP; DL-5-Hydroxytryptophan	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-W001171R

3-Hydroxyanthranilic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
3-Hydroxyanthranilic acid (Standard) is the analytical standard of 3-Hydroxyanthranilic acid. This product is intended for research and analytical applications. 3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.

HY-162397

Neopetromin	Structural Classification Monophenols Microorganisms Source classification Phenols	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

HY-113099

Indolelactic acid 4 Publications Verification Indole-3-lactic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .

HY-W008820

Glutaric acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-104026R

L-Kynurenine (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Aryl Hydrocarbon Receptor Endogenous Metabolite
L-Kynurenine (Standard) is the analytical standard of L-Kynurenine. This product is intended for research and analytical applications. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-113294

3-Hydroxykynurenine 3-Hydroxy-DL-kynurenine	Structural Classification Monophenols Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
3-Hydroxykynurenine, a?metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .

HY-107512

Kynurenic acid sodium 3 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields	iGluR Apoptosis Endogenous Metabolite CXCR GPR35
Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.

HY-100806

Kynurenic acid 3 Publications Verification Quinurenic acid	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Quinoline Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	iGluR Endogenous Metabolite Apoptosis CXCR GPR35
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.

HY-W028393

Indole-3-pyruvic acid	Structural Classification Alkaloids Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Indole Alkaloids	Endogenous Metabolite Aryl Hydrocarbon Receptor
Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety .

HY-N1436

L-(+)-Abrine L-Abrine; L-N-Methyltryptophan; N-α-Methyl-L-tryptophan	Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Abrus precatorius Linn. Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	Others
L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.

HY-100807

Quinolinic acid 3 Publications Verification	Alkaloids Structural Classification Microorganisms Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite	Endogenous Metabolite iGluR
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction .

HY-143888

AD013	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Angiotensin-converting Enzyme (ACE)
AD013 is a dual inhibitor of cACE/NEP. AD013 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD013 has the potential for providing the potent antihypertensive and cardioprotective benefits .

HY-141465

3-Hydroxybutyryl-CoA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
3-Hydroxybutyryl-CoA is a metabolite which can be found in mouse or E.coli, et al. 3-Hydroxybutyryl-CoA has a 3-hydroxybutanoyl as the S-acyl component, and is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan .

HY-W012479R

H-D-Trp-OH (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
H-D-Trp-OH (Standard) is the analytical standard of H-D-Trp-OH. This product is intended for research and analytical applications. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-100806R

Kynurenic acid (Standard) 3 Publications Verification Quinurenic acid (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Quinoline Alkaloids Endogenous metabolite	iGluR Endogenous Metabolite Apoptosis CXCR GPR35
Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.

HY-40161R

Indole-3-carboxylic acid (Standard)	Alkaloids Structural Classification Human Gut Microbiota Metabolites Source classification Endogenous metabolite Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid (Standard) is the analytical standard of Indole-3-carboxylic acid. This product is intended for research and analytical applications. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-100807R

Quinolinic acid (Standard) 3 Publications Verification	Structural Classification Alkaloids Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite	Endogenous Metabolite iGluR
Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction .

HY-113294R

3-Hydroxykynurenine (Standard) 3-Hydroxy-DL-kynurenine (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite Apoptosis
3-Hydroxykynurenine (Standard) is the analytical standard of 3-Hydroxykynurenine. This product is intended for research and analytical applications. 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .

HY-W015273A

trans-3-Indoleacrylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Ferroptosis
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis

HY-W014502

D-Kynurenine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Aryl Hydrocarbon Receptor Endogenous Metabolite
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR) .

HY-W014502R

D-Kynurenine (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite	Aryl Hydrocarbon Receptor Endogenous Metabolite
D-Kynurenine (Standard) is the analytical standard of D-Kynurenine. This product is intended for research and analytical applications. D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR) .

HY-W008820R

Glutaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I . In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .

Species:	Human (3) E.coli (3)
Tag:	His (5) Tag Free (1)
Source:	Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71098

	Tryptophan Synthase Protein, E.coli (His) tryptophan synthetase; tryptophan synthase	E.coli	E. coli
	The TrpA protein, especially its α subunit, plays a crucial role in catalyzing the aldol cleavage of indole glycerol phosphate to produce indole and glyceraldehyde 3-phosphate. This enzymatic activity highlights the importance of TrpA in the tryptophan biosynthetic pathway, providing an essential component of cellular processes. Tryptophan Synthase Protein, E.coli (His) is a recombinant protein dimer complex containing E. coli-derived Tryptophan Synthase protein, expressed by E. coli , with N-6*His labeled tag. Tryptophan Synthase Protein, E.coli (His), has molecular weight of 28 & 40-50 kDa, respectively.

HY-P73566

	Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) TPH; TPH-1; TPRH; tryptophan 5-hydroxylase 1; tryptophan Hydroxylase 1	Human	E. coli
	The tryptophan hydroxylase 1 (TPH-1) protein is key to serotonin biosynthesis, catalyzing the rate-limiting step: the oxidation of L-tryptophan to 5-hydroxy-L-tryptophan. This enzyme activity is critical for the synthesis of serotonin, a neurotransmitter that affects mood, sleep, and appetite. Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is the recombinant human-derived Tryptophan Hydroxylase 1/TPH-1 protein, expressed by E. coli , with N-His labeled tag. The total length of Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His) is 443 a.a., with molecular weight of ~48 kDa.

HY-P71097

	TrpA Protein, E.coli tryptophan synthase alpha chain; trpA;	E.coli	E. coli
	The TrpA protein, especially its α subunit, plays a crucial role in catalyzing the aldol cleavage of indole glycerol phosphate to produce indole and glyceraldehyde 3-phosphate. This enzymatic activity highlights the importance of TrpA in the tryptophan biosynthetic pathway, providing an essential component of cellular processes. TrpA Protein, E.coli is the recombinant E. coli-derived TrpA protein, expressed by E. coli , with tag free. The total length of TrpA Protein, E.coli is 268 a.a., with molecular weight of ~26 kDa.

HY-P73540

	WARS Protein, Human (sf9, His) tryptophan--tRNA ligase, cytoplasmic; IFP53; TrpRS; WARS1; WARS	Human	Sf9 insect cells
	WARS includes isomer 1, isomer 2, T1-TrpRS and T2-TrpRS, and has aminoacylation activity, except T2-TrpRS. Unlike isoform 1, isoform 2, T1-TrpRS and T2-TrpRS, exhibit vasostatic activity. WARS Protein, Human (sf9, His) is the recombinant human-derived WARS protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of WARS Protein, Human (sf9, His) is 470 a.a., with molecular weight of ~55 kDa.

HY-P71375

	TPH2 Protein, Human (His) tryptophan 5-Hydroxylase 2; Neuronal tryptophan Hydroxylase; tryptophan 5-Monooxygenase 2; TPH2; NTPH	Human	E. coli
	TPH2 Protein, an isozyme of tryptophan hydroxylase, is a member of the pterin-dependent aromatic acid hydroxylase family. TPH2 is selectively expressed only in the serotonergic neurons of the raphe nuclei and is a rate-limiting enzyme in the brain serotonin synthesis pathway. TPH2 plays a more prominent role in the 5-HT synthesis in the brain. Moreover, it is a key factor in maintaining normal serotonin transfer in the central nervous system. TPH2 Protein, Human (His) is the recombinant human-derived TPH2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71099

	TrpB Protein, E.coli (His) tryptophan synthase beta chain; trpB	E.coli	E. coli
	The TrpB protein, especially its β subunit, plays a crucial role in the synthesis of L-tryptophan from indole and L-serine. This enzyme function involves converting precursor molecules into the essential amino acid L-tryptophan, thereby facilitating its biosynthetic pathway. TrpB Protein, E.coli (His) is the recombinant E. coli-derived TrpB protein, expressed by E. coli , with N-6*His labeled tag. The total length of TrpB Protein, E.coli (His) is 396 a.a., with molecular weight of 40-50 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-N0623S

*L-Tryptophan-d5*
L-Tryptophan-d₅ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S5

*L-Tryptophan-d8*
L-Tryptophan-d₈ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S9

*L-Tryptophan-d3*
L-Tryptophan-d₃ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S1

*L-Tryptophan-13C*
L-Tryptophan- ¹³C is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S7

*L-Tryptophan-15N*
L-Tryptophan- ¹⁵N is the ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S3

*L-Tryptophan-1-13C*
L-Tryptophan-1- ¹³C is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S2

*L-Tryptophan-13C11*
L-Tryptophan- ¹³C₁₁ is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S4

*L-Tryptophan-13C11,15N2*
L-Tryptophan- ¹³C₁₁, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S8

*L-Tryptophan-15N2*
L-Tryptophan- ¹⁵N₂ is the ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-N0623S6

*L-Tryptophan-15N2,d8*
L-Tryptophan- ¹⁵N₂,d₈ is the deuterium and ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-W012480S

*DL-Tryptophan-d3*
DL-Tryptophan-d₃ is the deuterium labeled DL-Tryptophan. DL-Tryptophan is an endogenous metabolite.

HY-W012480S1

*DL-Tryptophan-d8*
DL-Tryptophan-d₈ is the deuterium labeled DL-Tryptophan. DL-Tryptophan is an endogenous metabolite.

HY-142127S

*2-(α-D-Mannopyranosyl)-L-tryptophan-d4*
2-(α-D-Mannopyranosyl)-L-tryptophan-d₄ is the deuterium labeled 2-(α-D-Mannopyranosyl)-L-tryptophan[1].

HY-146628S

*5-Hydroxy-L-tryptophan-4,6,7-d3*
5-Hydroxy-L-tryptophan-4,6,7-d₃ is the deuterium labeled 5-Hydroxy-L-tryptophan-4,6,7[1].

HY-W012479S

H-D-Trp-OH-d5
H-D-Trp-OH-d₅ (D-Tryptophan-d₅) is the deuterium labeled H-D-Trp-OH. H-D-Trp-OH is a D-stereoisomer of tryptophan and occasionally found in naturally produced peptides such as the marine venom peptide.

HY-N0707S

(S)-Indoximod-d3
(S)-Indoximod-d₃ is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].

HY-N0623S10

L-Phenylalanine,Indole-15N
L-Phenylalanine,Indole- ¹⁵N is the ¹⁵N labeled L-Tryptophan[1]. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[2].

HY-113099S

Indolelactic acid-d5
Indolelactic acid-d₅ is the deuterium labeled Indolelactic acid. Indolelactic acid is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures.

HY-104026S1

L-Kynurenine-d4-1
L-Kynurenine-d₄-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-104026S

L-Kynurenine-d4
L-Kynurenine-d₄ is the deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist[1][2].

HY-104026S2

L-Kynurenine-d4-1 hydrochloride
L-Kynurenine-d₄-1 hydrochloride is the deuterium labeled L-Kynurenine (HY-104026). L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist .

HY-W008820S

Glutaric acid-d6 1 Publications Verification
Glutaric acid-d₆ is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-W008820S1

Glutaric acid-d4
Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-W008820S2

Glutaric acid-d2
Glutaric acid-d₂ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-104026S3

L-Kynurenine-13C4,15N-1
L-Kynurenine- ¹³C₄, ¹⁵N-1 is the ¹³C and ¹⁵N labled L-Kynurenine (HY-104026) . L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-100806S

Kynurenic acid-d5
Kynurenic acid-d₅ is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].

HY-100807S

Quinolinic acid-d3
Quinolinic acid-d₃ is the deuterium labeled Quinolinic acid. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].

HY-100807S1

Quinolinic acid-13C7
Quinolinic acid- ¹³C₇is the ¹³C labeledQuinolinic acid(HY-100807) . Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction .

HY-W718300

Indole-3-pyruvic acid-d5
Indole-3-pyruvic acid-d₅ is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety .

HY-12390S

Lofepramine-d3

Lofepramine-d₃ (Lopramine-d3) is the deuterium labeled Lofepramine. Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].

HY-113294S

3-Hydroxykynurenine-13C3,15N
3-Hydroxykynurenine- ¹³C₃, ¹⁵N (3-Hydroxy-DL-kynurenine- ¹³C₃, ¹⁵N)is the ¹³C and ¹⁵N labeled3-Hydroxykynurenine(HY-113294) . 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .

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HY-P80525

	14-3-3 eta Antibody (YA838) 14-3-3 protein eta; 1433F_HUMAN; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; Tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide; YWHA 1; YWHA1; Ywhah.	WB	Human, Mouse, Rat
	14-3-3 eta Antibody (YA838) is a non-conjugated and Mouse origined monoclonal antibody about 28 kDa, targeting to 14-3-3 eta (5F2). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P83004

	Tryptophan 5 Hydroxylase 1 Antibody (YA2749) TPH1; MGC119994; TPRH; TRPH; tryptophan 5-hydroxylase 1; tryptophan Hydroxylase	WB, IHC-P, IP	Human, Mouse, Rat
	Tryptophan 5 Hydroxylase 1 Antibody (YA2749) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2749), targeting Tryptophan 5 Hydroxylase 1, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). Tryptophan 5 Hydroxylase 1 Antibody (YA2749) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P81863

	Tryptophan tRNA Ligase Antibody (YA1608) Gamma2; hWRS; IFI53; IFP53; TrpRS; WARS; WRS	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Tryptophan tRNA Ligase Antibody (YA1608) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1608), targeting Tryptophan tRNA Ligase, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). Tryptophan tRNA Ligase Antibody (YA1608) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

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Cat. No.	Product Name		Classification

HY-23460

p-Ethynylphenylalanine 1 Publications Verification 4-Ethynyl-L-phenylalanine		Alkynes
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-23460A

p-Ethynylphenylalanine hydrochloride 1 Publications Verification 4-Ethynyl-L-phenylalanine hydrochloride		Alkynes
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-N0623

L-Tryptophan 4 Publications Verification tryptophan; tryptophane		Freeze-drying Protective Agents Solubilizing Agents
L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels .

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