Quinolinic acid-d₃

Name: Quinolinic acid-d 3
Brand: MedChemExpress
SKU: HY-100807S
Rating: 4.5 (1 reviews)

Cat. No.: HY-100807S Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Quinolinic acid-d₃ is the deuterium labeled Quinolinic acid. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction[1][2].

For research use only. We do not sell to patients.

Quinolinic acid-d<sub>3</sub> Chemical Structure

Quinolinic acid-d₃ Chemical Structure

CAS No. : 138946-42-6

Size	Price	Stock	Quantity
1 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1980	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2980	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Quinolinic acid-d₃:

Quinolinic acid In-stock
Quinolinic acid-¹³C₇ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NMDA Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

170.14

Formula

C₇H₂D₃NO₄

CAS No.

138946-42-6

Unlabeled CAS

89-00-9

Appearance

Solid

Color

White to off-white

SMILES

[2H]C1=C([2H])C([2H])=C(C(O)=O)C(C(O)=O)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (195.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 3.33 mg/mL (19.57 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8775 mL	29.3876 mL	58.7751 mL
5 mM	1.1755 mL	5.8775 mL	11.7550 mL
10 mM	0.5878 mL	2.9388 mL	5.8775 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (254 KB) HNMR (552 KB) RP-HPLC (800 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73. [Content Brief]

[3]. Jang S, et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	5.8775 mL	29.3876 mL	58.7751 mL	146.9378 mL
	5 mM	1.1755 mL	5.8775 mL	11.7550 mL	29.3876 mL
	10 mM	0.5878 mL	2.9388 mL	5.8775 mL	14.6938 mL
	15 mM	0.3918 mL	1.9592 mL	3.9183 mL	9.7959 mL
DMSO / DMSO	20 mM	0.2939 mL	1.4694 mL	2.9388 mL	7.3469 mL
	25 mM	0.2351 mL	1.1755 mL	2.3510 mL	5.8775 mL
	30 mM	0.1959 mL	0.9796 mL	1.9592 mL	4.8979 mL
	40 mM	0.1469 mL	0.7347 mL	1.4694 mL	3.6734 mL
	50 mM	0.1176 mL	0.5878 mL	1.1755 mL	2.9388 mL
	60 mM	0.0980 mL	0.4898 mL	0.9796 mL	2.4490 mL
	80 mM	0.0735 mL	0.3673 mL	0.7347 mL	1.8367 mL
	100 mM	0.0588 mL	0.2939 mL	0.5878 mL	1.4694 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.