2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase
  4. TPT-004

TPT-004 is a TPH inhibitor. TPT-004 has superior pharmacokinetic and pharmacodynamic properties. TPT-004 also has good efficacy in preclinical models of peripheral serotonin attenuation and colorectal tumor growth.

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TPT-004 Chemical Structure

TPT-004 Chemical Structure

CAS No. : 3032648-15-7

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Based on 1 publication(s) in Google Scholar

TPT-004 Related Antibodies

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Description

TPT-004 is a TPH inhibitor. TPT-004 has superior pharmacokinetic and pharmacodynamic properties. TPT-004 also has good efficacy in preclinical models of peripheral serotonin attenuation and colorectal tumor growth[1].

Molecular Weight

400.45

Formula

C18H20N6O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCN1C2=C(C(NC1=O)=O)N(C(CC3=CN4C=C(SC4=N3)C)=N2)CC5COC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4972 mL 12.4860 mL 24.9719 mL
5 mM 0.4994 mL 2.4972 mL 4.9944 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4972 mL 12.4860 mL 24.9719 mL 62.4298 mL
5 mM 0.4994 mL 2.4972 mL 4.9944 mL 12.4860 mL
10 mM 0.2497 mL 1.2486 mL 2.4972 mL 6.2430 mL
15 mM 0.1665 mL 0.8324 mL 1.6648 mL 4.1620 mL
20 mM 0.1249 mL 0.6243 mL 1.2486 mL 3.1215 mL
25 mM 0.0999 mL 0.4994 mL 0.9989 mL 2.4972 mL
30 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0810 mL
40 mM 0.0624 mL 0.3121 mL 0.6243 mL 1.5607 mL
50 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2486 mL
60 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0405 mL
80 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7804 mL
100 mM 0.0250 mL 0.1249 mL 0.2497 mL 0.6243 mL
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TPT-004 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPT-0043032648-15-7TPT004TPT 004Tryptophan HydroxylaseTryptophan hydroxylasepharmacokineticpharmacodynamicsperipheral serotonin attenuationcolorectal tumor growthInhibitorinhibitorinhibit

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