2. Anti-infection Stem Cell/Wnt JAK/STAT Signaling
  3. Bacterial STAT
  4. Golotimod hydrochloride

Golotimod hydrochloride  (Synonyms: SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride)

Cat. No.: HY-14743B Purity: 99.79%
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Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).

For research use only. We do not sell to patients.

Golotimod hydrochloride Chemical Structure

Golotimod hydrochloride Chemical Structure

CAS No. : 1029401-59-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 285 In-stock
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10 mM * 1 mL in Water USD 285 In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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Golotimod hydrochloride Related Antibodies

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Description

Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].

IC50 & Target[2]

STAT3

 

In Vivo

Golotimod (SCV-07) hydrochloride (oral gavage or subcutaneous injection, 100 μg/kg, 5 days) reduces experimental recurrent genital HSV-2 disease by oral administration, more importantly, oral SCV07 after fasting shows a greater reduction in incidence and severity than SCV-07 without fasting in female hartley guinea pigs[1].
Golotimod (SCV-07) hydrochloride (subcutaneous injection, once or twice a day from days 1 to 20, 100 μg/kg) can reduce the severity and duration of acute and split radiation-induced oral mucositis (OM) and short the duration of ulcerative OM in male LVG golden Syrian Hamsters[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Hartley guinea pigs (250-300 g) infected HSV-2[1]
Dosage: 100 μg/kg
Administration: Oral gavage or subcutaneous injection; 5 days
Result: Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07.
Animal Model: Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis[3]
Dosage: 10, 100 μg/kg or 1 mg/kg
Administration: Subcutaneous injection; once or twice a day from days 1 to 20
Result: Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg.
Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg.
Clinical Trial
Molecular Weight

369.80

Formula

C16H20ClN3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC[C@@](N)(C(O)=O)[H])NC([H])(C(O)=O)CC1=CNC2=C1C=CC=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 150 mg/mL (405.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7042 mL 13.5208 mL 27.0416 mL
5 mM 0.5408 mL 2.7042 mL 5.4083 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 20 mg/mL (54.08 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7042 mL 13.5208 mL 27.0416 mL 67.6041 mL
5 mM 0.5408 mL 2.7042 mL 5.4083 mL 13.5208 mL
10 mM 0.2704 mL 1.3521 mL 2.7042 mL 6.7604 mL
15 mM 0.1803 mL 0.9014 mL 1.8028 mL 4.5069 mL
20 mM 0.1352 mL 0.6760 mL 1.3521 mL 3.3802 mL
25 mM 0.1082 mL 0.5408 mL 1.0817 mL 2.7042 mL
30 mM 0.0901 mL 0.4507 mL 0.9014 mL 2.2535 mL
40 mM 0.0676 mL 0.3380 mL 0.6760 mL 1.6901 mL
50 mM 0.0541 mL 0.2704 mL 0.5408 mL 1.3521 mL
60 mM 0.0451 mL 0.2253 mL 0.4507 mL 1.1267 mL
80 mM 0.0338 mL 0.1690 mL 0.3380 mL 0.8451 mL
100 mM 0.0270 mL 0.1352 mL 0.2704 mL 0.6760 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Golotimod hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Golotimod1029401-59-9SCV 07Gamma-D-glutamyl-L-tryptophanSCV07SCV-07BacterialSTATimmunomodulating peptideantimicrobialmacrophageoral mucositisHSV-2Inhibitorinhibitorinhibit

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