3-Hydroxykynurenine-¹³C₃,¹⁵N  (Synonyms: 3-Hydroxy-DL-kynurenine-¹³C₃,¹⁵N)

3-Hydroxykynurenine-¹³C₃,¹⁵N (3-Hydroxy-DL-kynurenine-¹³C₃,¹⁵N)is the ¹³C and ¹⁵N labeled3-Hydroxykynurenine(HY-113294)^[1]. 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

228.18

C₇¹³C₃H₁₂N¹⁵NO₄

2267306-16-9

484-78-6

Solid

Yellow to brown

O=C(C(C=CC=C1O)=C1N)[13CH2][13CH]([15NH2])[13C](O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]