Shizukaol B 

Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression^[1].

Shizukaol B (25 μM; 0-60 min) inhibits LPS-mediated (1 μg/mL; 0-60 min) c-Jun N-terminal kinase 1/2 (JNK) activation, without affecting ERK1/2 or p38 phosphorylation^[1].
Shizukaol B (12.5-50 μM; 4 h) inhibits LPS-induced (1 μg/mL; 24 h) NO production and expression of iNOS and COX-2 in BV2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

732.77

C₄₀H₄₄O₁₃

142279-40-1

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pan LL, et al. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017 Apr;88:878-884.  [Content Brief]