2. Neuronal Signaling Anti-infection
  3. CaMK Fungal Antibiotic
  4. Sordarin sodium

Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae).

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Sordarin sodium Chemical Structure

Sordarin sodium Chemical Structure

CAS No. : 463356-00-5

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Sordarin sodium Related Antibodies

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Description

Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae)[1][2].

IC50 & Target

IC50: eEF2; fungal[1]
Molecular Weight

514.58

Formula

C27H39NaO8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@]([C@]12C=O)(C(C(C)C)=C[C@H]3C1)[C@@]3(C[C@@]4([H])[C@@]2([H])CC[C@H]4C)CO[C@H](O[C@@H]5C)[C@H]([C@@H]([C@@H]5OC)O)O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

COA (262 KB)

Handling Instructions (2659 KB)
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Sordarin sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sordarin463356-00-5CaMKFungalAntibioticCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesC.?albicansC.?glabrataC.?neoformansCandida parapsilosisCandida lusitaniaeeEF2antifungalInhibitorinhibitorinhibit

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