Sucrosofate potassium (Synonyms: Sucrose octasulfate potassium)

Cat. No.: HY-141436 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Sucrosofate (Sucrose octasulfate) potassium is a sucrose acid that can be used to prepare liposomes to deliver Irinotecan (HY-16562). Irinotecan is an inhibitor of topoisomerase Topo I and is commonly used in colon and rectal cancer research. Sucrosofate nanoliposome preparation loaded with Irinotecan, also known as PEP02 or MM-398.

For research use only. We do not sell to patients.

Sucrosofate potassium Chemical Structure

CAS No. : 73264-44-5

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
25 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 48	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Purity & Documentation
References
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Description

Molecular Weight

1287.52

Formula

C₁₂H₁₄K₈O₃₅S₈

CAS No.

73264-44-5

Appearance

Solid

Color

White to off-white

SMILES

O=S(OC[C@@]1([C@H]([C@@H]([C@H](O1)COS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)COS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)(O[K])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (135.92 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7767 mL	3.8834 mL	7.7669 mL
5 mM	0.1553 mL	0.7767 mL	1.5534 mL
10 mM	0.0777 mL	0.3883 mL	0.7767 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (290 KB) SDS (393 KB)

COA (275 KB) HNMR (302 KB)

Handling Instructions (2659 KB)

References

[1]. Ko A H, Tempero M A, Shan Y S, et al. A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer[J]. British journal of cancer, 2013, 109(4): 920-925.

[2]. Klinz S G, Zheng J, De Souza R, et al. Abstract C293: Irinotecan sucrosofate liposome injection, MM-398, demonstrates superior activity and control of hypoxia as measured through longitudinal imaging using [18F] FAZA PET compared to free irinotecan in a colon adenocarcinoma xenograft model[J]. Molecular Cancer Therapeutics, 2013, 12(11_Supplement): C293-C293.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.7767 mL	3.8834 mL	7.7669 mL	19.4172 mL
	5 mM	0.1553 mL	0.7767 mL	1.5534 mL	3.8834 mL
	10 mM	0.0777 mL	0.3883 mL	0.7767 mL	1.9417 mL
	15 mM	0.0518 mL	0.2589 mL	0.5178 mL	1.2945 mL
	20 mM	0.0388 mL	0.1942 mL	0.3883 mL	0.9709 mL
	25 mM	0.0311 mL	0.1553 mL	0.3107 mL	0.7767 mL
	30 mM	0.0259 mL	0.1294 mL	0.2589 mL	0.6472 mL
	40 mM	0.0194 mL	0.0971 mL	0.1942 mL	0.4854 mL
	50 mM	0.0155 mL	0.0777 mL	0.1553 mL	0.3883 mL
	60 mM	0.0129 mL	0.0647 mL	0.1294 mL	0.3236 mL
	80 mM	0.0097 mL	0.0485 mL	0.0971 mL	0.2427 mL
	100 mM	0.0078 mL	0.0388 mL	0.0777 mL	0.1942 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sucrosofate potassium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sucrosofate73264-44-5Sucrose octasulfateBiochemical Assay ReagentsInhibitorinhibitorinhibit

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