2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. [Sar9,Met(O2)11]-Substance P

[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.

For research use only. We do not sell to patients.

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[Sar9,Met(O2)11]-Substance P Chemical Structure

[Sar9,Met(O2)11]-Substance P Chemical Structure

CAS No. : 110880-55-2

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1 mg USD 96 In-stock
5 mg USD 348 In-stock
10 mg USD 624 In-stock
25 mg USD 1320 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of [Sar9,Met(O2)11]-Substance P:

[Sar9,Met(O2)11]-Substance P Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.

IC50 & Target

NK1 receptor[1]
In Vitro

[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Sar9,Met(O2)11]-Substance P Related Antibodies
Molecular Weight

1393.66

Formula

C64H100N18O15S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-{Met[O2]}-NH2
Sequence Shortening

RPKPQQFF-{Sar}-L-{Met[O2]}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (71.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7175 mL 3.5877 mL 7.1754 mL
5 mM 0.1435 mL 0.7175 mL 1.4351 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (71.75 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
Kinase Assay
[1]

Rats initially receive an i.c.v. injection of artificial cerebrospinal fluid (aCSF; 1 μl) followed 60 min later by a single dose of either [Sar9,Met(O2)11]-Substance P (10 pmol (n=9), 25 pmol (n=9), 65 pmol (n=8) or 100 pmol (n=8)) or septide (10 pmol (n=12), 25 pmol (n=9), 65 pmol (n=6) or 100 pmol (n=6)) to construct a complete dose-response curve. Each rat is selected randomly and injected with only one of the two agonists for the remainder of the protocol. Increasing doses of [Sar9,Met(O2)11]-Substance P or septide are given at 24 h intervals on day 1 (10 pmol), day 2 (25 pmol), day 3 (65 pmol) and day 4 (100 pmol). Control rats (n=18) receive only the vehicle (aCSF) each day of experiment. Peptides are administered in a volume of 1 μL of vehicle followed by 5 μL flush volume of aCSF which corresponds to the void volume of the catheter. Each dose is calculated per rat in 1 μL solution[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7175 mL 3.5877 mL 7.1754 mL 17.9384 mL
5 mM 0.1435 mL 0.7175 mL 1.4351 mL 3.5877 mL
10 mM 0.0718 mL 0.3588 mL 0.7175 mL 1.7938 mL
15 mM 0.0478 mL 0.2392 mL 0.4784 mL 1.1959 mL
20 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8969 mL
25 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7175 mL
30 mM 0.0239 mL 0.1196 mL 0.2392 mL 0.5979 mL
40 mM 0.0179 mL 0.0897 mL 0.1794 mL 0.4485 mL
50 mM 0.0144 mL 0.0718 mL 0.1435 mL 0.3588 mL
60 mM 0.0120 mL 0.0598 mL 0.1196 mL 0.2990 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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[Sar9,Met(O2)11]-Substance P Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Sar9,Met(O2)11]-Substance P110880-55-2Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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